LOCUS NP_443160 804 aa linear PRI 25-DEC-2022
DEFINITION SET and MYND domain-containing protein 4 [Homo sapiens].
ACCESSION NP_443160 XP_056082
VERSION NP_443160.2
DBSOURCE REFSEQ: accession NM_052928.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 804)
AUTHORS Xiao D, Wang H, Hao L, Guo X, Ma X, Qian Y, Chen H, Ma J, Zhang J,
Sheng W, Shou W, Huang G and Ma D.
TITLE The roles of SMYD4 in epigenetic regulation of cardiac development
in zebrafish
JOURNAL PLoS Genet 14 (8), e1007578 (2018)
PUBMED 30110327
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 804)
AUTHORS O'Seaghdha CM, Yang Q, Glazer NL, Leak TS, Dehghan A, Smith AV, Kao
WH, Lohman K, Hwang SJ, Johnson AD, Hofman A, Uitterlinden AG, Chen
YD, Brown EM, Siscovick DS, Harris TB, Psaty BM, Coresh J, Gudnason
V, Witteman JC, Liu YM, Kestenbaum BR, Fox CS and Kottgen A.
CONSRTM GEFOS Consortium
TITLE Common variants in the calcium-sensing receptor gene are associated
with total serum calcium levels
JOURNAL Hum Mol Genet 19 (21), 4296-4303 (2010)
PUBMED 20705733
REFERENCE 3 (residues 1 to 804)
AUTHORS Hu L, Zhu YT, Qi C and Zhu YJ.
TITLE Identification of Smyd4 as a potential tumor suppressor gene
involved in breast cancer development
JOURNAL Cancer Res 69 (9), 4067-4072 (2009)
PUBMED 19383909
REMARK GeneRIF: Smyd4, as a potential tumor suppressor, plays a critical
role in breast carcinogenesis at least partly through inhibiting
the expression of Pdgfr-alpha.
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC130689.8, AK095369.1, CR987176.1, DB219337.1, BC035077.2,
CN352185.1, AV700545.1, AL137345.1 and BM676597.1.
On Aug 30, 2007 this sequence version replaced NP_443160.1.
##Evidence-Data-START##
Transcript exon combination :: SRR1803617.99701.1,
SRR1803616.38012.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000305513.12/ ENSP00000304360.7
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..804
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p13.3"
Protein 1..804
/product="SET and MYND domain-containing protein 4"
/calculated_mol_wt=89094
Region 68..96
/region_name="TPR repeat"
/note="TPR repeat [structural motif]"
/db_xref="CDD:276809"
Site order(69,72..73,76..77,79,103,110..111,114..115,117..118,
144,147..148,151..152,155)
/site_type="other"
/note="putative protein binding surface [polypeptide
binding]"
/db_xref="CDD:276809"
Region <72..>237
/region_name="3a0801s09"
/note="mitochondrial precursor proteins import receptor
(72 kDa mitochondrial outermembrane protein)
(mitochondrial import receptor for the ADP/ATP carrier)
(translocase of outermembrane tom70); TIGR00990"
/db_xref="CDD:273380"
Region 101..135
/region_name="TPR repeat"
/note="TPR repeat [structural motif]"
/db_xref="CDD:276809"
Region 143..171
/region_name="TPR repeat"
/note="TPR repeat [structural motif]"
/db_xref="CDD:276809"
Region 239..>269
/region_name="SET"
/note="SET (Su(var)3-9, Enhancer-of-zeste, Trithorax)
domain superfamily; cl40432"
/db_xref="CDD:394802"
Region 296..335
/region_name="zf-MYND"
/note="MYND finger; pfam01753"
/db_xref="CDD:426410"
Region 404..602
/region_name="SET_SMYD4"
/note="SET domain (including iSET domain and post-SET
domain) found in SET and MYND domain-containing protein 4
(SMYD4) and similar proteins; cd10536"
/db_xref="CDD:380934"
Site order(406,493,499,501,503..509,536..540,548,560,571..576,
595..599)
/site_type="active"
/note="putative active site [active]"
/db_xref="CDD:380934"
Site order(503..506,536..540,573,595..599)
/site_type="other"
/note="putative SAM binding site"
/db_xref="CDD:380934"
Site order(517..518,526,536,572..573,575)
/site_type="other"
/note="putative polypeptide substrate binding site
[polypeptide binding]"
/db_xref="CDD:380934"
Site order(542,597,599,602)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:380934"
Region 660..726
/region_name="TPR_12"
/note="Tetratricopeptide repeat; pfam13424"
/db_xref="CDD:315987"
Region 698..771
/region_name="TPR_12"
/note="Tetratricopeptide repeat; pfam13424"
/db_xref="CDD:315987"
CDS 1..804
/gene="SMYD4"
/gene_synonym="ZMYND21"
/coded_by="NM_052928.3:190..2604"
/db_xref="CCDS:CCDS11013.1"
/db_xref="GeneID:114826"
/db_xref="HGNC:HGNC:21067"
/db_xref="MIM:619134"
ORIGIN
1 mdlpvdewks yllqkwaslp tsvqvtista etlrdiflhs ssllqpedel flkrlskgyl
61 vgkdsdaplf yreegnkkfq ekdytgaavl yskgvshsrp ntedmslcha nrsaalfhlg
121 qyetclkdin raqthgyper lqpkimlrka eclvalgrlq easqtisdle rnftatpala
181 dvlpqtlqrn lhrlkmkmqe kdsltesfpa alaktledaa lreeneqlsn asssiglcvd
241 plkgrclvat kdilpgellv qedafvsvln pgelppphhg ldskwdtrvt ngdlychrcl
301 khtlatvpcd gcsyakycsq eclqqawely hrtecplggl lltlgvfchi alrltllvgf
361 edvrkiitkl cdkisnkdic lpesnnqvkt lnyglgesek ngnivetpip gcdingkyen
421 nynavfnllp htenhspehk flcalcvsal crqleaaslq aipterivns sqlkaavtpe
481 lcpdvtiwgv amlrhmlqlq cnaqamttiq htgpkgsivt dsrqvrlatg ifpvisllnh
541 scspntsvsf istvatiras qrirkgqeil hcygphksrm gvaerqqklr sqyffdcacp
601 acqteahrma agprweafcc nscgapmqgd dvlrcgsrsc aesavsrdhl vsrlqdlqqq
661 vrvaqkllrd geleravqrl sgcqrdaesf lwaehavvge iadglaraca algdwqksat
721 hlqrslyvve vrhgpssvem ghelfklaqi ffngfavpea lstiqkaeev lslhcgpwdd
781 eiqelqkmks clldlpptpv gpal
//
