LOCUS NP_081694 720 aa linear ROD 13-JUN-2023
DEFINITION mitogen-activated protein kinase 6 [Mus musculus].
ACCESSION NP_081694 XP_486234
VERSION NP_081694.1
DBSOURCE REFSEQ: accession NM_027418.2
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 720)
AUTHORS Loza-Valdes A, El-Merahbi R, Kassouf T, Demczuk A, Reuter S, Viera
JT, Karwen T, Noh M, Loffler MC, Romero-Becerra R, Torres JL,
Marcos M, Sabio G, Wojda U and Sumara G.
TITLE Targeting ERK3/MK5 complex for treatment of obesity and diabetes
JOURNAL Biochem Biophys Res Commun 612, 119-125 (2022)
PUBMED 35523049
REFERENCE 2 (residues 1 to 720)
AUTHORS Yao T, Zha D, Hu C and Wu X.
TITLE Circ_0000285 promotes podocyte injury through sponging miR-654-3p
and activating MAPK6 in diabetic nephropathy
JOURNAL Gene 747, 144661 (2020)
PUBMED 32275999
REMARK GeneRIF: circ_0000285 promoted podocyte injury via sponging
miR-654-3p and activating MAPK6 in diabetic nephropathy.
REFERENCE 3 (residues 1 to 720)
AUTHORS El-Merahbi R, Viera JT, Valdes AL, Kolczynska K, Reuter S, Loffler
MC, Erk M, Ade CP, Karwen T, Mayer AE, Eilers M and Sumara G.
TITLE The adrenergic-induced ERK3 pathway drives lipolysis and suppresses
energy dissipation
JOURNAL Genes Dev 34 (7-8), 495-510 (2020)
PUBMED 32139423
REFERENCE 4 (residues 1 to 720)
AUTHORS Soulez M, Saba-El-Leil MK, Turgeon B, Mathien S, Coulombe P,
Klinger S, Rousseau J, Levesque K and Meloche S.
TITLE Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3
in Perinatal Survival and Postnatal Growth Using New Genetically
Engineered Mouse Models
JOURNAL Mol Cell Biol 39 (6), e00527-18 (2019)
PUBMED 30642949
REMARK Publication Status: Online-Only
REFERENCE 5 (residues 1 to 720)
AUTHORS Sirois J, Daudelin JF, Boulet S, Marquis M, Meloche S and Labrecque
N.
TITLE The atypical MAPK ERK3 controls positive selection of thymocytes
JOURNAL Immunology 145 (1), 161-169 (2015)
PUBMED 25521218
REFERENCE 6 (residues 1 to 720)
AUTHORS Coulombe P, Rodier G, Pelletier S, Pellerin J and Meloche S.
TITLE Rapid turnover of extracellular signal-regulated kinase 3 by the
ubiquitin-proteasome pathway defines a novel paradigm of
mitogen-activated protein kinase regulation during cellular
differentiation
JOURNAL Mol Cell Biol 23 (13), 4542-4558 (2003)
PUBMED 12808096
REMARK GeneRIF: ERK3 biological activity is regulated by its cellular
abundance through the control of protein stability
REFERENCE 7 (residues 1 to 720)
AUTHORS Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
Babbitt PC and Ferrin TE.
TITLE BayGenomics: a resource of insertional mutations in mouse embryonic
stem cells
JOURNAL Nucleic Acids Res 31 (1), 278-281 (2003)
PUBMED 12520002
REFERENCE 8 (residues 1 to 720)
AUTHORS Turgeon B, Lang BF and Meloche S.
TITLE The protein kinase ERK3 is encoded by a single functional gene:
genomic analysis of the ERK3 gene family
JOURNAL Genomics 80 (6), 673-680 (2002)
PUBMED 12504858
REFERENCE 9 (residues 1 to 720)
AUTHORS Turgeon B, Saba-El-Leil MK and Meloche S.
TITLE Cloning and characterization of mouse
extracellular-signal-regulated protein kinase 3 as a unique gene
product of 100 kDa
JOURNAL Biochem J 346 Pt 1 (Pt 1), 169-175 (2000)
PUBMED 10657254
REFERENCE 10 (residues 1 to 720)
AUTHORS Ershler M, Nagorskaya TV, Visser JW and Belyavsky AV.
TITLE Novel CDC2-related protein kinases produced in murine hematopoietic
stem cells
JOURNAL Gene 124 (2), 305-306 (1993)
PUBMED 8444355
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BY737145.1, BC100385.1, BC048779.1, AK051508.1 and AC115880.11.
On Oct 1, 2005 this sequence version replaced XP_486234.1.
