LOCUS NP_217040 3069 aa linear CON 14-DEC-2017
DEFINITION fatty acid synthase [Mycobacterium tuberculosis H37Rv].
ACCESSION NP_217040
VERSION NP_217040.1
DBLINK BioProject: PRJNA57777
Assembly: GCF_000195955.2
DBSOURCE REFSEQ: accession NC_000962.3
KEYWORDS RefSeq.
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis
complex.
REFERENCE 1
AUTHORS Lew,J.M., Kapopoulou,A., Jones,L.M. and Cole,S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91 (1), 1-7 (2011)
PUBMED 20980199
REFERENCE 2
AUTHORS Camus,J.C., Pryor,M.J., Medigue,C. and Cole,S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148 (PT 10), 2967-2973 (2002)
PUBMED 12368430
REFERENCE 3
AUTHORS Cole,S.T., Brosch,R., Parkhill,J., Garnier,T., Churcher,C.,
Harris,D., Gordon,S.V., Eiglmeier,K., Gas,S., Barry,C.E. III,
Tekaia,F., Badcock,K., Basham,D., Brown,D., Chillingworth,T.,
Connor,R., Davies,R., Devlin,K., Feltwell,T., Gentles,S.,
Hamlin,N., Holroyd,S., Hornsby,T., Jagels,K., Krogh,A., McLean,J.,
Moule,S., Murphy,L., Oliver,K., Osborne,J., Quail,M.A.,
Rajandream,M.A., Rogers,J., Rutter,S., Seeger,K., Skelton,J.,
Squares,R., Squares,S., Sulston,J.E., Taylor,K., Whitehead,S. and
Barrell,B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393 (6685), 537-544 (1998)
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 4 (residues 1 to 3069)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (06-FEB-2013) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (residues 1 to 3069)
AUTHORS Lew,J.M.
TITLE Direct Submission
JOURNAL Submitted (18-DEC-2012) Lew J., Ecole Polytechnique Federale de
Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss Institute
of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva 4,
SWITZERLAND
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence is identical to CCP45318.
RefSeq Category: Reference Genome
FGS: First Genome sequenced
MOD: Model Organism
TYS: Designated Type Strain
UPR: UniProt Genome
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..3069
/organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/type_material="type strain of Mycobacterium tuberculosis"
/db_xref="taxon:83332"
Protein 1..3069
/product="fatty acid synthase"
/calculated_mol_wt=326125
Region 31..363
/region_name="FabD"
/note="Malonyl CoA-acyl carrier protein transacylase
[Lipid transport and metabolism]; COG0331"
/db_xref="CDD:223408"
Region 384..1090
/region_name="COG4981"
/note="Enoyl reductase domain of yeast-type FAS1 [Lipid
transport and metabolism]"
/db_xref="CDD:227314"
Region 1211..1330
/region_name="FAS_MaoC"
/note="the MaoC-like hot dog fold of the fatty acid
synthase, beta subunit. Other enzymes with this fold
include MaoC dehydratase,
Hydratase-Dehydrogenase-Epimerase protein (HDE), and
17-beta-hydroxysteriod dehydrogenase (HSD); cd03447"
/db_xref="CDD:239531"
Site order(1224,1229,1231,1234,1249,1252..1253)
/site_type="active"
/note="putative active site [active]"
/db_xref="CDD:239531"
Site order(1229,1231,1234,1252)
/site_type="active"
/note="putative catalytic site [active]"
/db_xref="CDD:239531"
Region 1329..1722
/region_name="FabD"
/note="Malonyl CoA-acyl carrier protein transacylase
[Lipid transport and metabolism]; COG0331"
/db_xref="CDD:223408"
Region 1743..2585
/region_name="FabG2"
/note="3-oxoacyl-ACP reductase domain of yeast-type FAS1
[Lipid transport and metabolism]; COG4982"
/db_xref="CDD:227315"
Region 2600..2992
/region_name="FabB"
/note="3-oxoacyl-(acyl-carrier-protein) synthase [Lipid
transport and metabolism, Secondary metabolites
biosynthesis, transport and catabolism]; COG0304"
/db_xref="CDD:223381"
CDS 1..3069
/gene="fas"
/locus_tag="Rv2524c"
/coded_by="complement(NC_000962.3:2840123..2849332)"
/experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
/experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00606"
