LOCUS NP_078946 350 aa linear PRI 18-MAR-2023
DEFINITION histone-lysine N-methyltransferase SUV39H2 isoform 2 [Homo
sapiens].
ACCESSION NP_078946
VERSION NP_078946.1
DBSOURCE REFSEQ: accession NM_024670.4
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 350)
AUTHORS Yang J, Xu P, Chen Z, Zhang X, Xia Y, Fang L, Xie L, Li B and Xu Z.
TITLE N6-methyadenosine modified SUV39H2 regulates homologous
recombination through epigenetic repression of DUSP6 in gastric
cancer
JOURNAL Cancer Lett 558, 216092 (2023)
PUBMED 36806557
REMARK GeneRIF: N6-methyadenosine modified SUV39H2 regulates homologous
recombination through epigenetic repression of DUSP6 in gastric
cancer.
REFERENCE 2 (residues 1 to 350)
AUTHORS Luu J, Kallestad L, Hoang T, Lewandowski D, Dong Z, Blackshaw S and
Palczewski K.
TITLE Epigenetic hallmarks of age-related macular degeneration are
recapitulated in a photosensitive mouse model
JOURNAL Hum Mol Genet 29 (15), 2611-2624 (2020)
PUBMED 32691052
REMARK GeneRIF: Epigenetic hallmarks of age-related macular degeneration
are recapitulated in a photosensitive mouse model.
REFERENCE 3 (residues 1 to 350)
AUTHORS Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
TITLE Extensive disruption of protein interactions by genetic variants
across the allele frequency spectrum in human populations
JOURNAL Nat Commun 10 (1), 4141 (2019)
PUBMED 31515488
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 350)
AUTHORS Chao C, You J, Li H, Xue H and Tan X.
TITLE Elevated SUV39H2 attributes to the progression of nasopharyngeal
carcinoma via regulation of NRIP1
JOURNAL Biochem Biophys Res Commun 510 (2), 290-295 (2019)
PUBMED 30709585
REMARK GeneRIF: SUV39H2 elevation contributes to the progression of
nasopharyngeal carcinoma via regulation of NRIP1
REFERENCE 5 (residues 1 to 350)
AUTHORS Piao L, Yuan X, Zhuang M, Qiu X, Xu X, Kong R and Liu Z.
TITLE Histone methyltransferase SUV39H2 serves oncogenic roles in
osteosarcoma
JOURNAL Oncol Rep 41 (1), 325-332 (2019)
PUBMED 30542727
REMARK GeneRIF: Knockdown of SUV39H2 expression by specific siRNAs in
human osteosarcoma cell lines markedly suppressed cancer cell
growth and caused an increase in the population of cells in G1
phase and induced apoptosis. Overexpression of SUV39H2 promoted
cell proliferation, which indicated that SUV39H2 may possess
oncogenic activity in human osteosarcoma.
REFERENCE 6 (residues 1 to 350)
AUTHORS Frontelo P, Leader JE, Yoo N, Potocki AC, Crawford M, Kulik M and
Lechleider RJ.
TITLE Suv39h histone methyltransferases interact with Smads and cooperate
in BMP-induced repression
JOURNAL Oncogene 23 (30), 5242-5251 (2004)
PUBMED 15107829
REFERENCE 7 (residues 1 to 350)
AUTHORS Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L,
Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE,
Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles
J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD,
Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H,
Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J,
Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee
CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner
L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S,
Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E,
Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C,
Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK,
Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird
G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE,
McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson
T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan
S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou
T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore
N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J,
Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead
SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK,
Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T,
Doucette-Stamm L, Beck S, Smith DR and Rogers J.
TITLE The DNA sequence and comparative analysis of human chromosome 10
JOURNAL Nature 429 (6990), 375-381 (2004)
PUBMED 15164054
REFERENCE 8 (residues 1 to 350)
AUTHORS Ait-Si-Ali S, Guasconi V, Fritsch L, Yahi H, Sekhri R, Naguibneva
I, Robin P, Cabon F, Polesskaya A and Harel-Bellan A.
