LOCUS NP_174849 2254 aa linear PLN 14-FEB-2019
DEFINITION acetyl-CoA carboxylase 1 [Arabidopsis thaliana].
ACCESSION NP_174849
VERSION NP_174849.2
DBLINK BioProject: PRJNA116
BioSample: SAMN03081427
DBSOURCE REFSEQ: accession NM_103313.4
KEYWORDS RefSeq.
SOURCE Arabidopsis thaliana (thale cress)
ORGANISM Arabidopsis thaliana
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
Camelineae; Arabidopsis.
REFERENCE 1 (residues 1 to 2254)
AUTHORS Theologis,A., Ecker,J.R., Palm,C.J., Federspiel,N.A., Kaul,S.,
White,O., Alonso,J., Altafi,H., Araujo,R., Bowman,C.L.,
Brooks,S.Y., Buehler,E., Chan,A., Chao,Q., Chen,H., Cheuk,R.F.,
Chin,C.W., Chung,M.K., Conn,L., Conway,A.B., Conway,A.R.,
Creasy,T.H., Dewar,K., Dunn,P., Etgu,P., Feldblyum,T.V., Feng,J.,
Fong,B., Fujii,C.Y., Gill,J.E., Goldsmith,A.D., Haas,B.,
Hansen,N.F., Hughes,B., Huizar,L., Hunter,J.L., Jenkins,J.,
Johnson-Hopson,C., Khan,S., Khaykin,E., Kim,C.J., Koo,H.L.,
Kremenetskaia,I., Kurtz,D.B., Kwan,A., Lam,B., Langin-Hooper,S.,
Lee,A., Lee,J.M., Lenz,C.A., Li,J.H., Li,Y., Lin,X., Liu,S.X.,
Liu,Z.A., Luros,J.S., Maiti,R., Marziali,A., Militscher,J.,
Miranda,M., Nguyen,M., Nierman,W.C., Osborne,B.I., Pai,G.,
Peterson,J., Pham,P.K., Rizzo,M., Rooney,T., Rowley,D., Sakano,H.,
Salzberg,S.L., Schwartz,J.R., Shinn,P., Southwick,A.M., Sun,H.,
Tallon,L.J., Tambunga,G., Toriumi,M.J., Town,C.D., Utterback,T.,
Van Aken,S., Vaysberg,M., Vysotskaia,V.S., Walker,M., Wu,D., Yu,G.,
Fraser,C.M., Venter,J.C. and Davis,R.W.
TITLE Sequence and analysis of chromosome 1 of the plant Arabidopsis
thaliana
JOURNAL Nature 408 (6814), 816-820 (2000)
PUBMED 11130712
REFERENCE 2 (residues 1 to 2254)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (14-FEB-2019) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 3 (residues 1 to 2254)
AUTHORS Krishnakumar,V., Cheng,C.-Y., Chan,A.P., Schobel,S., Kim,M.,
Ferlanti,E.S., Belyaeva,I., Rosen,B.D., Micklem,G., Miller,J.R.,
Vaughn,M. and Town,C.D.
TITLE Direct Submission
JOURNAL Submitted (18-JUL-2017) Plant Genomics, J. Craig Venter Institute,
9704 Medical Center Dr, Rockville, MD 20850, USA
REMARK Protein update by submitter
REFERENCE 4 (residues 1 to 2254)
AUTHORS Krishnakumar,V., Cheng,C.-Y., Chan,A.P., Schobel,S., Kim,M.,
Ferlanti,E.S., Belyaeva,I., Rosen,B.D., Micklem,G., Miller,J.R.,
Vaughn,M. and Town,C.D.
TITLE Direct Submission
JOURNAL Submitted (17-MAY-2016) Plant Genomics, J. Craig Venter Institute,
9704 Medical Center Dr, Rockville, MD 20850, USA
REMARK Protein update by submitter
REFERENCE 5 (residues 1 to 2254)
AUTHORS Swarbreck,D., Lamesch,P., Wilks,C. and Huala,E.
CONSRTM TAIR
TITLE Direct Submission
JOURNAL Submitted (18-FEB-2011) Department of Plant Biology, Carnegie
Institution, 260 Panama Street, Stanford, CA, USA
COMMENT REVIEWED REFSEQ: This record has been curated by TAIR and Araport.
The reference sequence is identical to AEE31849.
On Nov 3, 2005 this sequence version replaced NP_174849.1.
