LOCUS NP_253617 358 aa linear CON 24-JAN-2019
DEFINITION biosynthetic alanine racemase [Pseudomonas aeruginosa PAO1].
ACCESSION NP_253617
VERSION NP_253617.1
DBLINK BioProject: PRJNA57945
Assembly: GCF_000006765.1
DBSOURCE REFSEQ: accession NC_002516.2
KEYWORDS RefSeq.
SOURCE Pseudomonas aeruginosa PAO1
ORGANISM Pseudomonas aeruginosa PAO1
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
Pseudomonadaceae; Pseudomonas.
REFERENCE 1 (residues 1 to 358)
AUTHORS Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D.,
Hancock,R.E. and Brinkman,F.S.
TITLE Pseudomonas Genome Database: facilitating user-friendly,
comprehensive comparisons of microbial genomes
JOURNAL Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009)
PUBMED 18978025
REFERENCE 2 (residues 1 to 358)
AUTHORS Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E.
TITLE Defining the Pseudomonas aeruginosa SOS response and its role in
the global response to the antibiotic ciprofloxacin
JOURNAL J. Bacteriol. 188 (20), 7101-7110 (2006)
PUBMED 17015649
REFERENCE 3 (residues 1 to 358)
AUTHORS Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M.
TITLE Cystic fibrosis sputum supports growth and cues key aspects of
Pseudomonas aeruginosa physiology
JOURNAL J. Bacteriol. 187 (15), 5267-5277 (2005)
PUBMED 16030221
REFERENCE 4 (residues 1 to 358)
AUTHORS Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J.,
Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C.
TITLE A cystic fibrosis epidemic strain of Pseudomonas aeruginosa
displays enhanced virulence and antimicrobial resistance
JOURNAL J. Bacteriol. 187 (14), 4908-4920 (2005)
PUBMED 15995206
REFERENCE 5 (residues 1 to 358)
AUTHORS Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G.,
Iglewski,B.H. and Passador,L.
TITLE Effect of anaerobiosis and nitrate on gene expression in
Pseudomonas aeruginosa
JOURNAL Infect. Immun. 73 (6), 3764-3772 (2005)
PUBMED 15908409
REFERENCE 6 (residues 1 to 358)
AUTHORS Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M.,
Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M.
TITLE Screening for quorum-sensing inhibitors (QSI) by use of a novel
genetic system, the QSI selector
JOURNAL J. Bacteriol. 187 (5), 1799-1814 (2005)
PUBMED 15716452
REFERENCE 7 (residues 1 to 358)
AUTHORS Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D.,
Ching,W.K., Hancock,R.E. and Brinkman,F.S.
TITLE Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating
community-based, continually updated, genome annotation
JOURNAL Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005)
PUBMED 15608211
REFERENCE 8 (residues 1 to 358)
AUTHORS Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and
Iglewski,B.H.
TITLE Microarray analysis of Pseudomonas aeruginosa quorum-sensing
regulons: effects of growth phase and environment
JOURNAL J. Bacteriol. 185 (7), 2080-2095 (2003)
PUBMED 12644477
REFERENCE 9 (residues 1 to 358)
AUTHORS Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P.
TITLE Identification, timing, and signal specificity of Pseudomonas
aeruginosa quorum-controlled genes: a transcriptome analysis
JOURNAL J. Bacteriol. 185 (7), 2066-2079 (2003)
PUBMED 12644476
REFERENCE 10 (residues 1 to 358)
AUTHORS Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M.,
Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y.,
Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.,
Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J.,
Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V.
TITLE Complete genome sequence of Pseudomonas aeruginosa PA01, an
opportunistic pathogen
JOURNAL Nature 406 (6799), 959-964 (2000)
PUBMED 10984043
REFERENCE 11 (residues 1 to 358)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (06-OCT-2010) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 12 (residues 1 to 358)
AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
TITLE Direct Submission
JOURNAL Submitted (08-SEP-2010) Department of Molecular Biology and
Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
British Columbia V5A 1S6, Canada
REMARK protein update by submitter
REFERENCE 13 (residues 1 to 358)
AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
TITLE Direct Submission
JOURNAL Submitted (02-OCT-2008) Department of Molecular Biology and
Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
British Columbia V5A 1S6, Canada
REMARK protein update by submitter
REFERENCE 14 (residues 1 to 358)
AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
TITLE Direct Submission
JOURNAL Submitted (05-JUL-2006) Department of Molecular Biology and
Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
British Columbia V5A 1S6, Canada
REMARK Sequence update by submitter
REFERENCE 15 (residues 1 to 358)
AUTHORS Ung,K.S., Hancock,R.E. and Brinkman,F.S.
CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
TITLE Direct Submission
JOURNAL Submitted (04-FEB-2003) Department of Molecular Biology and
Biochemistry, Simon Fraser University, 8888 University Dr.,
Burnaby, British Columbia V5A 1S6, Canada
REFERENCE 16 (residues 1 to 358)
AUTHORS Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J.,
Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E.,
Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N.,
Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H.,
Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H.,
Hancock,R.E.W., Lory,S. and Olson,M.V.
CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
TITLE Direct Submission
JOURNAL Submitted (16-MAY-2000) Department of Medicine and Genetics,
University of Washington Genome Center, University Of Washington,
Box 352145, Seattle, WA 98195, USA
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence is identical to AAG08315.
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..358
/organism="Pseudomonas aeruginosa PAO1"
/strain="PAO1"
/db_xref="taxon:208964"
Protein 1..358
/product="biosynthetic alanine racemase"
/calculated_mol_wt=38180
Region 3..356
/region_name="PLPDE_III_AR_proteobact"
/note="Type III Pyridoxal 5-phosphate (PLP)-Dependent
Enzymes, Proteobacterial Alanine Racemases; cd06827"
/db_xref="CDD:143500"
Site order(32,34,38,79,123,130,157,159,193..195,209..212,342)
/site_type="active"
/db_xref="CDD:143500"
Site order(32,34,38,79,159,193..194,209,211..212,342)
/site_type="other"
/note="pyridoxal 5'-phosphate (PLP) binding site [chemical
binding]"
/db_xref="CDD:143500"
Site order(34,38,130,159,342)
/site_type="other"
/note="substrate binding site [chemical binding]"
/db_xref="CDD:143500"
Site order(34,254)
/site_type="active"
/note="catalytic residues [active]"
/db_xref="CDD:143500"
Site order(241,244,250..251,253..255,268,273,279,301,303,340,
342..343,348,351)
/site_type="other"
/note="dimer interface [polypeptide binding]"
/db_xref="CDD:143500"
CDS 1..358
/gene="alr"
/locus_tag="PA4930"
/coded_by="complement(NC_002516.2:5533017..5534093)"
/note="Product name confidence: class 2 (High similarity
to functionally studied protein)"
/transl_table=11
/db_xref="GeneID:878646"
CONTIG join(WP_003112284.1:1..358)
ORIGIN
1 mrplvatvdl sairhnyala krcapqrqaf avvkanaygh garevvtalh ddadgfavac
61 leeaaevral hasarillle gcfeaseyal agqlrldlvi qgaeqgeafl aagldiplnv
121 wlkldsgmhr lgfdpaalra wharlrshpg vrelnlishf acadernhpl teqqlesflg
181 lldldfdqrs lansaavlti paahmdwlrp gimlygstpl adlsaaelgl kpamslgaql
241 islrevavge svgygatwia erparigtvs cgyadgyprt apagtpvlvg grrailagrv
301 smdmlavdls dlpearvgdp velwgaglsv devaracgtl gyellskvta rvprrysh
//
