GenomeNet

Database: RefSeq
Entry: NP_776795
LinkDB: NP_776795
Original site: NP_776795 
LOCUS       NP_776795               2664 aa            linear   MAM 16-FEB-2019
DEFINITION  inositol 1,4,5-trisphosphate receptor type 3 [Bos taurus].
ACCESSION   NP_776795 XP_606495 XP_617881
VERSION     NP_776795.1
DBSOURCE    REFSEQ: accession NM_174370.3
KEYWORDS    RefSeq.
SOURCE      Bos taurus (cattle)
  ORGANISM  Bos taurus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
            Pecora; Bovidae; Bovinae; Bos.
REFERENCE   1  (residues 1 to 2664)
  AUTHORS   Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D,
            Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G,
            Roberts M, Subramanian P, Yorke JA and Salzberg SL.
  TITLE     A whole-genome assembly of the domestic cow, Bos taurus
  JOURNAL   Genome Biol. 10 (4), R42 (2009)
   PUBMED   19393038
REFERENCE   2  (residues 1 to 2664)
  AUTHORS   Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling
            WM, Wiedmann RT, Van Tassell CP and Smith TP.
  TITLE     Characterization of 954 bovine full-CDS cDNA sequences
  JOURNAL   BMC Genomics 6, 166 (2005)
   PUBMED   16305752
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2664)
  AUTHORS   Steffl M, Schweiger M and Amselgruber WM.
  TITLE     Colocalization of chromogranin A and inositol 1,4,5-trisphosphate
            receptor in ciliated cells of the bovine oviduct
  JOURNAL   Ann. Anat. 185 (2), 103-108 (2003)
   PUBMED   12725433
  REMARK    GeneRIF: role in cillary movement, coupled with chromogranin A
REFERENCE   4  (residues 1 to 2664)
  AUTHORS   Yoo SH, Oh YS, Kang MK, Huh YH, So SH, Park HS and Park HY.
  TITLE     Localization of three types of the inositol 1,4,5-trisphosphate
            receptor/Ca(2+) channel in the secretory granules and coupling with
            the Ca(2+) storage proteins chromogranins A and B
  JOURNAL   J. Biol. Chem. 276 (49), 45806-45812 (2001)
   PUBMED   11584008
REFERENCE   5  (residues 1 to 2664)
  AUTHORS   Smith TP, Grosse WM, Freking BA, Roberts AJ, Stone RT, Casas E,
            Wray JE, White J, Cho J, Fahrenkrug SC, Bennett GL, Heaton MP,
            Laegreid WW, Rohrer GA, Chitko-McKown CG, Pertea G, Holt I,
            Karamycheva S, Liang F, Quackenbush J and Keele JW.
  TITLE     Sequence evaluation of four pooled-tissue normalized bovine cDNA
            libraries and construction of a gene index for cattle
  JOURNAL   Genome Res. 11 (4), 626-630 (2001)
   PUBMED   11282978
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF402601.1.
            On or before Mar 29, 2005 this sequence version replaced
            XP_606495.1, XP_617881.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF402601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03145413, SAMN03145415
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2664
                     /organism="Bos taurus"
                     /db_xref="taxon:9913"
                     /chromosome="23"
                     /map="23"
     Protein         1..2664
                     /product="inositol 1,4,5-trisphosphate receptor type 3"
                     /note="inositol 1,4,5-triphosphate receptor, type 3;
                     insP3R3; type 3 InsP3 receptor; IP3 receptor; type 3
                     inositol 1,4,5-trisphosphate receptor; IP3R 3; killer cell
                     lectin-like receptor subfamily G member 2"
                     /calculated_mol_wt=302911
     Region          3..226
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:285871"
     Region          232..288
                     /region_name="MIR"
                     /note="Domain in ryanodine and inositol trisphosphate
                     receptors and protein O-mannosyltransferases; smart00472"
                     /db_xref="CDD:197746"
     Region          234..432
                     /region_name="MIR"
                     /note="MIR domain; pfam02815"
                     /db_xref="CDD:280906"
     Region          266..270
                     /region_name="Inositol 1,4,5-trisphosphate binding.
                     {ECO:0000250}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Region          295..>348
                     /region_name="MIR"
                     /note="Domain in ryanodine and inositol trisphosphate
                     receptors and protein O-mannosyltransferases; smart00472"
                     /db_xref="CDD:197746"
     Region          475..665
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:279676"
     Region          507..510
                     /region_name="Inositol 1,4,5-trisphosphate binding.
                     {ECO:0000250}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Region          567..569
                     /region_name="Inositol 1,4,5-trisphosphate binding.
