LOCUS NP_766054 1219 aa linear ROD 07-AUG-2023
DEFINITION A disintegrin and metalloproteinase with thrombospondin motifs 18
isoform a precursor [Mus musculus].
ACCESSION NP_766054
VERSION NP_766054.2
DBSOURCE REFSEQ: accession NM_172466.4
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 1219)
AUTHORS Wang L, Sun M, Zhang Q, Dang S and Zhang W.
TITLE ADAMTS18 regulates early branching morphogenesis of lacrimal gland
and has a significant association with the risk of dry eye in mice
JOURNAL Exp Eye Res 218, 109020 (2022)
PUBMED 35240198
REMARK GeneRIF: ADAMTS18 regulates early branching morphogenesis of
lacrimal gland and has a significant association with the risk of
dry eye in mice.
REFERENCE 2 (residues 1 to 1219)
AUTHORS Yang N, Zhang Q, Ye S, Lu T, Sun M, Wang L, Wang M, Pan YH, Dang S
and Zhang W.
TITLE Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult
Mice
JOURNAL J Dent Res 101 (2), 226-234 (2022)
PUBMED 34323105
REMARK GeneRIF: Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in
Adult Mice.
REFERENCE 3 (residues 1 to 1219)
AUTHORS Lin X, Wu T, Wang L, Dang S and Zhang W.
TITLE ADAMTS18 deficiency leads to preputial gland hypoplasia and
fibrosis in male mice
JOURNAL Reprod Biol 21 (3), 100542 (2021)
PUBMED 34388417
REMARK GeneRIF: ADAMTS18 deficiency leads to preputial gland hypoplasia
and fibrosis in male mice.
REFERENCE 4 (residues 1 to 1219)
AUTHORS Lin X, Wang C, Zhang Q, Pan YH, Dang S and Zhang W.
TITLE ADAMTS18 regulates vaginal opening through influencing the fusion
of Mullerian duct and apoptosis of vaginal epithelial cells in mice
JOURNAL Reprod Biol 21 (3), 100537 (2021)
PUBMED 34271244
REMARK GeneRIF: ADAMTS18 regulates vaginal opening through influencing the
fusion of Mullerian duct and apoptosis of vaginal epithelial cells
in mice.
REFERENCE 5 (residues 1 to 1219)
AUTHORS Ye S, Yang N, Lu T, Wu T, Wang L, Pan YH, Cao X, Yuan X, Wisniewski
T, Dang S and Zhang W.
TITLE Adamts18 modulates the development of the aortic arch and common
carotid artery
JOURNAL iScience 24 (6), 102672 (2021)
PUBMED 34189436
REMARK Publication Status: Online-Only
REFERENCE 6 (residues 1 to 1219)
AUTHORS Aldahmesh MA, Khan AO, Mohamed JY, Alkuraya H, Ahmed H, Bobis S,
Al-Mesfer S and Alkuraya FS.
TITLE Identification of ADAMTS18 as a gene mutated in Knobloch syndrome
JOURNAL J Med Genet 48 (9), 597-601 (2011)
PUBMED 21862674
REMARK GeneRIF: Adamts18 is expressed in the lens and retina in the
developing murine eye.
REFERENCE 7 (residues 1 to 1219)
AUTHORS Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M,
Haltiwanger RS and Holdener BC.
TITLE O-fucosylation of thrombospondin type 1 repeats restricts
epithelial to mesenchymal transition (EMT) and maintains epiblast
pluripotency during mouse gastrulation
JOURNAL Dev Biol 346 (1), 25-38 (2010)
PUBMED 20637190
REFERENCE 8 (residues 1 to 1219)
AUTHORS Li Z, Nardi MA, Li YS, Zhang W, Pan R, Dang S, Yee H, Quartermain
D, Jonas S and Karpatkin S.
TITLE C-terminal ADAMTS-18 fragment induces oxidative platelet
fragmentation, dissolves platelet aggregates, and protects against
carotid artery occlusion and cerebral stroke
JOURNAL Blood 113 (24), 6051-6060 (2009)
PUBMED 19218546
REFERENCE 9 (residues 1 to 1219)
AUTHORS Stankunas K, Hang CT, Tsun ZY, Chen H, Lee NV, Wu JI, Shang C,
Bayle JH, Shou W, Iruela-Arispe ML and Chang CP.
TITLE Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment
for myocardial morphogenesis
JOURNAL Dev Cell 14 (2), 298-311 (2008)
PUBMED 18267097
REFERENCE 10 (residues 1 to 1219)
AUTHORS Holmberg M, Leonardsson G and Ny T.
TITLE The species-specific differences in the cAMP regulation of the
tissue-type plasminogen activator gene between rat, mouse and human
is caused by a one-nucleotide substitution in the cAMP-responsive
element of the promoters
JOURNAL Eur J Biochem 231 (2), 466-474 (1995)
PUBMED 7543410
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC108856.20 and AC125463.4.
