LOCUS       NP_777579                263 aa            linear   PRI 29-DEC-2022
DEFINITION  rho GTPase-activating protein 27 isoform c [Homo sapiens].
ACCESSION   NP_777579 XP_371057
VERSION     NP_777579.2
DBSOURCE    REFSEQ: accession NM_174919.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 263)
  AUTHORS   Katoh Y and Katoh M.
  TITLE     Identification and characterization of ARHGAP27 gene in silico
  JOURNAL   Int J Mol Med 14 (5), 943-947 (2004)
   PUBMED   15492870
REFERENCE   2  (residues 1 to 263)
  AUTHORS   Sakakibara T, Nemoto Y, Nukiwa T and Takeshima H.
  TITLE     Identification and characterization of a novel Rho GTPase
            activating protein implicated in receptor-mediated endocytosis
  JOURNAL   FEBS Lett 566 (1-3), 294-300 (2004)
   PUBMED   15147912
REFERENCE   3  (residues 1 to 263)
  AUTHORS   Peck J, Douglas G 4th, Wu CH and Burbelo PD.
  TITLE     Human RhoGAP domain-containing proteins: structure, function and
            evolutionary relationships
  JOURNAL   FEBS Lett 528 (1-3), 27-34 (2002)
   PUBMED   12297274
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091132.16.
            
            On Apr 15, 2009 this sequence version replaced NP_777579.1.
            
            Summary: This gene encodes a member of a large family of proteins
            that activate Rho-type guanosine triphosphate (GTP) metabolizing
            enzymes. The encoded protein may pay a role in clathrin-mediated
            endocytosis. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Aug 2013].
            
            Transcript Variant: This variant (3) is a short variant at the 5'
            end of a much longer ARHGAP27 gene, and differs in the UTRs and CDS
            compared to variant 4. The encoded isoform (c) is shorter than
            isoform d.
            
            CCDS Note: This CCDS represents a short variant at the 5' end of a
            much longer ARHGAP27 gene. The protein includes an SH3 domain.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067345.1, AK290650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..263
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     Protein         1..263
                     /product="rho GTPase-activating protein 27 isoform c"
                     /note="SH3 domain containing 20; rho GTPase-activating
                     protein 27; CIN85-associated multi-domain-containing Rho
                     GTPase-activating protein 1; rho-type GTPase-activating
                     protein 27; SH3 domain-containing protein 20"
                     /calculated_mol_wt=28061
     Region          10..66
                     /region_name="SH3_ARHGAP27"
                     /note="Src Homology 3 domain of Rho GTPase-activating
                     protein 27; cd12069"
                     /db_xref="CDD:213002"
     Site            order(15,17,20,26,44..45,60,62..63)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:213002"
     Region          104..132
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZUM4.3)"
     Site            156
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6TLK4; propagated from
                     UniProtKB/Swiss-Prot (Q6ZUM4.3)"
     Site            216
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A2AB59; propagated from
                     UniProtKB/Swiss-Prot (Q6ZUM4.3)"
     CDS             1..263
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /coded_by="NM_174919.4:404..1195"
                     /note="isoform c is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS32670.1"
                     /db_xref="GeneID:201176"
                     /db_xref="HGNC:HGNC:31813"
                     /db_xref="MIM:610591"
ORIGIN      
        1 maadvvgdvy vlvehpfeyt gkdgrrvair pneryrllrr stehwwhvrr epggrpfylp
       61 aqyvrelpal gnpaaaappg phpspaapep laydyrfvsa aatagpdgap eesggrassl
      121 cgpaqrgaat qrsslapglp aclylrpaap vrpaqslndl acaavsppag llgssgsfka
      181 csvagswvcp rplarsdsen vyeviqdlhv pppeesaeqv ppralgrggg wrardrarte
      241 pgrketrsaq rrarrpplse dfg
//