LOCUS NP_644815 85 aa linear PRI 28-APR-2025
DEFINITION anaphase-promoting complex subunit CDC26 [Homo sapiens].
ACCESSION NP_644815
VERSION NP_644815.1
DBSOURCE REFSEQ: accession NM_139286.4
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 85)
AUTHORS Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
and Leonetti,M.D.
TITLE OpenCell: Endogenous tagging for the cartography of human cellular
organization
JOURNAL Science 375 (6585), eabi6983 (2022)
PUBMED 35271311
REFERENCE 2 (residues 1 to 85)
AUTHORS Wu,H., Zhang,X., Shen,Q., Liu,Y., Gao,Y., Wang,G., Lv,M., Hua,R.,
Xu,Y., Zhou,P., Wei,Z., Tao,F., He,X., Cao,Y. and Liu,M.
TITLE A homozygous loss-of-function mutation in FBXO43 causes human
non-obstructive azoospermia
JOURNAL Clin Genet 101 (1), 55-64 (2022)
PUBMED 34595750
REFERENCE 3 (residues 1 to 85)
AUTHORS Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
Harper,J.W. and Gygi,S.P.
TITLE Dual proteome-scale networks reveal cell-specific remodeling of the
human interactome
JOURNAL Cell 184 (11), 3022-3040 (2021)
PUBMED 33961781
REFERENCE 4 (residues 1 to 85)
AUTHORS Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
TITLE Interactome Mapping Provides a Network of Neurodegenerative Disease
Proteins and Uncovers Widespread Protein Aggregation in Affected
Brains
JOURNAL Cell Rep 32 (7), 108050 (2020)
PUBMED 32814053
REFERENCE 5 (residues 1 to 85)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 6 (residues 1 to 85)
AUTHORS Geley,S., Kramer,E., Gieffers,C., Gannon,J., Peters,J.M. and
Hunt,T.
TITLE Anaphase-promoting complex/cyclosome-dependent proteolysis of human
cyclin A starts at the beginning of mitosis and is not subject to
the spindle assembly checkpoint
JOURNAL J Cell Biol 153 (1), 137-148 (2001)
PUBMED 11285280
REFERENCE 7 (residues 1 to 85)
AUTHORS Gmachl,M., Gieffers,C., Podtelejnikov,A.V., Mann,M. and Peters,J.M.
TITLE The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are
sufficient to ubiquitinate substrates of the anaphase-promoting
complex
JOURNAL Proc Natl Acad Sci U S A 97 (16), 8973-8978 (2000)
PUBMED 10922056
REFERENCE 8 (residues 1 to 85)
AUTHORS Kramer,E.R., Scheuringer,N., Podtelejnikov,A.V., Mann,M. and
Peters,J.M.
TITLE Mitotic regulation of the APC activator proteins CDC20 and CDH1
JOURNAL Mol Biol Cell 11 (5), 1555-1569 (2000)
PUBMED 10793135
REFERENCE 9 (residues 1 to 85)
AUTHORS Lukas,C., Sorensen,C.S., Kramer,E., Santoni-Rugiu,E., Lindeneg,C.,
Peters,J.M., Bartek,J. and Lukas,J.
TITLE Accumulation of cyclin B1 requires E2F and cyclin-A-dependent
rearrangement of the anaphase-promoting complex
JOURNAL Nature 401 (6755), 815-818 (1999)
PUBMED 10548110
REFERENCE 10 (residues 1 to 85)
AUTHORS Zachariae,W., Shin,T.H., Galova,M., Obermaier,B. and Nasmyth,K.
TITLE Identification of subunits of the anaphase-promoting complex of
Saccharomyces cerevisiae
JOURNAL Science 274 (5290), 1201-1204 (1996)
PUBMED 8895471
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BF244254.1, BC042534.1,
CA446805.1 and AL449305.4.
Summary: The protein encoded by this gene is highly similar to
Saccharomyces cerevisiae Cdc26, a component of cell cycle
anaphase-promoting complex (APC). APC is composed of a group of
highly conserved proteins and functions as a cell cycle-regulated
ubiquitin-protein ligase. APC thus is responsible for the cell
cycle regulated proteolysis of various proteins. [provided by
RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC066300.1, BU661772.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA2142348,
SAMEA2142363 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000374206.4/ ENSP00000363322.3
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..85
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q32"
Protein 1..85
/product="anaphase-promoting complex subunit CDC26"
/note="CDC26 subunit of anaphase promoting complex; cell
division cycle protein 26 homolog; anaphase-promoting
complex subunit 12; cell division cycle 26 homolog"
/calculated_mol_wt=9646
Region 1..>34
/region_name="ANAPC_CDC26"
/note="Anaphase-promoting complex APC subunit CDC26;
pfam10471"
/db_xref="CDD:402205"
Region 30..85
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q8NHZ8.1)"
Site 42
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:18669648,
ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
propagated from UniProtKB/Swiss-Prot (Q8NHZ8.1)"
Site 82
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:20068231,
ECO:0007744|PubMed:21406692; propagated from
UniProtKB/Swiss-Prot (Q8NHZ8.1)"
CDS 1..85
/gene="CDC26"
/gene_synonym="ANAPC12; APC12; C9orf17"
/coded_by="NM_139286.4:343..600"
/db_xref="CCDS:CCDS6790.1"
/db_xref="GeneID:246184"
/db_xref="HGNC:HGNC:17839"
/db_xref="MIM:614533"
ORIGIN
1 mlrrkptrle lklddieefe nirkdletrk kqkedvevvg gsdgegaigl ssdpksreqm
61 indrigykpq pkpnnrssqf gslef
//