/note="Fas (fatty acid synthetase)"
/transl_table=11
/db_xref="GeneID:887704"
CONTIG join(WP_003900843.1:1..3069)
ORIGIN
1 mtihehdrvs adrggdspht thalvdrlma gepyavafgg qgsawletle elvsatgiet
61 elatlvgeae llldpvtdel ivvrpigfep lqwvralaae dpvpsdkhlt saavsvpgvl
121 ltqiaatral arqgmdlvat ppvamaghsq gvlavealka ggardvelfa laqligaagt
181 lvarrrgisv lgdrppmvsv tnadperigr lldefaqdvr tvlppvlsir ngrravvitg
241 tpeqlsrfel ycrqisekee adrknkvrgg dvfspvfepv qvevgfhtpr lsdgidivag
301 waekagldva lareladail irkvdwvdei trvhaagarw ildlgpgdil trltapvirg
361 lgigivpaat rggqrnlftv gatpevaraw ssyaptvvrl pdgrvklstk ftrltgrspi
421 llagmtpttv dakivaaaan aghwaelagg gqvteeifgn rieqmaglle pgrtyqfnal
481 fldpylwklq vggkrlvqka rqsgaaidgv visagipdld eavelidelg digishvvfk
541 pgtieqirsv iriatevptk pvimhveggr agghhswedl ddlllatyse lrsranitvc
601 vgggigtprr aaeylsgrwa qaygfplmpi dgilvgtaam atkesttsps vkrmlvdtqg
661 tdqwisagka qggmassrsq lgadiheidn sasrcgrlld evagdaeava errdeiiaam
721 aktakpyfgd vadmtylqwl rryvelaige gnstadtasv gspwladtwr drfeqmlqra
781 earlhpqdfg piqtlftdag lldnpqqaia allarypdae tvqlhpadvp ffvtlcktlg
841 kpvnfvpvid qdvrrwwrsd slwqahdary dadavciipg tasvagitrm depvgelldr
901 feqaaidevl gagvepkdva srrlgradva gplavvldap dvrwagrtvt npvhriadpa
961 ewqvhdgpen prathsstga rlqthgddva lsvpvsgtwv dirftlpant vdggtpviat
1021 edatsamrtv laiaagvdsp eflpavangt atltvdwhpe rvadhtgvta tfgeplapsl
1081 tnvpdalvgp cwpavfaaig savtdtgepv vegllslvhl dhaarvvgql ptvpaqltvt
1141 ataanatdtd mgrvvpvsvv vtgadgavia tleerfailg rtgsaeladp araggavsan
1201 atdtprrrrr dvtitapvdm rpfavvsgdh npihtdraaa llaglespiv hgmwlsaaaq
1261 havtatdgqa rpparlvgwt arflgmvrpg devdfrverv gidqgaeivd vaarvgsdlv
1321 msasarlaap ktvyafpgqg iqhkgmgmev rarskaarkv wdtadkftrd tlgfsvlhvv
1381 rdnptsiias gvhyhhpdgv lyltqftqva matvaaaqva emreqgafve gaiacghsvg
1441 eytalacvtg iyqleallem vfhrgskmhd ivprdelgrs nyrlaairps qidlddadvp
1501 afvagiaest gefleivnfn lrgsqyaiag tvrglealea everrreltg grrsfilvpg
1561 idvpfhsrvl rvgvaefrrs ldrvmprdad pdliigryip nlvprlftld rdfiqeirdl
1621 vpaepldeil adydtwlrer premartvfi ellawqfasp vrwietqdll fieeaagglg
1681 verfveigvk ssptvaglat ntlklpeyah stvevlnaer daavlfatdt dpepepeede
1741 pvaespapdv vseaapvapa assagprpdd lvfdaadatl alialsakmr idqieeldsi
1801 esitdgassr rnqllvdlgs elnlgaidga aesdlaglrs qvtklartyk pygpvlsdai
1861 ndqlrtvlgp sgkrpgaiae rvkktwelge gwakhvtvev algtregssv rggamghlhe
1921 galadaasvd kvidaavasv aarqgvsval psagsgggat idaaalseft dqitgregvl
1981 asaarlvlgq lglddpvnal paapdselid lvtaelgadw prlvapvfdp kkavvfddrw
2041 asaredlvkl wltdegdida dwprlaerfe gaghvvatqa twwqgkslaa grqihaslyg
2101 riaagaenpe pgryggevav vtgaskgsia asvvarlldg gatviattsk ldeerlafyr
2161 tlyrdharyg aalwlvaanm asysdvdalv ewigteqtes lgpqsihikd aqtptllfpf
2221 aaprvvgdls eagsraemem kvllwavqrl igglstigae rdiasrlhvv lpgspnrgmf
2281 ggdgaygeak saldavvsrw haesswaarv slahaligwt rgtglmghnd aivaaveeag
2341 vttystdema allldlcdae skvaaarspi kadltgglae anldmaelaa kareqmsaaa
2401 avdedaeapg aiaalpsppr gftpapppqw ddldvdpadl vvivggaeig pygssrtrfe
2461 mevenelsaa gvlelawttg lirweddpqp gwydtesgem vdeselvqry hdavvqrvgi
2521 refvddgaid pdhaspllvs vflekdfafv vsseadaraf vefdpehtvi rpvpdstdwq
2581 virkagteir vprktklsrv vggqiptgfd ptvwgisadm agsidrlavw nmvatvdafl
2641 ssgfspaevm ryvhpslvan tqgtgmgggt smqtmyhgnl lgrnkpndif qevlpniiaa
2701 hvvqsyvgsy gamihpvaac ataavsveeg vdkirlgkaq lvvagglddl tlegiigfgd
2761 maatadtsmm cgrgihdskf srpndrrrlg fveaqgggti llargdlalr mglpvlavva
2821 faqsfgdgvh tsipapglga lgagrggkds plaralaklg vaaddvavis khdtstland
2881 pnetelherl adalgrsega plfvvsqksl tghakggaav fqmmglcqil rdgvippnrs
2941 ldcvddelag sahfvwvrdt lrlggkfplk agmltslgfg hvsglvalvh pqafiasldp
3001 aqradyqrra darllagqrr lasaiaggap myqrpgdrrf dhhaperpqe asmllnpaar
3061 lgdgeayig
//
