LOCUS NP_524006 1639 aa linear INV 26-DEC-2023
DEFINITION laminin B2, isoform A [Drosophila melanogaster].
ACCESSION NP_524006
VERSION NP_524006.1
DBLINK BioProject: PRJNA164
BioSample: SAMN02803731
DBSOURCE REFSEQ: accession NM_079282.2
KEYWORDS RefSeq.
SOURCE Drosophila melanogaster (fruit fly)
ORGANISM Drosophila melanogaster
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE 1 (residues 1 to 1639)
AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
Strelets,V., Russo,S.M. and Gelbart,W.M.
CONSRTM FlyBase Consortium
TITLE Gene Model Annotations for Drosophila melanogaster: Impact of
High-Throughput Data
JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015)
PUBMED 26109357
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 1639)
AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
Russo,S.M. and Gelbart,W.M.
CONSRTM FlyBase Consortium
TITLE Gene Model Annotations for Drosophila melanogaster: The
Rule-Benders
JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015)
PUBMED 26109356
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 1639)
AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
TITLE The Release 6 reference sequence of the Drosophila melanogaster
genome
JOURNAL Genome Res 25 (3), 445-458 (2015)
PUBMED 25589440
REFERENCE 4 (residues 1 to 1639)
AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
TITLE Sequence finishing and mapping of Drosophila melanogaster
heterochromatin
JOURNAL Science 316 (5831), 1625-1628 (2007)
PUBMED 17569867
REFERENCE 5 (residues 1 to 1639)
AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
TITLE The Release 5.1 annotation of Drosophila melanogaster
heterochromatin
JOURNAL Science 316 (5831), 1586-1591 (2007)
PUBMED 17569856
REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE 6 (residues 1 to 1639)
AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
Ashburner,M. and Anxolabehere,D.
TITLE Combined evidence annotation of transposable elements in genome
sequences
JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005)
PUBMED 16110336
REFERENCE 7 (residues 1 to 1639)
AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
Celniker,S.E., Rubin,G.M. and Karpen,G.H.
TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun
assembly
JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002)
PUBMED 12537574
REFERENCE 8 (residues 1 to 1639)
AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
Rubin,G.M., Ashburner,M. and Celniker,S.E.
TITLE The transposable elements of the Drosophila melanogaster
euchromatin: a genomics perspective
JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002)
PUBMED 12537573
REFERENCE 9 (residues 1 to 1639)
AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
Rubin,G.M. and Lewis,S.E.
TITLE Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review
JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002)
PUBMED 12537572
REFERENCE 10 (residues 1 to 1639)
AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
Gibbs,R.A. and Rubin,G.M.
TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila
melanogaster euchromatic genome sequence
JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002)
PUBMED 12537568
REFERENCE 11 (residues 1 to 1639)
AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
TITLE The genome sequence of Drosophila melanogaster
JOURNAL Science 287 (5461), 2185-2195 (2000)
PUBMED 10731132
REFERENCE 12 (residues 1 to 1639)
AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
Smith,E., Yu,C. and Rubin,G.
CONSRTM Berkeley Drosophila Genome Project
TITLE Drosophila melanogaster release 4 sequence
JOURNAL Unpublished
REFERENCE 13 (residues 1 to 1639)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 14 (residues 1 to 1639)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 15 (residues 1 to 1639)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (10-NOV-2022) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 16 (residues 1 to 1639)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 17 (residues 1 to 1639)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 18 (residues 1 to 1639)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 19 (residues 1 to 1639)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 20 (residues 1 to 1639)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 21 (residues 1 to 1639)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (07-OCT-2015) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 22 (residues 1 to 1639)
AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
Park,S., Svirskas,R. and Karpen,G.
TITLE Direct Submission
JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
REMARK Direct Submission
REFERENCE 23 (residues 1 to 1639)
AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
Svirskas,R. and Rubin,G.
TITLE Direct Submission
JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
64-121, Berkeley, CA 94720, USA
REMARK Direct Submission
REFERENCE 24 (residues 1 to 1639)
AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
CONSRTM Drosophila Heterochromatin Genome Project
TITLE Direct Submission
JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE 25 (residues 1 to 1639)
AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
TITLE Direct Submission
JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
Rockville, MD 20850, USA
COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The
reference sequence is identical to AAF50238.
