LOCUS NP_439893 395 aa linear PRI 27-DEC-2022
DEFINITION tripartite motif-containing protein 10 isoform 2 [Homo sapiens].
ACCESSION NP_439893
VERSION NP_439893.2
DBSOURCE REFSEQ: accession NM_052828.3
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 395)
AUTHORS Guo M, Cao W, Chen S, Tian R, Wang L, Liu Q, Zhang L, Wang Z, Zhao
M, Lu Q and Zhu H.
TITLE TRIM10 binds to IFN-alpha/beta receptor 1 to negatively regulate
type I IFN signal transduction
JOURNAL Eur J Immunol 51 (7), 1762-1773 (2021)
PUBMED 33811647
REMARK GeneRIF: TRIM10 binds to IFN-alpha/beta receptor 1 to negatively
regulate type I IFN signal transduction.
REFERENCE 2 (residues 1 to 395)
AUTHORS Xi X, Bao Y, Zhou Y, Chen Y, Zhong X, Liao J, Zhou J, Xu S, Cao Z,
Hu K, Hu Y, He X, Zhou L, Lin H and Wu Q.
TITLE Oncogenic gene TRIM10 confers resistance to cisplatin in
osteosarcoma cells and activates the NF-kappaB signaling pathway
JOURNAL Cell Biol Int 45 (1), 74-82 (2021)
PUBMED 32997424
REMARK GeneRIF: Oncogenic gene TRIM10 confers resistance to cisplatin in
osteosarcoma cells and activates the NF-kappaB signaling pathway.
REFERENCE 3 (residues 1 to 395)
AUTHORS Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
TITLE Extensive disruption of protein interactions by genetic variants
across the allele frequency spectrum in human populations
JOURNAL Nat Commun 10 (1), 4141 (2019)
PUBMED 31515488
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 395)
AUTHORS Mick E, McGough J, Deutsch CK, Frazier JA, Kennedy D and Goldberg
RJ.
TITLE Genome-wide association study of proneness to anger
JOURNAL PLoS One 9 (1), e87257 (2014)
PUBMED 24489884
REMARK Publication Status: Online-Only
REFERENCE 5 (residues 1 to 395)
AUTHORS Fellay J, Ge D, Shianna KV, Colombo S, Ledergerber B, Cirulli ET,
Urban TJ, Zhang K, Gumbs CE, Smith JP, Castagna A, Cozzi-Lepri A,
De Luca A, Easterbrook P, Gunthard HF, Mallal S, Mussini C, Dalmau
J, Martinez-Picado J, Miro JM, Obel N, Wolinsky SM, Martinson JJ,
Detels R, Margolick JB, Jacobson LP, Descombes P, Antonarakis SE,
Beckmann JS, O'Brien SJ, Letvin NL, McMichael AJ, Haynes BF,
Carrington M, Feng S, Telenti A and Goldstein DB.
CONSRTM NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
TITLE Common genetic variation and the control of HIV-1 in humans
JOURNAL PLoS Genet 5 (12), e1000791 (2009)
PUBMED 20041166
REFERENCE 6 (residues 1 to 395)
AUTHORS Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L,
Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci
S, Pelicci PG and Ballabio A.
TITLE The tripartite motif family identifies cell compartments
JOURNAL EMBO J 20 (9), 2140-2151 (2001)
PUBMED 11331580
REFERENCE 7 (residues 1 to 395)
AUTHORS Orimo A, Yamagishi T, Tominaga N, Yamauchi Y, Hishinuma T, Okada K,
Suzuki M, Sato M, Nogi Y, Suzuki H, Inoue S, Yoshimura K, Shimizu Y
and Muramatsu M.
TITLE Molecular cloning of testis-abundant finger Protein/Ring finger
protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on
the class I region of the human MHC
JOURNAL Biochem Biophys Res Commun 276 (1), 45-51 (2000)
PUBMED 11006080
REFERENCE 8 (residues 1 to 395)
AUTHORS Harada H, Harada Y, O'Brien DP, Rice DS, Naeve CW and Downing JR.