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..2254
/organism="Arabidopsis thaliana"
/db_xref="taxon:3702"
/chromosome="1"
/ecotype="Columbia"
Protein 1..2254
/product="acetyl-CoA carboxylase 1"
/calculated_mol_wt=251252
Region 37..156
/region_name="CPSase_L_chain"
/note="Carbamoyl-phosphate synthase L chain, N-terminal
domain; pfam00289"
/db_xref="CDD:278706"
Region 40..545
/region_name="AccC"
/note="Biotin carboxylase [Lipid transport and
metabolism]; COG0439"
/db_xref="CDD:223516"
Region 161..385
/region_name="ATP-grasp_4"
/note="ATP-grasp domain; cl17255"
/db_xref="CDD:302634"
Region 432..539
/region_name="Biotin_carb_C"
/note="Biotin carboxylase C-terminal domain; pfam02785"
/db_xref="CDD:280880"
Region 601..741
/region_name="AccB"
/note="Biotin carboxyl carrier protein [Coenzyme transport
and metabolism, Lipid transport and metabolism]; COG0511"
/db_xref="CDD:223585"
Region 679..741
/region_name="biotinyl_domain"
/note="The biotinyl-domain or biotin carboxyl carrier
protein (BCCP) domain is present in all biotin-dependent
enzymes, such as acetyl-CoA carboxylase, pyruvate
carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA
carboxylase, geranyl-CoA carboxylase; cd06850"
/db_xref="CDD:133459"
Site order(701,710..712,719)
/site_type="other"
/note="carboxyltransferase (CT) interaction site"
/db_xref="CDD:133459"
Site 711
/site_type="other"
/note="biotinylation site [posttranslational
modification]"
/db_xref="CDD:133459"
Region 744..1485
/region_name="ACC_central"
/note="Acetyl-CoA carboxylase, central region; pfam08326"
/db_xref="CDD:285519"
Region 1587..2139
/region_name="Carboxyl_trans"
/note="Carboxyl transferase domain; pfam01039"
/db_xref="CDD:279390"
CDS 1..2254
/gene="ACC1"
/locus_tag="AT1G36160"
/gene_synonym="acetyl-CoA carboxylase 1; AT-ACC1; EMB22;
EMBRYO DEFECTIVE 22; GK; GLOSSYHEAD 1; GSD1; GURKE; PAS3;
PASTICCINO 3; SENSITIVE TO FREEZING 3; SFR3"
/coded_by="NM_103313.4:393..7157"
/inference="Similar to RNA sequence,
EST:INSD:AV560673.1,INSD:EL325050.1,INSD:ES111627.1,
INSD:EL237137.1,INSD:BP831799.1,INSD:EL094734.1,
INSD:ES431063.1,INSD:EH911055.1,INSD:AV548385.1,
INSD:CB258414.1,INSD:T14234.1,INSD:ES113437.1,
INSD:ES156460.1,INSD:EL260322.1,INSD:EL228298.1,
INSD:AU238199.1,INSD:ES108614.1,INSD:ES013443.1,
INSD:ES096240.1,INSD:EL317322.1,INSD:ES055992.1,
INSD:ES191297.1,INSD:EL229452.1,INSD:AV558165.1,
INSD:EL186533.1,INSD:EL226327.1,INSD:EH928086.1,
INSD:EL038787.1,INSD:BP837124.1,INSD:EL015337.1,
INSD:AI993440.1,INSD:ES062773.1,INSD:ES099197.1,
INSD:ES116085.1,INSD:EG441011.1,INSD:ES007183.1,
INSD:CB258412.1,INSD:EL242532.1,INSD:BE525265.1,
INSD:EH967927.1,INSD:EL183142.1,INSD:EH919553.1,
INSD:BP779528.1,INSD:EL122460.1,INSD:EL060683.1,
INSD:T88137.1,INSD:EL060659.1,INSD:N96095.1,
INSD:CD534716.1,INSD:EL261283.1,INSD:EL126402.1,
INSD:EL072998.1,INSD:ES132974.1,INSD:AU229343.1,
INSD:EH797260.1,INSD:EL111236.1,INSD:DR378198.1"
/inference="similar to RNA sequence,
mRNA:INSD:AK229488.1,INSD:D34630.2"
/note="acetyl-CoA carboxylase 1 (ACC1); FUNCTIONS IN:
acetyl-CoA carboxylase activity; INVOLVED IN: in 7
processes; LOCATED IN: plasma membrane; EXPRESSED IN: 26
plant structures; EXPRESSED DURING: 13 growth stages;
CONTAINS InterPro DOMAIN/s: Acetyl-coenzyme A
carboxyltransferase, N-terminal (InterPro:IPR011762),
Carboxyl transferase (InterPro:IPR000022), Biotin/lipoyl
attachment (InterPro:IPR000089), Carbamoyl phosphate
synthase, large subunit, N-terminal (InterPro:IPR005481),
PreATP-grasp-like fold (InterPro:IPR016185), ATP-grasp
fold (InterPro:IPR011761), Biotin carboxylase, C-terminal
(InterPro:IPR005482), Single hybrid motif
(InterPro:IPR011053), Carbamoyl phosphate synthetase,
large subunit, ATP-binding (InterPro:IPR005479),
Acetyl-CoA carboxylase, central region
(InterPro:IPR013537), Biotin carboxylation domain
(InterPro:IPR011764), Biotin-binding site
(InterPro:IPR001882), ATP-grasp fold, subdomain 2
(InterPro:IPR013816), Acetyl-coenzyme A
carboxyltransferase, C-terminal (InterPro:IPR011763),
Pre-ATP-grasp fold (InterPro:IPR013817), Rudiment single
hybrid motif (InterPro:IPR011054); BEST Arabidopsis
thaliana protein match is: acetyl-CoA carboxylase 2
(TAIR:AT1G36180.1); Has 35904 Blast hits to 31362 proteins
in 3745 species: Archae - 652; Bacteria - 22267; Metazoa -
1934; Fungi - 1046; Plants - 1042; Viruses - 0; Other
Eukaryotes - 8963 (source: NCBI BLink)."
