LOCUS NP_525040 2410 aa linear INV 26-DEC-2023
DEFINITION trithorax-related, isoform C [Drosophila melanogaster].
ACCESSION NP_525040
VERSION NP_525040.2
DBLINK BioProject: PRJNA164
BioSample: SAMN02803731
DBSOURCE REFSEQ: accession NM_080301.3
KEYWORDS RefSeq.
SOURCE Drosophila melanogaster (fruit fly)
ORGANISM Drosophila melanogaster
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE 1 (residues 1 to 2410)
AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
Strelets,V., Russo,S.M. and Gelbart,W.M.
CONSRTM FlyBase Consortium
TITLE Gene Model Annotations for Drosophila melanogaster: Impact of
High-Throughput Data
JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015)
PUBMED 26109357
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 2410)
AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
Russo,S.M. and Gelbart,W.M.
CONSRTM FlyBase Consortium
TITLE Gene Model Annotations for Drosophila melanogaster: The
Rule-Benders
JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015)
PUBMED 26109356
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 2410)
AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
TITLE The Release 6 reference sequence of the Drosophila melanogaster
genome
JOURNAL Genome Res 25 (3), 445-458 (2015)
PUBMED 25589440
REFERENCE 4 (residues 1 to 2410)
AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
TITLE Sequence finishing and mapping of Drosophila melanogaster
heterochromatin
JOURNAL Science 316 (5831), 1625-1628 (2007)
PUBMED 17569867
REFERENCE 5 (residues 1 to 2410)
AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
TITLE The Release 5.1 annotation of Drosophila melanogaster
heterochromatin
JOURNAL Science 316 (5831), 1586-1591 (2007)
PUBMED 17569856
REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE 6 (residues 1 to 2410)
AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
Ashburner,M. and Anxolabehere,D.
TITLE Combined evidence annotation of transposable elements in genome
sequences
JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005)
PUBMED 16110336
REFERENCE 7 (residues 1 to 2410)
AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
Celniker,S.E., Rubin,G.M. and Karpen,G.H.
TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun
assembly
JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002)
PUBMED 12537574
REFERENCE 8 (residues 1 to 2410)
AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
Rubin,G.M., Ashburner,M. and Celniker,S.E.
TITLE The transposable elements of the Drosophila melanogaster
euchromatin: a genomics perspective
JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002)
PUBMED 12537573
REFERENCE 9 (residues 1 to 2410)
AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
Rubin,G.M. and Lewis,S.E.
TITLE Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review
JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002)
PUBMED 12537572
REFERENCE 10 (residues 1 to 2410)
AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
Gibbs,R.A. and Rubin,G.M.
TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila
melanogaster euchromatic genome sequence
JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002)
PUBMED 12537568
REFERENCE 11 (residues 1 to 2410)
AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
TITLE The genome sequence of Drosophila melanogaster
JOURNAL Science 287 (5461), 2185-2195 (2000)
PUBMED 10731132
REFERENCE 12 (residues 1 to 2410)
AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
Smith,E., Yu,C. and Rubin,G.
CONSRTM Berkeley Drosophila Genome Project
TITLE Drosophila melanogaster release 4 sequence
JOURNAL Unpublished
REFERENCE 13 (residues 1 to 2410)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 14 (residues 1 to 2410)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 15 (residues 1 to 2410)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 16 (residues 1 to 2410)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 17 (residues 1 to 2410)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 18 (residues 1 to 2410)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 19 (residues 1 to 2410)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 20 (residues 1 to 2410)
AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
Park,S., Svirskas,R. and Karpen,G.
TITLE Direct Submission
JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
REMARK Direct Submission
REFERENCE 21 (residues 1 to 2410)
AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
Svirskas,R. and Rubin,G.
TITLE Direct Submission
JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
64-121, Berkeley, CA 94720, USA
REMARK Direct Submission
REFERENCE 22 (residues 1 to 2410)
AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
CONSRTM Drosophila Heterochromatin Genome Project
TITLE Direct Submission
JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE 23 (residues 1 to 2410)
AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
TITLE Direct Submission
JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
Rockville, MD 20850, USA
COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The
reference sequence is identical to AAF45684.