TITLE HERF1, a novel hematopoiesis-specific RING finger protein, is
required for terminal differentiation of erythroid cells
JOURNAL Mol Cell Biol 19 (5), 3808-3815 (1999)
PUBMED 10207104
REFERENCE 9 (residues 1 to 395)
AUTHORS Henry J, Ribouchon M, Depetris D, Mattei M, Offer C, Tazi-Ahnini R
and Pontarotti P.
TITLE Cloning, structural analysis, and mapping of the B30 and B7
multigenic families to the major histocompatibility complex (MHC)
and other chromosomal regions
JOURNAL Immunogenetics 46 (5), 383-395 (1997)
PUBMED 9271628
REFERENCE 10 (residues 1 to 395)
AUTHORS Goei VL, Parimoo S, Capossela A, Chu TW and Gruen JR.
TITLE Isolation of novel non-HLA gene fragments from the hemochromatosis
region (6p21.3) by cDNA hybridization selection
JOURNAL Am J Hum Genet 54 (2), 244-251 (1994)
PUBMED 8304341
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL669914.2, BC093926.1 and AL360163.1.
On Sep 22, 2007 this sequence version replaced NP_439893.1.
Summary: The protein encoded by this gene is a member of the
tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
and a coiled-coil region. This protein localizes to cytoplasmic
bodies. Studies in mice suggest that this protein plays a role in
terminal differentiation of erythroid cells. Alternate splicing of
this gene generates two transcript variants encoding different
isoforms. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) uses an alternate splice site
that results in the introduction of a 539 nt intron between a 3'
penultimate and 3' terminal exon, compared to the 3' terminal exon
of variant 1. This results in a frameshift and introduction of a
novel stop codon. Isoform 2 has a distinct C-terminus and is 86 aa
shorter than isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because transcript sequence consistent with
the reference genome assembly was not available for all regions of
the RefSeq transcript. The extent of this transcript is supported
by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF220123.1, BC113419.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1970526, SAMEA2149004
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..395
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p22.1"
Protein 1..395
/product="tripartite motif-containing protein 10 isoform
2"
/note="hematopoietic RING finger 1; ring finger protein 9;
tripartite motif protein 10; tripartite motif-containing
protein 10; Zn-finger protein; B30-RING finger protein"
/calculated_mol_wt=45121
Region 9..69
/region_name="RING-HC_TRIM10_C-IV"
/note="RING finger, HC subclass, found in tripartite
motif-containing protein 10 (TRIM10) and similar proteins;
cd16593"
/db_xref="CDD:438255"
Region 97..135
/region_name="Bbox_SF"
/note="B-box-type zinc finger superfamily; cl00034"
/db_xref="CDD:444664"
Region 143..>217
/region_name="BBC"
/note="B-Box C-terminal domain; smart00502"
/db_xref="CDD:128778"
Region 309..>368
/region_name="SPRY"
/note="SPRY domain; cl02614"
/db_xref="CDD:445854"
CDS 1..395
/gene="TRIM10"
/gene_synonym="HERF1; RFB30; RNF9"
/coded_by="NM_052828.3:354..1541"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="CCDS:CCDS4676.1"
/db_xref="GeneID:10107"
/db_xref="HGNC:HGNC:10072"
/db_xref="MIM:605701"
ORIGIN
1 masaasvtsl adevncpicq gtlrepvtid cghnfcracl tryceipgpd leesptcplc
61 kepfrpgsfr pnwqlanvve nierlqlvst lglgeedvcq ehgekiyffc eddemqlcvv
121 creagehath tmrfledaaa pyreqihkcl kclrkereei qeiqsrenkr mqvlltqvst
181 krqqvisefa hlrkfleeqq sillaqlesq dgdilrqrde fdllvageic rfsalieele
241 eknerparel ltdirstlir cetrkcrkpv avspelgqri rdfpqqalpl qremkmflek
301 lcfeldyepa hisldpqtsh pklllsedhq raqfsykwqn spdnpqrfdr atcvlahtgi
361 tggrhtwvwm arvpgdsgcc qfcsppsvlg tevaa
//
