GenomeNet

Database: RefSeq
Entry: NP_803172
LinkDB: NP_803172
Original site: NP_803172 
LOCUS       NP_803172               1185 aa            linear   PRI 26-AUG-2018
DEFINITION  liprin-alpha-1 isoform a [Homo sapiens].
ACCESSION   NP_803172
VERSION     NP_803172.1
DBSOURCE    REFSEQ: accession NM_177423.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1185)
  AUTHORS   Yang J, Wu NN, Huang DJ, Luo YC, Huang JZ, He HY, Lu HL and Song
            WL.
  TITLE     PPFIA1 is upregulated in liver metastasis of breast cancer and is a
            potential poor prognostic indicator of metastatic relapse
  JOURNAL   Tumour Biol. 39 (7), 1010428317713492 (2017)
   PUBMED   28720060
  REMARK    GeneRIF: Based on these findings, we infer that high PPFIA1
            expression might be an independent prognostic indicator of
            increased metastatic relapse risk in patients with estrogen
            receptor+/N- breast cancer, but not in estrogen receptor+/N+ or
            estrogen receptor- patients.
REFERENCE   2  (residues 1 to 1185)
  AUTHORS   Mana G, Clapero F, Panieri E, Panero V, Bottcher RT, Tseng HY,
            Saltarin F, Astanina E, Wolanska KI, Morgan MR, Humphries MJ,
            Santoro MM, Serini G and Valdembri D.
  TITLE     PPFIA1 drives active alpha5beta1 integrin recycling and controls
            fibronectin fibrillogenesis and vascular morphogenesis
  JOURNAL   Nat Commun 7, 13546 (2016)
   PUBMED   27876801
  REMARK    GeneRIF: This study shows that PPFIA1 is required for FN
            polymerization-dependent vascular morphogenesis, both in vitro and
            in the developing zebrafish embryo.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1185)
  AUTHORS   Pehkonen H, von Nandelstadh P, Karhemo PR, Lepikhova T, Grenman R,
            Lehti K and Monni O.
  TITLE     Liprin-alpha1 is a regulator of vimentin intermediate filament
            network in the cancer cell adhesion machinery
  JOURNAL   Sci Rep 6, 24486 (2016)
   PUBMED   27075696
  REMARK    GeneRIF: These results indicate that liprin-alpha1 localizes to
            different adhesion and cytoskeletal structures to regulate vimentin
            intermediate filament network, thereby altering the invasion and
            growth properties of the cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1185)
  AUTHORS   Chiaretti S, Astro V, Chiricozzi E and de Curtis I.
  TITLE     Effects of the scaffold proteins liprin-alpha1, beta1 and beta2 on
            invasion by breast cancer cells
  JOURNAL   Biol. Cell 108 (3), 65-75 (2016)
   PUBMED   26663347
  REMARK    GeneRIF: The human tumor cell line MDA-MB-231 expresses
            liprin-alpha 1 and is able to promote the formation of metastasis
            in mice.
REFERENCE   5  (residues 1 to 1185)
  AUTHORS   Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA,
            Weisswange I, Mansfeld J, Buchholz F, Hyman AA and Mann M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   6  (residues 1 to 1185)
  AUTHORS   Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT,
            Weinberg RJ and Kim E.
  TITLE     Interaction between liprin-alpha and GIT1 is required for AMPA
            receptor targeting
  JOURNAL   J. Neurosci. 23 (5), 1667-1677 (2003)
   PUBMED   12629171
REFERENCE   7  (residues 1 to 1185)
  AUTHORS   Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG,
            Serra-Pages C, Streuli M, Weinberg RJ and Sheng M.
  TITLE     Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA
            receptor targeting
  JOURNAL   Neuron 34 (1), 39-52 (2002)
   PUBMED   11931740
REFERENCE   8  (residues 1 to 1185)
  AUTHORS   Serra-Pages C, Medley QG, Tang M, Hart A and Streuli M.
  TITLE     Liprins, a family of LAR transmembrane protein-tyrosine
            phosphatase-interacting proteins
  JOURNAL   J. Biol. Chem. 273 (25), 15611-15620 (1998)
   PUBMED   9624153
REFERENCE   9  (residues 1 to 1185)
  AUTHORS   Pulido R, Serra-Pages C, Tang M and Streuli M.
  TITLE     The LAR/PTP delta/PTP sigma subfamily of transmembrane
            protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and
            PTP sigma isoforms are expressed in a tissue-specific manner and
            associate with the LAR-interacting protein LIP.1
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (25), 11686-11690 (1995)
   PUBMED   8524829
REFERENCE   10 (residues 1 to 1185)
  AUTHORS   Serra-Pages C, Kedersha NL, Fazikas L, Medley Q, Debant A and
            Streuli M.
  TITLE     The LAR transmembrane protein tyrosine phosphatase and a
            coiled-coil LAR-interacting protein co-localize at focal adhesions
  JOURNAL   EMBO J. 14 (12), 2827-2838 (1995)
   PUBMED   7796809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW163189.1, U22815.1 and BF352121.1.
            
            Summary: The protein encoded by this gene is a member of the LAR
            protein-tyrosine phosphatase-interacting protein (liprin) family.
