Database: RefSeq
Entry: NP_644815
LinkDB: NP_644815
Original site: NP_644815 
LOCUS       NP_644815                 85 aa            linear   PRI 24-JUL-2020
DEFINITION  anaphase-promoting complex subunit CDC26 [Homo sapiens].
VERSION     NP_644815.1
DBSOURCE    REFSEQ: accession NM_139286.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 85)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 85)
  AUTHORS   Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
            JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
            Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 85)
  AUTHORS   Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA,
            Weisswange I, Mansfeld J, Buchholz F, Hyman AA and Mann M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   4  (residues 1 to 85)
  AUTHORS   Wang J, Huo K, Ma L, Tang L, Li D, Huang X, Yuan Y, Li C, Wang W,
            Guan W, Chen H, Jin C, Wei J, Zhang W, Yang Y, Liu Q, Zhou Y, Zhang
            C, Wu Z, Xu W, Zhang Y, Liu T, Yu D, Zhang Y, Chen L, Zhu D, Zhong
            X, Kang L, Gan X, Yu X, Ma Q, Yan J, Zhou L, Liu Z, Zhu Y, Zhou T,
            He F and Yang X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol. Syst. Biol. 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12 ):965. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 85)
  AUTHORS   Hutchins JR, Toyoda Y, Hegemann B, Poser I, Heriche JK, Sykora MM,
            Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C,
            Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM,
            Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S,
            Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F,
            Mechtler K, Hyman AA and Peters JM.
  TITLE     Systematic analysis of human protein complexes identifies
            chromosome segregation proteins
  JOURNAL   Science 328 (5978), 593-599 (2010)
   PUBMED   20360068
REFERENCE   6  (residues 1 to 85)
  AUTHORS   Geley S, Kramer E, Gieffers C, Gannon J, Peters JM and Hunt T.
  TITLE     Anaphase-promoting complex/cyclosome-dependent proteolysis of human
            cyclin A starts at the beginning of mitosis and is not subject to
            the spindle assembly checkpoint
  JOURNAL   J. Cell Biol. 153 (1), 137-148 (2001)
   PUBMED   11285280
REFERENCE   7  (residues 1 to 85)
  AUTHORS   Gmachl M, Gieffers C, Podtelejnikov AV, Mann M and Peters JM.
  TITLE     The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are
            sufficient to ubiquitinate substrates of the anaphase-promoting
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 97 (16), 8973-8978 (2000)
   PUBMED   10922056
REFERENCE   8  (residues 1 to 85)
  AUTHORS   Kramer ER, Scheuringer N, Podtelejnikov AV, Mann M and Peters JM.
  TITLE     Mitotic regulation of the APC activator proteins CDC20 and CDH1
  JOURNAL   Mol. Biol. Cell 11 (5), 1555-1569 (2000)
   PUBMED   10793135
REFERENCE   9  (residues 1 to 85)
  AUTHORS   Lukas C, Sorensen CS, Kramer E, Santoni-Rugiu E, Lindeneg C, Peters
            JM, Bartek J and Lukas J.
  TITLE     Accumulation of cyclin B1 requires E2F and cyclin-A-dependent
            rearrangement of the anaphase-promoting complex
  JOURNAL   Nature 401 (6755), 815-818 (1999)
   PUBMED   10548110
REFERENCE   10 (residues 1 to 85)
  AUTHORS   Zachariae W, Shin TH, Galova M, Obermaier B and Nasmyth K.
  TITLE     Identification of subunits of the anaphase-promoting complex of
            Saccharomyces cerevisiae
  JOURNAL   Science 274 (5290), 1201-1204 (1996)
   PUBMED   8895471
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF244254.1, BC042534.1,
            CA446805.1 and AL449305.4.
            Summary: The protein encoded by this gene is highly similar to
            Saccharomyces cerevisiae Cdc26, a component of cell cycle
            anaphase-promoting complex (APC). APC is composed of a group of
            highly conserved proteins and functions as a cell cycle-regulated
            ubiquitin-protein ligase. APC thus is responsible for the cell
            cycle regulated proteolysis of various proteins. [provided by
            RefSeq, Jul 2008].
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            Transcript exon combination :: SRR5189655.161982.1,
                                           SRR5189655.40131.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2142348, SAMEA2142363
            MANE Ensembl match     :: ENST00000374206.4/ ENSP00000363322.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
FEATURES             Location/Qualifiers
     source          1..85
                     /organism="Homo sapiens"
     Protein         1..85
                     /product="anaphase-promoting complex subunit CDC26"
                     /note="CDC26 subunit of anaphase promoting complex; cell
                     division cycle protein 26 homolog; anaphase-promoting
                     complex subunit 12; cell division cycle 26 homolog"
     Region          1..>34
                     /note="Anaphase-promoting complex APC subunit CDC26;
     Site            42
                     ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q8NHZ8.1)"
     Site            82
                     ECO:0000244|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q8NHZ8.1)"
     CDS             1..85
                     /gene_synonym="ANAPC12; APC12; C9orf17"
        1 mlrrkptrle lklddieefe nirkdletrk kqkedvevvg gsdgegaigl ssdpksreqm
       61 indrigykpq pkpnnrssqf gslef
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