On Nov 6, 2002 this sequence version replaced NP_525040.1.
##Genome-Annotation-Data-START##
Annotation Provider :: FlyBase
Annotation Status :: Full annotation
Annotation Version :: Release 6.54
URL :: http://flybase.org
##Genome-Annotation-Data-END##
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..2410
/organism="Drosophila melanogaster"
/db_xref="taxon:7227"
/chromosome="X"
/genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
Protein 1..2410
/product="trithorax-related, isoform C"
/EC_number="2.1.1.364"
/EC_number="2.1.1.370"
/name="CG3848 gene product from transcript CG3848-RC"
/note="CG3848-PC; trr-PC; trithorax related;
Trithorax-related; Trx-related; trithorax-related protein"
/calculated_mol_wt=257276
Region 124..>299
/region_name="PHA03255"
/note="BDLF3; Provisional"
/db_xref="CDD:165513"
Region <602..>830
/region_name="PRK13914"
/note="invasion associated endopeptidase"
/db_xref="CDD:237555"
Region 1877..1981
/region_name="ePHD2_KMT2C_like"
/note="Extended PHD finger 2 found in histone-lysine
N-methyltransferase 2C (KMT2C) and 2D (KMT2D); cd15666"
/db_xref="CDD:277136"
Site order(1936,1945..1949,1955,1976)
/site_type="other"
/note="putative histone H3 binding site [polypeptide
binding]"
/db_xref="CDD:277136"
Region 2046..2097
/region_name="FYRN"
/note="F/Y-rich N-terminus; pfam05964"
/db_xref="CDD:428695"
Region 2105..2194
/region_name="FYRC"
/note="FY-rich domain, C-terminal region; smart00542"
/db_xref="CDD:197781"
Region 2257..2409
/region_name="SET_KMT2C_2D"
/note="SET domain (including post-SET domain) found in
histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D)
and similar proteins; cd19171"
/db_xref="CDD:380948"
Site order(2258..2260,2262..2263,2265,2293,2298..2299,
2301..2305,2307..2308,2310..2313,2323,2325..2327,2333,
2336..2338,2340..2342,2344,2356,2358,2361,2374,2383,
2385..2387)
/site_type="other"
/note="oligomer interface [polypeptide binding]"
/db_xref="CDD:380948"
Site order(2279..2282,2299,2310,2313,2323..2327,2333,
2344..2348,2356,2358,2383,2385..2387,2397..2400,2409)
/site_type="active"
/db_xref="CDD:380948"
Site order(2279..2282,2323..2324,2344..2348,2385,2397..2400,
2409)
/site_type="other"
/note="SAM binding site"
/db_xref="CDD:380948"
Site order(2299,2310,2313,2323,2325..2327,2333,2344,2356,2358,
2383,2385..2387)
/site_type="other"
/note="polypeptide substrate binding site [polypeptide
binding]"
/db_xref="CDD:380948"
Site order(2350,2398,2400,2405)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:380948"
Site 2385
/site_type="active"
/note="catalytic residue [active]"
/db_xref="CDD:380948"
CDS 1..2410
/gene="trr"
/locus_tag="Dmel_CG3848"
/gene_synonym="anon-2Bb; CG3848; Dmel\CG3848; dmll3/4;
EG:63B12.3; Trr; TRR"
/coded_by="NM_080301.3:176..7408"
/db_xref="FLYBASE:FBpp0070346"
/db_xref="GeneID:31149"
/db_xref="FLYBASE:FBgn0023518"
ORIGIN