            Liprins interact with members of LAR family of transmembrane
            protein tyrosine phosphatases, which are known to be important for
            axon guidance and mammary gland development. This protein binds to
            the intracellular membrane-distal phosphatase domain of tyrosine
            phosphatase LAR, and appears to localize LAR to cell focal
            adhesions. This interaction may regulate the disassembly of focal
            adhesion and thus help orchestrate cell-matrix interactions.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs in the 3' end, which
            includes a part of the coding region and 3' UTR, as compared to
            variant 2. The resulting protein (isoform a) has a distinct and
            shorter C-terminus, as compared to isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U22815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1185
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.3"
     Protein         1..1185
                     /product="liprin-alpha-1 isoform a"
                     /note="Liprin-alpha1; LAR-interacting protein 1;
                     liprin-alpha-1; LIP-1; protein tyrosine phosphatase
                     receptor type f polypeptide-interacting protein alpha-1;
                     protein tyrosine phosphatase, receptor type, f polypeptide
                     (PTPRF), interacting protein (liprin), alpha 1"
                     /calculated_mol_wt=133839
     variation       3
                     /replace="c"
                     /db_xref="dbSNP:137873718"
     variation       3
                     /replace="s"
                     /db_xref="dbSNP:1435129977"
     variation       4
                     /replace="k"
                     /db_xref="dbSNP:765770151"
     variation       5
                     /replace="v"
                     /db_xref="dbSNP:752284452"
     variation       9
                     /replace="i"
                     /db_xref="dbSNP:372416850"
     variation       10
                     /replace="s"
                     /db_xref="dbSNP:763700052"
     variation       11
                     /replace="k"
                     /db_xref="dbSNP:751196245"
     variation       12
                     /replace="t"
                     /db_xref="dbSNP:1305768912"
     variation       12
                     /replace="v"
                     /db_xref="dbSNP:1342702269"
     variation       14
                     /replace="c"
                     /db_xref="dbSNP:1308137917"
     variation       14
                     /replace="d"
                     /db_xref="dbSNP:757070614"
     variation       14
                     /replace="g"
                     /db_xref="dbSNP:1235515945"
     variation       15
                     /replace="h"
                     /db_xref="dbSNP:780955016"
     variation       15
                     /replace="p"
                     /db_xref="dbSNP:1284137479"
     variation       15
                     /replace="s"
                     /db_xref="dbSNP:1276918543"
     variation       16
                     /replace="a"
                     /db_xref="dbSNP:745607765"
     variation       16
                     /replace="l"
                     /db_xref="dbSNP:1280030441"
     variation       17
                     /replace="g"
                     /db_xref="dbSNP:756051521"
     variation       18
                     /replace="r"
                     /db_xref="dbSNP:142092302"
     variation       19
                     /replace="d"
                     /db_xref="dbSNP:778985978"
     variation       21
                     /replace="d"
                     /db_xref="dbSNP:145854073"
     variation       21
                     /replace="g"
                     /db_xref="dbSNP:112711299"
     variation       22
                     /replace="r"
                     /db_xref="dbSNP:1196771692"
     variation       22
                     /replace="y"
                     /db_xref="dbSNP:1275379618"
     variation       23
                     /replace="d"
                     /db_xref="dbSNP:773372181"
     variation       24
                     /replace="s"
                     /db_xref="dbSNP:547927770"
     variation       25
                     /replace="c"
                     /db_xref="dbSNP:770999735"
     variation       27
                     /replace="a"
                     /db_xref="dbSNP:376508528"
     variation       29
                     /replace="h"
                     /db_xref="dbSNP:35662360"
     variation       31
                     /replace="n"
                     /db_xref="dbSNP:539083991"
     variation       32
                     /replace="t"
                     /db_xref="dbSNP:199937660"
     variation       36
                     /replace="s"
                     /db_xref="dbSNP:1048280234"
     variation       40
                     /replace="t"
                     /db_xref="dbSNP:1330040756"
     variation       40
                     /replace="v"
                     /db_xref="dbSNP:1463623012"
     variation       42
                     /replace="s"
                     /db_xref="dbSNP:889640675"
     variation       43
                     /replace="l"
                     /db_xref="dbSNP:141943495"
     variation       44
                     /replace="l"
                     /db_xref="dbSNP:370960981"
     variation       45
                     /replace="a"
                     /db_xref="dbSNP:751231282"
     variation       47
                     /replace="r"
                     /db_xref="dbSNP:150654724"
     variation       49
                     /replace="c"
                     /db_xref="dbSNP:767091744"
     variation       49
                     /replace="h"
                     /db_xref="dbSNP:750251702"
     variation       50
                     /replace="p"
                     /db_xref="dbSNP:755855153"
     variation       52
                     /replace="d"
                     /db_xref="dbSNP:1021941301"
     variation       52
                     /replace="g"
                     /db_xref="dbSNP:753809218"
     variation       52
                     /replace="n"
                     /db_xref="dbSNP:780016518"
     variation       53
                     /replace="a"
                     /db_xref="dbSNP:138949843"
     variation       53
                     /replace="k"
                     /db_xref="dbSNP:999495753"
     variation       53
                     /replace="t"
                     /db_xref="dbSNP:777919938"
     variation       54
                     /replace="l"
                     /db_xref="dbSNP:1450866541"
     variation       54
                     /replace="l"
                     /db_xref="dbSNP:746993453"
     variation       57
                     /replace="t"
                     /db_xref="dbSNP:1208440489"
     variation       58
                     /replace="p"
                     /db_xref="dbSNP:997561534"
     variation       58
                     /replace="q"
                     /db_xref="dbSNP:1374751569"
     variation       60
                     /replace="m"
                     /db_xref="dbSNP:771307289"
     variation       62
                     /replace="a"
                     /db_xref="dbSNP:1169859180"
     variation       62
                     /replace="t"
                     /db_xref="dbSNP:1273933532"
     variation       64
                     /replace="h"
                     /db_xref="dbSNP:865791545"
     variation       64
                     /replace="t"
                     /db_xref="dbSNP:1214088196"
     variation       65
                     /replace="p"
                     /db_xref="dbSNP:1349477311"
     variation       66
                     /replace="r"
                     /db_xref="dbSNP:781513604"
     variation       67
                     /replace="k"
                     /db_xref="dbSNP:746280559"
     variation       67
                     /replace="r"
                     /db_xref="dbSNP:1316200223"
     variation       68
                     /replace="l"
                     /db_xref="dbSNP:770248829"
     variation       69
                     /replace="h"
                     /db_xref="dbSNP:374418182"
     variation       69