                     {ECO:0000250}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Site            909
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:Q14573};
                     propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Site            927
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:Q14573};
                     propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Site            1806
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:Q14573};
                     propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Site            1825
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:Q14573};
                     propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Site            1827
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:Q14573};
                     propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Region          1862..1967
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:285630"
     Region          <2194..2325
                     /region_name="ABC2_membrane_4"
                     /note="ABC-2 family transporter protein; pfam12730"
                     /db_xref="CDD:289500"
     Site            2228..2248
                     /site_type="transmembrane region"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Site            2257..2277
                     /site_type="transmembrane region"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Region          2267..2521
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:278921"
     Site            2287..2304
                     /site_type="transmembrane region"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Site            2319..2339
                     /site_type="transmembrane region"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Site            2362..2382
                     /site_type="transmembrane region"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Site            2490..2510
                     /site_type="transmembrane region"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Site            2602
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:Q14573};
                     propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     Site            2663
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:Q14573};
                     propagated from UniProtKB/Swiss-Prot (Q8WN95.1)"
     CDS             1..2664
                     /gene="ITPR3"
                     /coded_by="NM_174370.3:14..8008"
                     /db_xref="BGD:BT13799"
                     /db_xref="GeneID:281879"
                     /db_xref="VGNC:VGNC:30348"
ORIGIN      
        1 msemssflhi gdivslyaeg svngfistlg lvddrcvvep aagdldnppk kfrdclfkvc
       61 pmnrysaqkq ywkakqtkqd kekiadvvll qklqhaaqme qkqndtenkk vhgdvvkygs
      121 viqllhmksn kyltvnkrlp alleknamrv tldatgnegs wlfiqpfwkl rsngdnvvvg
      181 dkvilnpvna gqplhasnye lsdnagckev nsvncntswk inlfmqfrdh leevlkggdv
      241 vrlfhaeqek fltcdeyrgk lqvflrttlr qsatsatssn alwevevvhh dpcrggaghw
      301 nglyrfkhla tgnylaaeen psykgdasdp kaagtgaqgr tgrrnageki kyrlvavphg
      361 ndiaslfeld pttlqktdsf vprnsyvrlr hlctntwiqs tnvpidveee rpirlmlgtc
      421 ptkedkeafa ivsvpvseir dldfandass mlasaveklh egfisqndrr fviqlledlv
      481 ffvsdvpnng qnvldimvtk pnrerqklmr eqnilkqifg ilkapfrdkg gegplvrlee
      541 lsdqknapyq hmfrlcyrvl rhsqedyrkn qehiakqfgm mqsqigydil aedtitallh
      601 nnrkllekhi tktevetfvs lvrknreprf ldylsdlcvs nhiaipvtqe lickcvldpk
      661 nsdiliqtel rpvkemaqsh eylsieysee evwltwtdkn nehheksvrq laqearagna
      721 hdenvlsyyr yqlklfarmc ldrqylaide isqqlgvdli flcmademlp fdlrasfchl
      781 mlhvhvdrdp qelvtpvkfa rlwteiptai tikdydsnln asrddkknkf astmefvedy
      841 lnnvvseavp faneeknklt fevvslahnl iyfgfysfse llrltrtllg iidcvqayed
      901 pggknvrrst qgvghmmstm vlnrkqsvfg gpslpagaga pepldgskfe enedivvmet
      961 klkileilqf ilnvrldyri syllsvfkke fvevfpmqds gadgtapafd sttanmnldr
     1021 igeqaeamfg vgktssmlev ddeggrmllr vlihltmhdy aplvsgalql lfkhfsqrqe
     1081 vmhtfkqvql lisaqdveny kvikseldrl rtmvekselw vdkkgaskge egeagpakdk
     1141 kerptdeegf lhppgeksse nyqivkgile rlnkmcgvge qmrkkqqrll knmdahkvml
     1201 dllqipydkg dakmmeilry thqflqkfca gnpgnqallh khlhlfltpg lleaetmqhi
     1261 flnnyqlcse igepvlqhfv hllathghhv qyldflhtvi kaegkyvkkc qdmimtepan
     1321 agddvvvfyn dkaslahlld mmkaardgve dhsplmyhis lvdllaacae gknvyteikc
     1381 tsllpledvv svvthedcit evkmayvnfv nhcyvdteve mkeiytsnhi wtlfenftld
     1441 marvcskrek rladpaleky vltvvldtis affsspfsen stslqthqti vvqllqstmr
     1501 llecpwlqqq hkgsveacir tlamvakgra islpmdldah issllssgas cvaaaqrnas
     1561 nyktatrafp rvmptanqwd ykniieklqd iitaleerlr plvqaelsvl vdvlhwpell
     1621 flegsdayqr cesggflskl iqhtkdlmes eeklcvkvlr tlqqmllkkt kygdrgnqlr
     1681 kmllqnylqn rksssrgdlp dpmgtgldqd wsaiaatqcr ldkegatklv cdlitstkne
     1741 kifqesigla irlldggnte iqksfynlmt sdkkserffk vlhdrmkraq qetkstvavn
     1801 msdlgsqpre dreqadptsk grvasfsmps sssryalgps lrrghevger vqsnemgtsv
     1861 limqpilrfl qllcenhnrd lqnflrcqnn ktnynlvcet lqfldimcgs ttgglgllgl
     1921 yinednvglv iqtletltey cqgpchenqt civthesngi diitalilnd isplckyrmd
     1981 lvlqlkdnas klllalmesr hdsenaeril islrpqelvd vikkaylqee erensdvspr
     2041 evghniyila lqlsrhnkql qhllkpvkri qeeeaegiss mlslnnkqlt qmlkssapvq
     2101 eqeedplayy enhtsqieiv rqdrsmeqiv fpvpgicqfl teetkhrlft tteqdeqgsk
     2161 vsdlfdqpsf lhnemewqrk lrsmpliywf srrmtlwgsi sfnlavfini iiaffypyve
     2221 gastgvlgsp lisllfwili cfsiaalftk rysvrpliva lilrsiyylg igptlnilga
     2281 lnltnkivfv vsfvgnrgtf irgykamvmd meflyhvgyi ltsvlglfah elfysillfd
     2341 liyreetlfn viksvtrngr silltallal ilvylfsivg flflkddfil evdrlpgnhs
     2401 ranplgmphg aatfvntcsg dnvdcvsgvs vpevlaedee pdsteracdt llmcivtvmn
     2461 hglrngggvg dilrkpskde slfparvvyd llfffiviii vlnlifgvii dtfadlrsek
     2521 qkkeeilktt cficglerdk fdnktvsfee hikfehnmwn ylyfivlvrv knktdytgpe
     2581 syvaqmiknk nldwfprmra mslvssegeg eqneirilqd klsatmklvs hltaqlselk
     2641 eqmteqrkrr qrlgfvdvqn cmsr
//
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