1 mnipkvttsl gaaekakper vasvaaaafn avslqkrsgd dtatpaedpt rkkaktelll
61 gtgtaapslp akasstapqq llyqrsgqqa kaqvkaasep qdvetadgvw dardqqiivc
121 nfgsgtemga ikaedadkqt ftsftkkega sssassssst asvisiepsg sgqdhaensg
181 ksedldyvlm pasgadssts vgnstgtgtp agtpigatts tiilnanngt agvsgagttt
241 iltqksghtn ynifnttatg sqtptttlln rvnlhpkmkt qlmvnakkls evtqttakvs
301 ignktisvpl lkplmsasga ataggative skqllqpggq vttvmsaaqq sggqqvhphv
361 hshahhnftk likrgpknsg tivsfsglqi kpantkivat kvvskkmlql qqhqqqiqqq
421 qqlqqlqvts ggglapptgs ivtitttnps qtyamvqdsa tvgpaahsed dapaprkita
481 ysenlqkiln ksksqestgg peeftninsv vikpldkntl ncppsfnifk qqqhsqaaqs
541 qsisavgsga gtpvtftmas gnasdlatts tvsvsagtic inspmmgtrp iisiqnknis
601 lvlskttmaq qkpkmitttt lssqaalqmh haliqdssad kagssansgs atsgasmqlk
661 lttantptkl svslapdvvk leevgseska kllvkqeavv kdstgtptse eraeeigtpe
721 krlnanatmt ainqvqnqsa nqiqmatsts tasnpstpnp tvnatpmnnq rsaaednall
781 kqllqnnsss hslnqisits ahvgsasasa plsarkvinv rapsmgkvrs ledqlarpvi
841 ppvptatqaa gsssssgsva tstttttvas ggssqqvata satalpvsav aittpgvgge
901 akleqksdqp aaimqnqsqn qapppppppq qqqqqqlhqp qqlqpsphqv kqtvqivske
961 tsfisgpvaa ktlvteatsk paellppppy ematapisnv tisistkqaa pkelqmkpka
1021 vamslpmeqg deslpeqaep plhseqgata agvaphsggp lvsaqwtnnh leggvattki
1081 pfkpgepqkr klpmhpqlde kqiqqqaeip istslpttpt gqgtpdkvql isaiatyvkk
1141 sgvpneaqpi qnqsqgqvqm qaqmqatmqg hlsgqmsgqi sghaagqipa qmhlqvqhql
1201 hmavhpqqqq qqlhqnqpqn atiplpvtgq gavpipvptm eskagdqrkr rkrevqkprr
1261 tnlnagqagg alkdltgplp agamvqlagm ppgtqyiqga asgtghvits tgqgvtlggv
1321 gastgasssp mlkkrvrkfs kveedhdaft ekllthirqm qplqvlephl nrnfhfligs
1381 netsgggspa smssaasags ssagggklkg gsrgwplsrh legledcdgt vlgrygrvnl
1441 pgipslydse rfggsrglvg gsartrspsp aespgaekml pmssiqndfy dqefsthmer
1501 nprerlvrhi gavkdcnlet vdlvesegva awatlprltr ypglillngn srchgrmspv
1561 alpedpltmr fpvspllrsc geelrktqqm elgmgplgnn nnnnyqqknq nvilalpasa
1621 seniagvlrd lanllhlapa ltckiiedki gnkledqfmn qddekhvdfk rplsqvshgh
1681 lrkilngrrk lcrscgnvvh atglrvprhs vpaleeqlpr laqlmdmlpr ksvpppfvyf
1741 cdracfarfk wngkdgqaea aslllqpagg savkssngds pgsfcassta paemvvkqep
1801 ededektpsv pgnptnipaq rkcivkcfsa dcfttdsaps gleldgtaga gtgagpvnnt
1861 vwetetsglq ledtrqcvfc nqrgdgqadg psrllnfdvd kwvhlncalw sngvyetvsg
1921 almnfqtalq aglsqacsac hqpgatikcf ksrcnslyhl pcaireecvf yknksvhcsv
1981 hghahagitm gagagattga glggsvadne lsslvvhrrv fvdrdenrqv atvmhysels
2041 nllrvgnmtf lnvgqllphq leafhtphyi ypigykvsry ywcvrrpnrr cryicsiaea
2101 gckpefriqv qdagdkeper efrgsspsav wqqilqpitr lrkvhkwlql fpqhisgedl
2161 fgltepaivr ileslpgiet ltdyrfkygr npllefplai npsgaartep kqrqllvwrk
2221 phtqrtagsc stqrmansaa iagevacpys kqfvhskssq ykkmkqewrn nvylarskiq
2281 glglyaardi ekhtmiieyi gevirtevse irekqyeskn rgiymfrlde drvvdatlsg
2341 glaryinhsc npncvteive vdrdvriiif akrkiyrgee lsydykfdie deshkipcac
2401 gapncrkwmn
//