                     /replace="r"
                     /db_xref="dbSNP:1386596133"
     variation       69
                     /replace="y"
                     /db_xref="dbSNP:775932473"
     variation       70
                     /replace="e"
                     /db_xref="dbSNP:960478965"
     variation       70
                     /replace="k"
                     /db_xref="dbSNP:966958852"
     variation       71
                     /replace="i"
                     /db_xref="dbSNP:546502"
     variation       73
                     /replace="h"
                     /db_xref="dbSNP:1355948502"
     variation       73
                     /replace="y"
                     /db_xref="dbSNP:1335594001"
     variation       76
                     /replace="d"
                     /db_xref="dbSNP:773920211"
     variation       76
                     /replace="n"
                     /db_xref="dbSNP:925427705"
     variation       77
                     /replace="c"
                     /db_xref="dbSNP:202118330"
     variation       81
                     /replace="q"
                     /db_xref="dbSNP:1390297887"
     variation       83
                     /replace="k"
                     /db_xref="dbSNP:959538943"
     variation       84
                     /replace="m"
                     /db_xref="dbSNP:767181650"
     variation       84
                     /replace="t"
                     /db_xref="dbSNP:146309528"
     variation       85
                     /replace="s"
                     /db_xref="dbSNP:750055227"
     variation       85
                     /replace="v"
                     /db_xref="dbSNP:760504380"
     variation       88
                     /replace="r"
                     /db_xref="dbSNP:1192909472"
     variation       90
                     /replace="f"
                     /db_xref="dbSNP:770312900"
     variation       91
                     /replace="a"
                     /db_xref="dbSNP:532532963"
     variation       91
                     /replace="t"
                     /db_xref="dbSNP:199844505"
     variation       92
                     /replace="a"
                     /db_xref="dbSNP:1463817181"
     variation       92
                     /replace="t"
                     /db_xref="dbSNP:1010287956"
     variation       93
                     /replace="l"
                     /db_xref="dbSNP:1019571656"
     variation       93
                     /replace="v"
                     /db_xref="dbSNP:1403758377"
     variation       94
                     /replace="a"
                     /db_xref="dbSNP:1164327148"
     variation       94
                     /replace="s"
                     /db_xref="dbSNP:547809296"
     variation       95
                     /replace="e"
                     /db_xref="dbSNP:903419253"
     variation       96
                     /replace="d"
                     /db_xref="dbSNP:769433545"
     variation       98
                     /replace="d"
                     /db_xref="dbSNP:999093848"
     variation       98
                     /replace="k"
                     /db_xref="dbSNP:1331735002"
     variation       98
                     /replace="s"
                     /db_xref="dbSNP:139495969"
     variation       99
                     /replace="a"
                     /db_xref="dbSNP:1273298530"
     variation       99
                     /replace="i"
                     /db_xref="dbSNP:551544898"
     variation       103
                     /replace="q"
                     /db_xref="dbSNP:1432523506"
     variation       104
                     /replace="l"
                     /db_xref="dbSNP:1321236140"
     variation       105
                     /replace="f"
                     /db_xref="dbSNP:569854139"
     variation       105
                     /replace="l"
                     /db_xref="dbSNP:1337190842"
     variation       106
                     /replace="a"
                     /db_xref="dbSNP:1268692133"
     variation       106
                     /replace="e"
                     /db_xref="dbSNP:1285390604"
     variation       106
                     /replace="k"
                     /db_xref="dbSNP:1229936867"
     variation       107
                     /replace="r"
                     /db_xref="dbSNP:1376332724"
     variation       108
                     /replace="e"
                     /db_xref="dbSNP:760849319"
     variation       108
                     /replace="g"
                     /db_xref="dbSNP:144335013"
     variation       109
                     /replace="e"
                     /db_xref="dbSNP:1354936122"
     variation       111
                     /replace="f"
                     /db_xref="dbSNP:1219181599"
     variation       112
                     /replace="a"
                     /db_xref="dbSNP:1447937526"
     variation       115
                     /replace="k"
                     /db_xref="dbSNP:766366310"
     variation       116
                     /replace="a"
                     /db_xref="dbSNP:754149473"
     variation       119
                     /replace="s"
                     /db_xref="dbSNP:927569498"
     variation       120
                     /replace="n"
                     /db_xref="dbSNP:1483187518"
     variation       121
                     /replace="i"
                     /db_xref="dbSNP:1210929380"
     variation       126
                     /replace="g"
                     /db_xref="dbSNP:759612054"
     variation       127
                     /replace="h"
                     /db_xref="dbSNP:765491741"
     variation       129
                     /replace="e"
                     /db_xref="dbSNP:1388470876"
     variation       130
                     /replace="w"
                     /db_xref="dbSNP:752881054"
     variation       130
                     /replace="y"
                     /db_xref="dbSNP:1379533308"
     variation       133
                     /replace="s"
                     /db_xref="dbSNP:1157587642"
     variation       135
                     /replace="h"
                     /db_xref="dbSNP:763371043"
     variation       136
                     /replace="e"
                     /db_xref="dbSNP:369798711"
     variation       137
                     /replace="q"
                     /db_xref="dbSNP:1413440442"
     variation       137
                     /replace="w"
                     /db_xref="dbSNP:764425609"
     variation       141
                     /replace="l"
                     /db_xref="dbSNP:371918990"
     variation       142
                     /replace="t"
                     /db_xref="dbSNP:144282210"
     variation       143
                     /replace="l"
                     /db_xref="dbSNP:757711997"
     variation       144
                     /replace="a"
                     /db_xref="dbSNP:1444198298"
     variation       145
                     /replace="e"
                     /db_xref="dbSNP:781696901"
     variation       147
                     /replace="r"
                     /db_xref="dbSNP:1174776670"
     variation       148
                     /replace="a"
                     /db_xref="dbSNP:755632385"
     variation       148
                     /replace="t"
                     /db_xref="dbSNP:1335586949"
     variation       148
                     /replace="v"
                     /db_xref="dbSNP:749928660"
     variation       150
                     /replace="c"
                     /db_xref="dbSNP:779894257"
     variation       150
                     /replace="s"
                     /db_xref="dbSNP:541397539"
     Site            150
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q13136.1)"
     variation       151
                     /replace="l"
                     /db_xref="dbSNP:1320093340"
     variation       151
                     /replace="p"
                     /db_xref="dbSNP:1246034450"
     variation       151
                     /replace="s"
                     /db_xref="dbSNP:111283320"
     variation       152
                     /replace="t"
                     /db_xref="dbSNP:969145598"
     variation       153
                     /replace="g"
                     /db_xref="dbSNP:148677249"