/db_xref="Araport:AT1G36160"
/db_xref="GeneID:840521"
/db_xref="TAIR:AT1G36160"
ORIGIN
1 magsvngnhs avgpginyet vsqvdefcka lrgkrpihsi lianngmaav kfirsvrtwa
61 yetfgtekai llvgmatped mrinaehiri adqfvevpgg tnnnnyanvq livemaevtr
121 vdavwpgwgh asenpelpda ldakgiiflg ppassmaalg dkigssliaq aadvptlpws
181 gshvkippns nlvtipeeiy rqacvyttee aiascqvvgy pamikaswgg ggkgirkvhn
241 ddevralfkq vqgevpgspi fimkvasqsr hlevqllcdk hgnvsalhsr dcsvqrrhqk
301 iieegpitva ppetvkkleq aarrlaksvn yvgaatveyl ysmdtgeyyf lelnprlqve
361 hpvtewiaei nlpaaqvavg mgiplwqipe irrfygiehg ggydswrkts vvafpfdfdk
421 aqsirpkghc vavrvtsedp ddgfkptsgr vqelsfkskp nvwayfsvks gggihefsds
481 qfghvfafge sralaianmv lglkeiqirg eirtnvdyti dllhasdyrd nkihtgwlds
541 riamrvraer ppwylsvvgg alykasatsa avvsdyvgyl ekgqippkhi slvhsqvsln
601 iegskytidv vrggsgtyrl rmnksevvae ihtlrdggll mqldgkshvi yaeeeaagtr
661 llidgrtcll qndhdpsklm aetpcklmry lisdnsnida dtpyaevevm kmcmpllspa
721 sgvihfkmse gqamqageli anldlddpsa vrkaepfhgs fprlglptai sgrvhqrcaa
781 tlnaarmila gyehkvdevv qdllncldsp elpflqwqec favlatrlpk nlrnmlesky
841 refesisrns lttdfpakll kgileahlss cdekergale rlieplmsla ksyeggresh
901 arvivhslfe eylsveelfn dnmladvier mrqlykkdll kivdivlshq giknknklvl
961 rlmeqlvypn paayrdklir fstlnhtnys elalkasqll eqtklselrs niarslsele
1021 mftedgenmd tpkrksaine riedlvsasl avedalvglf dhsdhtlqrr vvetyirrly
1081 qpyvvkdsvr mqwhrsglla swefleehme rkniglddpd tsekglvekr skrkwgamvi
1141 ikslqflpsi isaalretkh ndyetagapl sgnmmhiaiv ginnqmsllq dsgdedqaqe
1201 rvnklakilk eeevssslcs agvgviscii qrdegrtpmr hsfhwslekq yyveepllrh
1261 lepplsiyle ldklkgysni qytpsrdrqw hlytvtdkpv pikrmflrsl vrqatmndgf
1321 ilqqgqdkql sqtlismaft skcvlrslmd ameelelnah naamkpdhah mflcilreqq
1381 iddlvpfprr vevnaedeet tvemileeaa reihrsvgvr mhrlgvcewe vrlwlvssgl
1441 acgawrvvva nvtgrtctvh iyrevetpgr nsliyhsitk kgplhetpis dqykplgyld
1501 rqrlaarrsn ttycydfpla fgtalellwa sqhpgvkkpy kdtlinvkel vfskpegssg
1561 tsldlverpp glndfgmvaw cldmstpefp mgrkllvian dvtfkagsfg predafflav
1621 telacakklp liylaansga rlgvaeevka cfkvgwsdei spengfqyiy lspedherig
1681 ssviahevkl ssgetrwvid tivgkedgig venltgsgai agayskayne tftltfvsgr
1741 tvgigaylar lgmrciqrld qpiiltgfst lnkllgrevy sshmqlggpk imgtngvvhl
1801 tvsddlegvs ailnwlsyip ayvggplpvl apldpperiv eyvpenscdp raaiagvkdn
1861 tgkwlggifd knsfietleg wartvvtgra klggipvgvv avetqtvmqi ipadpgqlds
1921 hervvpqagq vwfpdsaakt aqalmdfnre elplfilanw rgfsggqrdl fegilqagst
1981 ivenlrtyrq pvfvyipmmg elrggawvvv dsqinsdyve myadetargn vlepegtiei
2041 kfrtkellec mgrldqklis lkaklqdakq seayaniell qqqikarekq llpvyiqiat
2101 kfaelhdtsm rmaakgviks vvewsgsrsf fykklnrria esslvknvre asgdnlayks
2161 smrliqdwfc nsdiakgkee awtddqvfft wkdnvsnyel klselraqkl lnqlaeigns
2221 sdlqalpqgl anllnkveps kreelvaair kvlg
//