##Genome-Annotation-Data-START##
Annotation Provider :: FlyBase
Annotation Status :: Full annotation
Annotation Version :: Release 6.54
URL :: http://flybase.org
##Genome-Annotation-Data-END##
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..1639
/organism="Drosophila melanogaster"
/db_xref="taxon:7227"
/chromosome="3L"
/genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
Protein 1..1639
/product="laminin B2, isoform A"
/name="CG3322 gene product from transcript CG3322-RA"
/note="CG3322-PA; LanB2-PA; laminin gamma1; laminin
gamma2; LamininB2; laminin gamma-chain; lamininB; lethal
(3) 67BDb; laminin B2 subunit; anon-fast-evolving-2H3;
laminin gamma 1; knodel"
/calculated_mol_wt=182209
Region 61..296
/region_name="LamNT"
/note="Laminin N-terminal domain (domain VI); smart00136"
/db_xref="CDD:214532"
Region 298..347
/region_name="EGF_Lam"
/note="Laminin-type epidermal growth factor-like domain;
laminins are the major noncollagenous components of
basement membranes that mediate cell adhesion, growth
migration, and differentiation; the laminin-type epidermal
growth factor-like module occurs in...; cd00055"
/db_xref="CDD:238012"
Site order(299,301,308,322,324,333)
/site_type="active"
/note="EGF-like motif [active]"
/db_xref="CDD:238012"
Region 359..414
/region_name="Laminin_EGF"
/note="Laminin EGF domain; pfam00053"
/db_xref="CDD:395007"
Site order(359,361,368,384,387,396)
/site_type="active"
/note="EGF-like motif [active]"
/db_xref="CDD:238012"
Region 414..458
/region_name="EGF_Lam"
/note="Laminin-type epidermal growth factor-like domai;
smart00180"
/db_xref="CDD:214543"
Site order(414,416,426,432,434,443)
/site_type="active"
/note="EGF-like motif [active]"
/db_xref="CDD:238012"
Region 461..511
/region_name="Laminin_EGF"
/note="Laminin EGF domain; pfam00053"
/db_xref="CDD:395007"
Site order(461,463,475,482,484,493)
/site_type="active"
/note="EGF-like motif [active]"
/db_xref="CDD:238012"
Region 572..697
/region_name="LamB"
/note="Laminin B domain; smart00281"
/db_xref="CDD:214597"
Region 743..791
/region_name="EGF_Lam"
/note="Laminin-type epidermal growth factor-like domain;
laminins are the major noncollagenous components of
basement membranes that mediate cell adhesion, growth
migration, and differentiation; the laminin-type epidermal
growth factor-like module occurs in...; cd00055"
/db_xref="CDD:238012"
Site order(744,746,753,760,762,771)
/site_type="active"
/note="EGF-like motif [active]"
/db_xref="CDD:238012"
Region 793..836
/region_name="EGF_Lam"
/note="Laminin-type epidermal growth factor-like domai;
smart00180"
/db_xref="CDD:214543"
Region 847..897
/region_name="Laminin_EGF"
/note="Laminin EGF domain; pfam00053"
/db_xref="CDD:395007"
Site order(847,849,861,868,871,880)
/site_type="active"
/note="EGF-like motif [active]"
/db_xref="CDD:238012"
Region 902..953
/region_name="Laminin_EGF"
/note="Laminin EGF domain; pfam00053"
/db_xref="CDD:395007"
Site order(902,904,919,926,928,937)