     variation       153
                     /replace="r"
                     /db_xref="dbSNP:959183964"
     variation       154
                     /replace="m"
                     /db_xref="dbSNP:756011012"
     variation       154
                     /replace="v"
                     /db_xref="dbSNP:1451991688"
     variation       155
                     /replace="a"
                     /db_xref="dbSNP:1200679688"
     variation       156
                     /replace="s"
                     /db_xref="dbSNP:879794411"
     variation       159
                     /replace="g"
                     /db_xref="dbSNP:771923824"
     variation       161
                     /replace="l"
                     /db_xref="dbSNP:773179632"
     variation       162
                     /replace="r"
                     /db_xref="dbSNP:745973350"
     variation       163
                     /replace="a"
                     /db_xref="dbSNP:1319025869"
     variation       164
                     /replace="l"
                     /db_xref="dbSNP:1455008368"
     variation       169
                     /replace="g"
                     /db_xref="dbSNP:1463577421"
     variation       174
                     /replace="h"
                     /db_xref="dbSNP:1169579159"
     variation       178
                     /replace="a"
                     /db_xref="dbSNP:1389079586"
     variation       178
                     /replace="v"
                     /db_xref="dbSNP:778576242"
     variation       181
                     /replace="q"
                     /db_xref="dbSNP:372608196"
     variation       183
                     /replace="q"
                     /db_xref="dbSNP:758180487"
     variation       185
                     /replace="t"
                     /db_xref="dbSNP:777634329"
     variation       186
                     /replace="l"
                     /db_xref="dbSNP:1294872203"
     variation       187
                     /replace="a"
                     /db_xref="dbSNP:948971125"
     variation       187
                     /replace="k"
                     /db_xref="dbSNP:1024598557"
     variation       189
                     /replace="r"
                     /db_xref="dbSNP:746947701"
     variation       190
                     /replace="n"
                     /db_xref="dbSNP:1282611906"
     variation       191
                     /replace="w"
                     /db_xref="dbSNP:1249103931"
     variation       194
                     /replace="e"
                     /db_xref="dbSNP:775549236"
     variation       194
                     /replace="k"
                     /db_xref="dbSNP:770794922"
     variation       196
                     /replace="f"
                     /db_xref="dbSNP:1208615300"
     variation       198
                     /replace="a"
                     /db_xref="dbSNP:1239925296"
     variation       198
                     /replace="v"
                     /db_xref="dbSNP:1288113150"
     variation       199
                     /replace="a"
                     /db_xref="dbSNP:368688567"
     variation       205
                     /replace="v"
                     /db_xref="dbSNP:1206223391"
     variation       206
                     /replace="l"
                     /db_xref="dbSNP:1198192920"
     variation       208
                     /replace="q"
                     /db_xref="dbSNP:748390540"
     variation       212
                     /replace="r"
                     /db_xref="dbSNP:770254855"
     variation       213
                     /replace="e"
                     /db_xref="dbSNP:142170424"
     variation       214
                     /replace="r"
                     /db_xref="dbSNP:201970155"
     variation       215
                     /replace="i"
                     /db_xref="dbSNP:773764044"
     variation       218
                     /replace="e"
                     /db_xref="dbSNP:1378669202"
     variation       218
                     /replace="g"
                     /db_xref="dbSNP:369965878"
     variation       218
                     /replace="h"
                     /db_xref="dbSNP:1417667192"
     variation       219
                     /replace="e"
                     /db_xref="dbSNP:201134555"
     variation       220
                     /replace="a"
                     /db_xref="dbSNP:571405866"
     variation       220
                     /replace="v"
                     /db_xref="dbSNP:759183650"
     variation       221
                     /replace="p"
                     /db_xref="dbSNP:764786699"
     variation       222
                     /replace="e"
                     /db_xref="dbSNP:373950779"
     variation       222
                     /replace="g"
                     /db_xref="dbSNP:1333582554"
     variation       222
                     /replace="n"
                     /db_xref="dbSNP:1457477811"
     variation       225
                     /replace="r"
                     /db_xref="dbSNP:762668966"
     variation       226
                     /replace="e"
                     /db_xref="dbSNP:757026360"
     variation       226
                     /replace="g"
                     /db_xref="dbSNP:751381400"
     variation       226
                     /replace="k"
                     /db_xref="dbSNP:763612171"
     variation       227
                     /replace="q"
                     /db_xref="dbSNP:532296062"
     variation       230
                     /replace="a"
                     /db_xref="dbSNP:750360108"
     variation       230
                     /replace="i"
                     /db_xref="dbSNP:151186142"
     Site            230
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000244|PubMed:18669648};
                     propagated from UniProtKB/Swiss-Prot (Q13136.1)"
     variation       231
                     /replace="t"
                     /db_xref="dbSNP:748111587"
     variation       232
                     /replace="g"
                     /db_xref="dbSNP:1479875408"
     variation       232
                     /replace="s"
                     /db_xref="dbSNP:141458298"
     variation       233
                     /replace="m"
                     /db_xref="dbSNP:778116748"
     variation       233
                     /replace="t"
                     /db_xref="dbSNP:376891820"
     variation       234
                     /replace="s"
                     /db_xref="dbSNP:1017730061"
     variation       237
                     /replace="s"
                     /db_xref="dbSNP:1417658543"
     variation       239
                     /replace="f"
                     /db_xref="dbSNP:752868284"
     variation       239
                     /replace="s"
                     /db_xref="dbSNP:1289017338"
     Site            239
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:19690332,
                     ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q13136.1)"
     variation       241
                     /replace="g"
                     /db_xref="dbSNP:183179626"
     variation       242
                     /replace="f"
                     /db_xref="dbSNP:747220973"
     variation       242
                     /replace="p"
                     /db_xref="dbSNP:778206650"
     Site            242
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:21406692,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q13136.1)"
     variation       243
                     /replace="i"
                     /db_xref="dbSNP:929356076"
     variation       243
                     /replace="l"
                     /db_xref="dbSNP:781691316"
     variation       243
                     /replace="s"
                     /db_xref="dbSNP:757492175"
     variation       244
                     /replace="r"
                     /db_xref="dbSNP:1267839677"
     variation       244
                     /replace="r"
                     /db_xref="dbSNP:534856862"
     variation       244
                     /replace="s"
                     /db_xref="dbSNP:1360656578"
     Site            244
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:21406692}; propagated from
                     UniProtKB/Swiss-Prot (Q13136.1)"
     variation       245