On Jan 10, 2007 this sequence version replaced NP_766054.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK140876.1, BC094674.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMN00849374,
SAMN00849375 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..1219
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="8"
/map="8 59.65 cM"
Protein 1..1219
/product="A disintegrin and metalloproteinase with
thrombospondin motifs 18 isoform a precursor"
/note="a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 18; a disintegrin
and metalloproteinase with thrombospondin motifs 18; a
disintegrin-like and metallopeptidase (reprolysin type)
with thrombospondin type 1 motif, 18"
/calculated_mol_wt=130601
sig_peptide 1..47
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=4662
Region 65..203
/region_name="Pep_M12B_propep"
/note="Reprolysin family propeptide; pfam01562"
/db_xref="CDD:426325"
Site 151
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q4VC17.2)"
Site 190
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q4VC17.2)"
Region 217..248
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q4VC17.2)"
mat_peptide 285..1219
/product="A disintegrin and metalloproteinase with
thrombospondin motifs 18. /id=PRO_0000042164"
/note="propagated from UniProtKB/Swiss-Prot (Q4VC17.2)"
/calculated_mol_wt=104028
Region 293..494
/region_name="ZnMc_ADAMTS_like"
/note="Zinc-dependent metalloprotease, ADAMTS_like
subgroup. ADAMs (A Disintegrin And Metalloprotease) are
glycoproteins, which play roles in cell signaling, cell
fusion, and cell-cell interactions. This particular
subfamily represents domain architectures that...;
cd04273"
/db_xref="CDD:239801"
Site order(436..437,440,446)
/site_type="active"
/db_xref="CDD:239801"
Region 511..578
/region_name="ADAM_CR_2"
/note="ADAM cysteine-rich domain; pfam17771"
/db_xref="CDD:436031"
Region 592..644
/region_name="TSP1"
/note="Thrombospondin type 1 repeats; smart00209"
/db_xref="CDD:214559"
Region 648..748
/region_name="ADAM_CR_3"
/note="ADAM cysteine-rich domain; pfam19236"
/db_xref="CDD:437068"
Site 745
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q4VC17.2)"
Region 750..861
/region_name="ADAM_spacer1"
/note="ADAM-TS Spacer 1; pfam05986"
/db_xref="CDD:428708"
Site 838
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q4VC17.2)"
Site 865
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q4VC17.2)"
Region 883..931
/region_name="TSP1_ADAMTS"
/note="Thrombospondin type 1 domain; pfam19030"
/db_xref="CDD:408800"
Site 909
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q4VC17.2)"
Region 935..991
/region_name="TSP1_ADAMTS"
/note="Thrombospondin type 1 domain; pfam19030"
/db_xref="CDD:408800"
Region 995..1048
/region_name="TSP1_ADAMTS"
/note="Thrombospondin type 1 domain; pfam19030"
/db_xref="CDD:408800"
Region 1056..1115
/region_name="TSP1_ADAMTS"
/note="Thrombospondin type 1 domain; pfam19030"
/db_xref="CDD:408800"
Region 1125..1171
/region_name="TSP1_ADAMTS"
/note="Thrombospondin type 1 domain; pfam19030"
/db_xref="CDD:408800"
Region 1186..1216
/region_name="PLAC"
/note="PLAC (protease and lacunin) domain; pfam08686"
/db_xref="CDD:430154"
CDS 1..1219
/gene="Adamts18"
/gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
/coded_by="NM_172466.4:268..3927"
/note="isoform a precursor is encoded by transcript
variant 1"
/db_xref="CCDS:CCDS40485.1"
/db_xref="GeneID:208936"
/db_xref="MGI:MGI:2442600"
ORIGIN
1 mecallclca lraagpgppw gpaglgrlak alqlccfcca svavalasds gssggsglnd
61 dyvfvvpvev dsggsyishd ilhhrkrrsa hgasnslhyr vsafgqdlhl elkpsailss
121 hfrvqvlgkd gasetrepev pqclyqgfir ndssssvavs tcaglsglir trdneflisp
181 lpqllaqehn ysspaghhph vlykrtaekr vrwyqdypgs qrtypghsps htppasqsqe
241 peyshrrwqk rhfcgrrkky apkppaeday lrfdeyggtg rprrsagksq nglnvetlvv
301 adakmvekhg kddvttyilt vmnmvsslfk dgtigsdini vvvslillee epegllinhh
361 adqslnsfcq wqsalvgkng krhdhaillt gfdicswkne pcdtlgfapi sgmcskyrsc
421 tinedtglgl aftiahesgh nfgmvhdgeg npcrkaegni msptltgnng vfswsscsrq
481 ylkkflstpq agclvdepkq tgqykypdkl pgqiydadmq ckwqfgakak lcslgvmkdi
541 ckslwchrvg hrcetkfmpa aegtacglsm wcrqgqcvkl gelgprpihg qwsawskwse
601 csrtcgggvk fqerhcsnpk pqyggkycpg ssriyklcni npcpensldf raqqcaeynn
661 kpfrgwlyrw kpytkveeed rcklyckaen fefffamsgk vkdgtpcsph rndvcidgic
721 elvgcdhelg skavsdacgv ckgdnstckf ykglylsqhk aneyypvvti pagarsieiq
781 elqlsssyla vrslsqkyyl tggwsidwpg dftfagttfe yqrsfnrper lyapgptnet
841 lvfeiltqgk npgiawkyal pkvmnvtqpa tkryhhtwrt vqsdcsvtcg ggyisikaic
901 lrdqhtqvns sfcsvrtkpa tepkicnafs cpaywlpgew sacskscagg qqsrkircvq
961 kkpfqkeeav lhslcpvstp tqvqvcnsha cppewspspw sqcsktcgrg vrrrevlcks
1021 paaetlpesl csssprpeaq egcvlgrcpk nnrlqwiasa wsecsatcgl gvrkrelkcv
1081 ektlqgklit fperrcrnik kpsleleeac nqrtcpvysm avaswysspw qqctvtcggg
1141 vqtrsvhcmq qgrpssscll hqkppvlrac ntnfcpapek kddpscvdff swchlvpqhg
1201 vcnhkfygkq ccrsctrks
//