/site_type="active"
/note="EGF-like motif [active]"
/db_xref="CDD:238012"
Region 956..1001
/region_name="EGF_Lam"
/note="Laminin-type epidermal growth factor-like domai;
smart00180"
/db_xref="CDD:214543"
Site order(956,958,968,975,977,986)
/site_type="active"
/note="EGF-like motif [active]"
/db_xref="CDD:238012"
Region 1004..1046
/region_name="Laminin_EGF"
/note="Laminin EGF domain; pfam00053"
/db_xref="CDD:395007"
Site order(1004,1006,1016,1022,1024,1033)
/site_type="active"
/note="EGF-like motif [active]"
/db_xref="CDD:238012"
Region <1054..1621
/region_name="SMC_prok_B"
/note="chromosome segregation protein SMC, common
bacterial type; TIGR02168"
/db_xref="CDD:274008"
CDS 1..1639
/gene="LanB2"
/locus_tag="Dmel_CG3322"
/gene_synonym="anon-EST:fe2H3; CG3322; CT11145;
Dmel\CG3322; DROLAMB2A; gamma1; knod; l(3)67BDb; Lam-B2;
lamB2; LAMB2A; laminin; lanB2; LM-B2/gamma; LMG1;
Lmgamma1"
/coded_by="NM_079282.2:253..5172"
/db_xref="FLYBASE:FBpp0076111"
/db_xref="GeneID:39118"
/db_xref="FLYBASE:FBgn0267348"
ORIGIN
1 mkrsrwshsg sstarlllig vlfascstai lgaqrppins agghelrgtt fmpalecydp
61 ygrpqkclpe finaayqlqi estntcgeqn dnhfciqtmn qnhkncefck yndhnpsflt
121 dlhdpqsptw wqsetmfegi qhpnyvnltl hlgksydity vrilfrsprp esftiykrts
181 esgpwipyqf ysatcrdtys lpdsrairkg egeahalcts eysdisplrd geiafstleg
241 rpsginfers gelqewvtat diritldrln tfgdelfgds qvlksyfyai sdiavgarck
301 cnghaskcvp stgmhgertl vcecrhntdg pdcdrclply ndlkwkrsts tevneckacn
361 cngladkcff danlfnrtgh gghcldcren rdgpncerck enfymrddgy cvncacdpvg
421 srslqcnshg kcqckpgvtg dkcdrcdnny yqfgphgcqq cgcdsggshq ntpacdtetg
481 icfckenveg rrcneckpgf fnldknnrfg ctpcfcyght secmtapgys ivsvtsnfnk
541 fkerwtaadl nqrevdikyn qysrsigtta qgnehvyfqa pdrflgdqra synrdlkfkl
601 qlvgqvantg vsdvilegag srislpifaq gngipdqgvk eytfrlhehh dyqwqpsqsa
661 rgflsilsnl taikiratys vqgeailddv elqtahrgaa ghpatwieqc tcpegylgqf
721 cescapgyrh sparggpfmp cipcdchgha dicdsetgrc icqhnthgdn cdqcakgfyg
781 nalggtpndc krcpcpndga clqinedtvi ctecpkgyfg srceqcsdgf fgdptgllge
841 vqtckscdcn gnvdpnavgn cnrttgeclk cihntagehc dqclsghfgd plalphgrcd
901 rcscyeagte qdeqsitrcd qvtgqcqckp nvigrdcgec qpgyfnirsg ngcenclcdp
961 vgsynstcdr ysgqchcrpg vmgqrcdqce nyfygfsseg ckpcecdesg skgfqcdqng
1021 qcpcndnveg rrcdrckenk ydrhrgcidc pdcynlvqda adlhraklfn lsqtldeiar
1081 tpvtnddefe aklkavqekv avlaqdardn sgdggqtyae viddlhkhld svrehlvsad
1141 kfqadangei drarqnytil dqitenakke lqqaldllnd egaqalarak eksvefgqqs
1201 eqisdisrea raladklese aqfdlknakd akdavekahq laksaidlql kigtelrsev
1261 glelshvkqs lgtvvqtske alrkanevyd taltllndvn rqtqpeidis qlkkdavaan
1321 eradellkqi telsnsngel fadfeteqel teallkraeq qqledielle rakaahdkat
1381 kaveqgdntl keanntyekl agfqsdvqrs sesaekalqt vpniekeiqn aeslisqaee
1441 aldganknan eakknaqeaq lkyaeqaskd aelirrkane tkvaarnlre eadqlnhrvk
1501 ltemdifkle esstkddnlv ddakrkvgqa kadtqeaqkq iekanadlta ikdelenlkd
1561 intgdldrle nrlatvegei nrvnltgrie kyreqrtiqk nlidkydael relkdevqni
1621 gliskalpds cfsrnrlep
//