                     /replace="h"
                     /db_xref="dbSNP:374093821"
     variation       245
                     /replace="y"
                     /db_xref="dbSNP:1228571347"
     variation       246
                     /replace="k"
                     /db_xref="dbSNP:748873005"
     variation       247
                     /replace="k"
                     /db_xref="dbSNP:768050412"
     variation       248
                     /replace="d"
                     /db_xref="dbSNP:1021651575"
     variation       253
                     /replace="t"
                     /db_xref="dbSNP:553550128"
     variation       253
                     /replace="v"
                     /db_xref="dbSNP:1273444698"
     variation       255
                     /replace="r"
                     /db_xref="dbSNP:1174500541"
     variation       256
                     /replace="q"
                     /db_xref="dbSNP:761468787"
     variation       258
                     /replace="i"
                     /db_xref="dbSNP:773023201"
     variation       258
                     /replace="l"
                     /db_xref="dbSNP:767091610"
     variation       259
                     /replace="v"
                     /db_xref="dbSNP:760340499"
     variation       262
                     /replace="r"
                     /db_xref="dbSNP:1192187355"
     variation       263
                     /replace="p"
                     /db_xref="dbSNP:766377601"
     variation       264
                     /replace="g"
                     /db_xref="dbSNP:1182710746"
     variation       264
                     /replace="k"
                     /db_xref="dbSNP:753713376"
     variation       264
                     /replace="r"
                     /db_xref="dbSNP:758563039"
     variation       269
                     /replace="v"
                     /db_xref="dbSNP:1215775543"
     variation       270
                     /replace="k"
                     /db_xref="dbSNP:578241077"
     variation       272
                     /replace="c"
                     /db_xref="dbSNP:1380857828"
     variation       272
                     /replace="h"
                     /db_xref="dbSNP:757580695"
     variation       274
                     /replace="t"
                     /db_xref="dbSNP:145283300"
     variation       275
                     /replace="f"
                     /db_xref="dbSNP:746291376"
     variation       275
                     /replace="s"
                     /db_xref="dbSNP:143160253"
     variation       276
                     /replace="f"
                     /db_xref="dbSNP:1343894151"
     variation       277
                     /replace="p"
                     /db_xref="dbSNP:780680851"
     variation       277
                     /replace="s"
                     /db_xref="dbSNP:141950926"
     variation       278
                     /replace="g"
                     /db_xref="dbSNP:370632677"
     variation       279
                     /replace="h"
                     /db_xref="dbSNP:1380039613"
     variation       279
                     /replace="r"
                     /db_xref="dbSNP:1365739318"
     variation       279
                     /replace="y"
                     /db_xref="dbSNP:1304262186"
     variation       280
                     /replace="m"
                     /db_xref="dbSNP:374990716"
     variation       281
                     /replace="r"
                     /db_xref="dbSNP:972944266"
     variation       281
                     /replace="t"
                     /db_xref="dbSNP:367711290"
     variation       283
                     /replace="p"
                     /db_xref="dbSNP:1354866315"
     variation       285
                     /replace="e"
                     /db_xref="dbSNP:371447345"
     variation       285
                     /replace="g"
                     /db_xref="dbSNP:918832459"
     variation       287
                     /replace="p"
                     /db_xref="dbSNP:1375073873"
     variation       289
                     /replace="m"
                     /db_xref="dbSNP:150126116"
     variation       289
                     /replace="s"
                     /db_xref="dbSNP:1282738471"
     variation       289
                     /replace="t"
                     /db_xref="dbSNP:772707467"
     variation       291
                     /replace="g"
                     /db_xref="dbSNP:1239435375"
     variation       291
                     /replace="k"
                     /db_xref="dbSNP:760584517"
     variation       292
                     /replace="r"
                     /db_xref="dbSNP:766073824"
     variation       293
                     /replace="y"
                     /db_xref="dbSNP:1238604218"
     variation       294
                     /replace="i"
                     /db_xref="dbSNP:1186422993"
     variation       294
                     /replace="p"
                     /db_xref="dbSNP:371601197"
     variation       296
                     /replace="r"
                     /db_xref="dbSNP:374865980"
     variation       297
                     /replace="f"
                     /db_xref="dbSNP:765222959"
     variation       300
                     /replace="i"
                     /db_xref="dbSNP:761959381"
     variation       300
                     /replace="k"
                     /db_xref="dbSNP:751708592"
     variation       301
                     /replace="d"
                     /db_xref="dbSNP:767894128"
     variation       301
                     /replace="n"
                     /db_xref="dbSNP:750608248"
     variation       302
                     /replace="a"
                     /db_xref="dbSNP:756561361"
     variation       302
                     /replace="k"
                     /db_xref="dbSNP:780296014"
     variation       303
                     /replace="e"
                     /db_xref="dbSNP:1444750142"
     variation       304
                     /replace="l"
                     /db_xref="dbSNP:1020695535"
     variation       306
                     /replace="q"
                     /db_xref="dbSNP:369007992"
     variation       307
                     /replace="g"
                     /db_xref="dbSNP:545666786"
     variation       308
                     /replace="v"
                     /db_xref="dbSNP:1277511750"
     variation       309
                     /replace="c"
                     /db_xref="dbSNP:779346245"
     variation       309
                     /replace="h"
                     /db_xref="dbSNP:902270154"
     variation       312
                     /replace="t"
                     /db_xref="dbSNP:766587899"
     variation       313
                     /replace="t"
                     /db_xref="dbSNP:1474254976"
     variation       314
                     /replace="q"
                     /db_xref="dbSNP:138459318"
     variation       315
                     /replace="k"
                     /db_xref="dbSNP:1396278815"
     variation       316
                     /replace="e"
                     /db_xref="dbSNP:755315940"
     variation       316
                     /replace="g"
                     /db_xref="dbSNP:200620756"
     variation       318
                     /replace="t"
                     /db_xref="dbSNP:779461821"
     variation       319
                     /replace="e"
                     /db_xref="dbSNP:753187253"
     Region          321..517
                     /region_name="MscS_porin"
                     /note="Mechanosensitive ion channel porin domain;
                     pfam12795"
                     /db_xref="CDD:289559"
     variation       321
                     /replace="r"
                     /db_xref="dbSNP:1331533183"
     Region          <324..>445
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:299863"
     variation       324
                     /replace="a"
                     /db_xref="dbSNP:1278983724"
     variation       327
                     /replace="r"
                     /db_xref="dbSNP:947135974"
     variation       328
                     /replace="c"
                     /db_xref="dbSNP:768572652"
     variation       328
                     /replace="h"