Transcript Variant: This variant (2) represents the longer
transcript. Variants 1 and 2 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR11927937.3082602.1,
SRR7974084.14550.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849381, SAMN01164137
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..720
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="9"
/map="9 42.3 cM"
Protein 1..720
/product="mitogen-activated protein kinase 6"
/EC_number="2.7.11.24"
/note="MAP kinase 6; extracellular signal-regulated kinase
3; mitogen activated protein kinase 4; protein kinase,
mitogen activated kinase 4; Erk-3 related"
/calculated_mol_wt=82069
Region 14..355
/region_name="STKc_MAPK4_6"
/note="Catalytic domain of the Serine/Threonine Kinases,
Mitogen-Activated Protein Kinases 4 (also called ERK4) and
6 (also called ERK3); cd07854"
/db_xref="CDD:143359"
Site order(26..29,31..32,34,47,49,64,78,108..111,114,116..117,
152,154,156..157,159,170..171,174,189,191..194,196,234)
/site_type="active"
/db_xref="CDD:143359"
Site order(26..29,31..32,34,47,49,78,108..111,114,117,154,
156..157,159,170..171)
/site_type="other"
/note="ATP binding site [chemical binding]"
/db_xref="CDD:143359"
Site order(64,116,152,154,174,189,191..194,196,234)
/site_type="other"
/note="polypeptide substrate binding site [polypeptide
binding]"
/db_xref="CDD:143359"
Site order(75,112..113,118,128,131,138,160..163,165,319,321,
324)
/site_type="other"
/note="KIM docking site [polypeptide binding]"
/db_xref="CDD:143359"
Site 170..196
/site_type="other"
/note="activation loop (A-loop)"
/db_xref="CDD:143359"
Region 189..191
/region_name="SEG motif"
/note="propagated from UniProtKB/Swiss-Prot (Q61532.3)"
Site 189
/site_type="phosphorylation"
/note="Phosphoserine, by PAK1, PAK2 and PAK3.
/evidence=ECO:0000305|PubMed:18720373; propagated from
UniProtKB/Swiss-Prot (Q61532.3)"
Region 332..337
/region_name="FRIEDE motif"
/note="propagated from UniProtKB/Swiss-Prot (Q61532.3)"
Site 386
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q16659; propagated from
UniProtKB/Swiss-Prot (Q61532.3)"
Site 554
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q16659; propagated from
UniProtKB/Swiss-Prot (Q61532.3)"
Site 556
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q16659; propagated from
UniProtKB/Swiss-Prot (Q61532.3)"
Region 638..657
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q61532.3)"
Site 683
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q16659; propagated from
UniProtKB/Swiss-Prot (Q61532.3)"
Region 700..720
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q61532.3)"
CDS 1..720
/gene="Mapk6"
/gene_synonym="2610021I23Rik; D130053K17Rik; Erk3; Mapk4;
Mapk63; Prkm4; Prkm6"
/coded_by="NM_027418.2:777..2939"
/db_xref="CCDS:CCDS23342.1"
/db_xref="GeneID:50772"
/db_xref="MGI:MGI:1354946"
ORIGIN
1 maekfeslmn ihgfdlgsry mdlkplgcgg nglvfsavdn dcdkrvaikk ivltdpqsvk
61 halreikiir rldhdnivkv feilgpsgsq ltddvgslte lnsvyivqey metdlanvle
121 qgplleehar lfmyqllrgl kyihsanvlh rdlkpanlfi ntedlvlkig dfglarimdp
181 hyshkghlse glvtkwyrsp rlllspnnyt kaidmwaagc ifaemltgkt lfagaheleq
241 mqlildsipv vheedrqell svipvyirnd mtephrpltq llpgisreal dfleqiltfs
301 pmdrltaeea lshpymsiys fptdepissh pfhiedevdd illmdethsh iynweryhdc
361 qfsehdwpih nnfdidevql dpralsdvtd eeevqvdprk yldgdrekyl edpafdtsys
421 aepcwqypdh henkycdlec shtcnyktrs spyldnlvwr esevnhyyep kliidlsnwk
481 eqskeksdkr gkskcerngl vkaqialeea sqqlaererg qgfdfdsfia gtiqlsaqhq
541 sadvvdklnd lnssvsqlel kslisksvsr ekqekgranl aqlgalyqss wdsqfvsgge
601 ecflisqfcc evrkdehaek entytsyldk ffsrkedsem letepveegk rgergreagl
661 lsgggeflls kqlesigtpq fhspvgsplk siqatltpsa mksspqiphk tyssilkhln
//