TITLE A Suv39h-dependent mechanism for silencing S-phase genes in
differentiating but not in cycling cells
JOURNAL EMBO J 23 (3), 605-615 (2004)
PUBMED 14765126
REFERENCE 9 (residues 1 to 350)
AUTHORS O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible
G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei
MG, Denny P, Brown SD, Schweizer D and Jenuwein T.
TITLE Isolation and characterization of Suv39h2, a second histone H3
methyltransferase gene that displays testis-specific expression
JOURNAL Mol Cell Biol 20 (24), 9423-9433 (2000)
PUBMED 11094092
REFERENCE 10 (residues 1 to 350)
AUTHORS Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M,
Opravil S, Mechtler K, Ponting CP, Allis CD and Jenuwein T.
TITLE Regulation of chromatin structure by site-specific histone H3
methyltransferases
JOURNAL Nature 406 (6796), 593-599 (2000)
PUBMED 10949293
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC069544.9 and BC007754.2.
Transcript Variant: This variant (3) contains an alternate 5'
terminal exon, and is missing the subsequent exon compared to
variant 1. This results in translation initiation from an in-frame,
downstream AUG, and a shorter isoform (2) compared to isoform 1.
Variants 2 and 3 encode the same isoform.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC007754.2, SRR18074967.3096146.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA2146236, SAMEA2162946
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..350
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="10"
/map="10p13"
Protein 1..350
/product="histone-lysine N-methyltransferase SUV39H2
isoform 2"
/EC_number="2.1.1.355"
/note="histone-lysine N-methyltransferase SUV39H2;
H3-K9-HMTase 2; su(var)3-9 homolog 2; lysine
N-methyltransferase 1B; histone H3-K9 methyltransferase 2;
suppressor of variegation 3-9 homolog 2; histone
methyltransferase SUV39H2"
/calculated_mol_wt=39816
Region <1..35
/region_name="CD_CSD"
/note="CHROMO (CHRromatin Organization Modifier) domains
and chromo shadow domains; cl28914"
/db_xref="CDD:452897"
Region 107..349
/region_name="SET_SUV39H2"
/note="SET domain (including pre-SET and post-SET domains)
found in suppressor of variegation 3-9 homolog 2 (SUV39H2)
and similar proteins; cd10532"
/db_xref="CDD:380930"
Site order(201..203,243..244,267..271,312,337..340,349)
/site_type="other"
/note="putative SAM binding site"
/db_xref="CDD:380930"
Site order(201..203,220,227,230..231,233,242..247,250,256,
267..271,279,281,294,310,312,336..340)
/site_type="active"
/note="putative active site [active]"
/db_xref="CDD:380930"
Site order(245..247,256,279,294,312)
/site_type="other"
/note="putative polypeptide substrate binding site
[polypeptide binding]"
/db_xref="CDD:380930"
Site order(273,338,340,345)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:380930"
CDS 1..350
/gene="SUV39H2"
/gene_synonym="KMT1B"
/coded_by="NM_024670.4:266..1318"
/note="isoform 2 is encoded by transcript variant 3"
/db_xref="CCDS:CCDS7104.1"
/db_xref="GeneID:79723"
/db_xref="HGNC:HGNC:17287"
/db_xref="MIM:606503"
ORIGIN
1 meyylvkwkg wpdstntwep lqnlkcplll qqfsndkhny lsqvkkgkai tpkdnnktlk
61 paiaeyivkk akqrialqrw qdelnrrknh kgmifventv dlegppsdfy yineykpapg
121 islvneatfg csctdcffqk ccpaeagvll aynknqqiki ppgtpiyecn srcqcgpdcp
181 nrivqkgtqy slcifrtsng rgwgvktlvk ikrmsfvmey vgevitseea errgqfydnk
241 gitylfdldy esdeftvdaa rygnvshfvn hscdpnlqvf nvfidnldtr lprialfstr
301 tinageeltf dyqmkgsgdi ssdsidhspa kkrvrtvckc gavtcrgyln
//