                     /db_xref="dbSNP:1225576413"
     variation       329
                     /replace="c"
                     /db_xref="dbSNP:922268226"
     variation       329
                     /replace="y"
                     /db_xref="dbSNP:777148349"
     variation       330
                     /replace="l"
                     /db_xref="dbSNP:186057891"
     variation       330
                     /replace="s"
                     /db_xref="dbSNP:776303865"
     variation       331
                     /replace="a"
                     /db_xref="dbSNP:199854772"
     variation       331
                     /replace="d"
                     /db_xref="dbSNP:780874845"
     variation       331
                     /replace="t"
                     /db_xref="dbSNP:148840074"
     variation       332
                     /replace="a"
                     /db_xref="dbSNP:1484534281"
     variation       334
                     /replace="c"
                     /db_xref="dbSNP:568113048"
     variation       334
                     /replace="h"
                     /db_xref="dbSNP:762999066"
     variation       334
                     /replace="r"
                     /db_xref="dbSNP:768572987"
     variation       335
                     /replace="k"
                     /db_xref="dbSNP:75907709"
     variation       336
                     /replace="v"
                     /db_xref="dbSNP:1368644996"
     variation       337
                     /replace="t"
                     /db_xref="dbSNP:1208811374"
     variation       338
                     /replace="p"
                     /db_xref="dbSNP:1320853103"
     variation       340
                     /replace="r"
                     /db_xref="dbSNP:916549293"
     variation       343
                     /replace="d"
                     /db_xref="dbSNP:373756931"
     variation       343
                     /replace="s"
                     /db_xref="dbSNP:1383762906"
     variation       344
                     /replace="n"
                     /db_xref="dbSNP:905552351"
     variation       344
                     /replace="v"
                     /db_xref="dbSNP:776805756"
     variation       345
                     /replace="-"
                     /db_xref="dbSNP:761390448"
     variation       347
                     /replace="e"
                     /db_xref="dbSNP:752989198"
     variation       347
                     /replace="k"
                     /db_xref="dbSNP:759948657"
     variation       348
                     /replace="n"
                     /db_xref="dbSNP:1387301071"
     variation       350
                     /replace="t"
                     /db_xref="dbSNP:1293185855"
     variation       351
                     /replace="a"
                     /db_xref="dbSNP:758930675"
     variation       352
                     /replace="s"
                     /db_xref="dbSNP:764612473"
     variation       353
                     /replace="e"
                     /db_xref="dbSNP:1483112303"
     variation       353
                     /replace="k"
                     /db_xref="dbSNP:751078215"
     variation       354
                     /replace="g"
                     /db_xref="dbSNP:756758853"
     variation       355
                     /replace="t"
                     /db_xref="dbSNP:1312720685"
     variation       356
                     /replace="r"
                     /db_xref="dbSNP:1450184640"
     variation       356
                     /replace="v"
                     /db_xref="dbSNP:535218853"
     variation       357
                     /replace="r"
                     /db_xref="dbSNP:1404029485"
     variation       358
                     /replace="p"
                     /db_xref="dbSNP:745504916"
     variation       358
                     /replace="r"
                     /db_xref="dbSNP:577226515"
     variation       362
                     /replace="e"
                     /db_xref="dbSNP:201954774"
     variation       362
                     /replace="g"
                     /db_xref="dbSNP:143350650"
     variation       364
                     /replace="d"
                     /db_xref="dbSNP:763353351"
     variation       365
                     /replace="c"
                     /db_xref="dbSNP:764547561"
     variation       365
                     /replace="h"
                     /db_xref="dbSNP:553765591"
     variation       368
                     /replace="r"
                     /db_xref="dbSNP:1253299446"
     variation       369
                     /replace="e"
                     /db_xref="dbSNP:756776453"
     variation       370
                     /replace="c"
                     /db_xref="dbSNP:767149740"
     variation       370
                     /replace="h"
                     /db_xref="dbSNP:376830476"
     variation       374
                     /replace="a"
                     /db_xref="dbSNP:749886519"
     variation       376
                     /replace="k"
                     /db_xref="dbSNP:79783439"
     variation       376
                     /replace="r"
                     /db_xref="dbSNP:755862919"
     variation       378
                     /replace="l"
                     /db_xref="dbSNP:1405537094"
     variation       378
                     /replace="l"
                     /db_xref="dbSNP:779808412"
     variation       379
                     /replace="q"
                     /db_xref="dbSNP:749147605"
     variation       380
                     /replace="e"
                     /db_xref="dbSNP:1287735846"
     variation       382
                     /replace="l"
                     /db_xref="dbSNP:754774570"
     variation       383
                     /replace="g"
                     /db_xref="dbSNP:1390790908"
     variation       384
                     /replace="k"
                     /db_xref="dbSNP:772831089"
     variation       385
                     /replace="a"
                     /db_xref="dbSNP:778785947"
     variation       386
                     /replace="d"
                     /db_xref="dbSNP:1346876840"
     variation       387
                     /replace="a"
                     /db_xref="dbSNP:1221116357"
     variation       387
                     /replace="t"
                     /db_xref="dbSNP:202040644"
     variation       389
                     /replace="p"
                     /db_xref="dbSNP:771835705"
     variation       391
                     /replace="g"
                     /db_xref="dbSNP:1206163072"
     variation       392
                     /replace="v"
                     /db_xref="dbSNP:776719992"
     variation       393
                     /replace="a"
                     /db_xref="dbSNP:770050858"
     variation       393
                     /replace="v"
                     /db_xref="dbSNP:200901690"
     variation       397
                     /replace="r"
                     /db_xref="dbSNP:1270167137"
     variation       400
                     /replace="s"
                     /db_xref="dbSNP:757300030"
     variation       401
                     /replace="a"
                     /db_xref="dbSNP:775657756"
     variation       401
                     /replace="p"
                     /db_xref="dbSNP:1226224897"
     variation       401
                     /replace="v"
                     /db_xref="dbSNP:1325359117"
     variation       402
                     /replace="p"
                     /db_xref="dbSNP:1222713115"
     variation       403
                     /replace="s"
                     /db_xref="dbSNP:1428669669"
     variation       404
                     /replace="n"
                     /db_xref="dbSNP:763293373"
     variation       404
                     /replace="r"
                     /db_xref="dbSNP:939094451"
     variation       405
                     /replace="v"
                     /db_xref="dbSNP:758158240"
     variation       408
                     /replace="*"
                     /db_xref="dbSNP:760350769"
     variation       409
                     /replace="h"
                     /db_xref="dbSNP:142274531"
     variation       410
                     /replace="g"
                     /db_xref="dbSNP:751483712"
     variation       410
                     /replace="r"
                     /db_xref="dbSNP:1285436565"
     variation       411
                     /replace="d"
                     /db_xref="dbSNP:1200087044"
     variation       411
                     /replace="s"
                     /db_xref="dbSNP:1456522569"
     variation       412
                     /replace="i"
                     /db_xref="dbSNP:1439315773"
     variation       412
                     /replace="t"
                     /db_xref="dbSNP:1273496901"
     variation       415
                     /replace="r"
                     /db_xref="dbSNP:757126498"
     variation       417
                     /replace="g"
                     /db_xref="dbSNP:1232189475"
     variation       417
                     /replace="q"
                     /db_xref="dbSNP:780188154"
     variation       418
                     /replace="q"
                     /db_xref="dbSNP:1406606473"
     variation       419
                     /replace="k"
                     /db_xref="dbSNP:1426569014"
     variation       419
                     /replace="v"
                     /db_xref="dbSNP:1200883056"
     variation       421
                     /replace="v"
                     /db_xref="dbSNP:749289148"
     variation       423
                     /replace="v"
                     /db_xref="dbSNP:373655434"
     variation       424
                     /replace="e"
                     /db_xref="dbSNP:1420733683"
     variation       424
                     /replace="k"
                     /db_xref="dbSNP:778982040"
     variation       426
                     /replace="e"
                     /db_xref="dbSNP:1270314459"
     variation       426
                     /replace="n"
                     /db_xref="dbSNP:758954979"
     variation       427
                     /replace="n"
                     /db_xref="dbSNP:1164818481"
     variation       430
                     /replace="l"
                     /db_xref="dbSNP:1209686598"
     variation       431
                     /replace="q"
                     /db_xref="dbSNP:748589131"
     variation       432
                     /replace="q"
                     /db_xref="dbSNP:772564997"
     variation       433
                     /replace="a"
                     /db_xref="dbSNP:1159275815"
     variation       433
                     /replace="t"
                     /db_xref="dbSNP:747325450"
     variation       435
                     /replace="q"
                     /db_xref="dbSNP:142762894"
     variation       438
                     /replace="t"
                     /db_xref="dbSNP:1348081466"
     variation       439
                     /replace="l"
                     /db_xref="dbSNP:1399220416"
     variation       440
                     /replace="n"
                     /db_xref="dbSNP:565338552"
     variation       443
                     /replace="r"
                     /db_xref="dbSNP:1383289403"
     variation       445
                     /replace="n"
                     /db_xref="dbSNP:1279166169"
     variation       446
                     /replace="c"
                     /db_xref="dbSNP:753068055"
     variation       446
                     /replace="h"
                     /db_xref="dbSNP:1312841686"
     variation       447
                     /replace="l"
                     /db_xref="dbSNP:1231751796"
     variation       448
                     /replace="s"
                     /db_xref="dbSNP:745449850"
     Site            448
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:21406692};
                     propagated from UniProtKB/Swiss-Prot (Q13136.1)"
     variation       450
                     /replace="t"
                     /db_xref="dbSNP:769172797"
     variation       454
                     /replace="l"
                     /db_xref="dbSNP:775005508"
     variation       458
                     /replace="c"
                     /db_xref="dbSNP:915648017"
     variation       458
                     /replace="s"
                     /db_xref="dbSNP:1347891808"
     variation       459
                     /replace="y"
                     /db_xref="dbSNP:1296075980"
     variation       461
                     /replace="r"
                     /db_xref="dbSNP:374923538"
     variation       463
                     /replace="q"
                     /db_xref="dbSNP:774155528"
     variation       463
                     /replace="r"
                     /db_xref="dbSNP:763697372"
     variation       464
                     /replace="f"
                     /db_xref="dbSNP:761573726"
     variation       467
                     /replace="i"
                     /db_xref="dbSNP:750326964"
     variation       468
                     /replace="e"
                     /db_xref="dbSNP:755147763"
     variation       468
                     /replace="k"
                     /db_xref="dbSNP:1423808479"
     variation       469
                     /replace="r"
                     /db_xref="dbSNP:150603415"
     variation       471
                     /replace="v"
                     /db_xref="dbSNP:996894753"
     variation       472
                     /replace="g"
                     /db_xref="dbSNP:752760884"
     variation       473
                     /replace="f"
                     /db_xref="dbSNP:758712657"
     variation       474
                     /replace="e"
                     /db_xref="dbSNP:374359436"
     variation       475
                     /replace="d"
                     /db_xref="dbSNP:1049420364"
     variation       475
                     /replace="h"
                     /db_xref="dbSNP:778114663"
     variation       477
                     /replace="t"
                     /db_xref="dbSNP:1449458760"
     variation       478
                     /replace="c"
                     /db_xref="dbSNP:1303299451"
     variation       479
                     /replace="i"
                     /db_xref="dbSNP:756603005"
     variation       480
                     /replace="v"
                     /db_xref="dbSNP:1221352934"
     variation       483
                     /replace="a"
                     /db_xref="dbSNP:780518016"
     variation       485
                     /replace="r"
                     /db_xref="dbSNP:748836936"
     variation       485
                     /replace="r"
                     /db_xref="dbSNP:768151163"
     variation       489
                     /replace="a"
                     /db_xref="dbSNP:752908891"
     variation       489
                     /replace="p"
                     /db_xref="dbSNP:201064312"
     variation       492
                     /replace="g"
                     /db_xref="dbSNP:17857002"
     variation       495
                     /replace="h"
                     /db_xref="dbSNP:199853206"
     variation       496
                     /replace="n"
                     /db_xref="dbSNP:771691335"
     variation       497
                     /replace="k"
                     /db_xref="dbSNP:76091062"
     variation       498
                     /replace="e"
                     /db_xref="dbSNP:1486352256"
     variation       498
                     /replace="g"
                     /db_xref="dbSNP:1264924750"
     variation       498
                     /replace="n"
                     /db_xref="dbSNP:747658786"
     variation       499
                     /replace="h"
                     /db_xref="dbSNP:758032676"
     variation       501
                     /replace="f"
                     /db_xref="dbSNP:1246013851"
     variation       503
                     /replace="i"
                     /db_xref="dbSNP:777446727"
     variation       504
                     /replace="m"
                     /db_xref="dbSNP:770833301"
     variation       504
                     /replace="n"
                     /db_xref="dbSNP:746844355"
     variation       505
                     /replace="e"
                     /db_xref="dbSNP:776510315"
     variation       506
                     /replace="v"
                     /db_xref="dbSNP:1163534410"
     variation       507
                     /replace="v"
                     /db_xref="dbSNP:1345266791"
     variation       508
                     /replace="k"
                     /db_xref="dbSNP:144640710"
     variation       512
                     /replace="d"
                     /db_xref="dbSNP:774316313"
     variation       513
                     /replace="d"
                     /db_xref="dbSNP:1363494007"
     variation       513
                     /replace="l"
                     /db_xref="dbSNP:200380573"
     variation       514
                     /replace="i"
                     /db_xref="dbSNP:773480881"
     variation       514
                     /replace="v"
                     /db_xref="dbSNP:767673660"
     variation       517
                     /replace="g"
                     /db_xref="dbSNP:772581748"
     variation       519
                     /replace="s"
                     /db_xref="dbSNP:766746363"
     variation       521
                     /replace="v"
                     /db_xref="dbSNP:754137054"
     variation       522
                     /replace="r"
                     /db_xref="dbSNP:1042331147"
     variation       523
                     /replace="d"
                     /db_xref="dbSNP:755513780"
     variation       523
                     /replace="q"
                     /db_xref="dbSNP:775891962"
     variation       524
                     /replace="g"
                     /db_xref="dbSNP:765726553"
     variation       524
                     /replace="s"
                     /db_xref="dbSNP:1464278702"
     variation       525
                     /replace="p"
                     /db_xref="dbSNP:149790526"
     variation       525
                     /replace="r"
                     /db_xref="dbSNP:144561273"
     variation       526
                     /replace="l"
                     /db_xref="dbSNP:763308663"
     variation       526
                     /replace="t"
                     /db_xref="dbSNP:1480581888"
     variation       527
                     /replace="h"
                     /db_xref="dbSNP:763663821"
     variation       529
                     /replace="a"
                     /db_xref="dbSNP:750991790"
     variation       529
                     /replace="g"
                     /db_xref="dbSNP:1009201762"
     variation       529
                     /replace="s"
                     /db_xref="dbSNP:1336610763"
     variation       532
                     /replace="a"
                     /db_xref="dbSNP:756992423"
     variation       537
                     /replace="l"
                     /db_xref="dbSNP:780969851"
     variation       538
                     /replace="t"
                     /db_xref="dbSNP:1306333971"
     variation       538
                     /replace="v"
                     /db_xref="dbSNP:750284888"
     variation       540
                     /replace="d"
                     /db_xref="dbSNP:1061328"
     variation       541
                     /replace="c"
                     /db_xref="dbSNP:749263889"
     variation       541
                     /replace="g"
                     /db_xref="dbSNP:768414277"
     variation       543
                     /replace="r"
                     /db_xref="dbSNP:1276783101"
     variation       543
                     /replace="t"
                     /db_xref="dbSNP:777942431"
     variation       546
                     /replace="-"
                     /db_xref="dbSNP:1242346091"
     variation       546
                     /replace="y"
                     /db_xref="dbSNP:557872911"
     variation       547
                     /replace="n"
                     /db_xref="dbSNP:1273427149"
     variation       547
                     /replace="s"
                     /db_xref="dbSNP:1181661504"
     variation       549
                     /replace="r"
                     /db_xref="dbSNP:776826221"
     variation       549
                     /replace="t"
                     /db_xref="dbSNP:771195635"
     variation       550
                     /replace="t"
                     /db_xref="dbSNP:759948326"
     variation       550
                     /replace="v"
                     /db_xref="dbSNP:770205462"
     variation       551
                     /replace="m"
                     /db_xref="dbSNP:981588311"
     variation       552
                     /replace="l"
                     /db_xref="dbSNP:775648303"
     variation       552
                     /replace="r"
                     /db_xref="dbSNP:1459041003"
     variation       553
                     /replace="g"
                     /db_xref="dbSNP:1252672946"
     variation       553
                     /replace="l"
                     /db_xref="dbSNP:763545367"
     variation       554
                     /replace="c"
                     /db_xref="dbSNP:764459505"
     variation       554
                     /replace="h"
                     /db_xref="dbSNP:370268058"
     variation       555
                     /replace="t"
                     /db_xref="dbSNP:17853269"
     variation       557
                     /replace="k"
                     /db_xref="dbSNP:1049203932"
     variation       557
                     /replace="r"
                     /db_xref="dbSNP:145318201"
     variation       558
                     /replace="r"
                     /db_xref="dbSNP:147640495"
     variation       559
                     /replace="q"
                     /db_xref="dbSNP:750088810"
     variation       559
                     /replace="r"
                     /db_xref="dbSNP:878885316"
     variation       562
                     /replace="a"
                     /db_xref="dbSNP:1405591687"
     variation       562
                     /replace="t"
                     /db_xref="dbSNP:755665885"
     variation       563
                     /replace="l"
                     /db_xref="dbSNP:565807283"
     variation       563
                     /replace="l"
                     /db_xref="dbSNP:779907051"
     variation       564
                     /replace="l"
                     /db_xref="dbSNP:142223113"
     variation       564
                     /replace="r"
                     /db_xref="dbSNP:1436020246"
     variation       566
                     /replace="k"
                     /db_xref="dbSNP:778697942"
     variation       567
                     /replace="s"
                     /db_xref="dbSNP:747155912"
     variation       568
                     /replace="s"
                     /db_xref="dbSNP:1424982891"
     variation       571
                     /replace="q"
                     /db_xref="dbSNP:756408095"
     variation       573
                     /replace="f"
                     /db_xref="dbSNP:780108791"
     variation       573
                     /replace="p"
                     /db_xref="dbSNP:749728222"
     variation       574
                     /replace="k"
                     /db_xref="dbSNP:201379301"
     variation       577
                     /replace="d"
                     /db_xref="dbSNP:774800262"
     variation       580
                     /replace="c"
                     /db_xref="dbSNP:748672100"
     variation       580
                     /replace="h"
                     /db_xref="dbSNP:772669489"
     variation       584
                     /replace="g"
                     /db_xref="dbSNP:142065519"
     variation       585
                     /replace="g"
                     /db_xref="dbSNP:969558800"
     variation       585
                     /replace="i"
                     /db_xref="dbSNP:151134329"
     variation       585
                     /replace="s"
                     /db_xref="dbSNP:140219634"
     variation       586
                     /replace="a"
                     /db_xref="dbSNP:776130811"
     variation       588
                     /replace="v"
                     /db_xref="dbSNP:759166307"
     variation       589
                     /replace="s"
                     /db_xref="dbSNP:765017374"
     variation       590
                     /replace="g"
                     /db_xref="dbSNP:752447425"
     variation       592
                     /replace="q"
                     /db_xref="dbSNP:1181774144"
     variation       592
                     /replace="r"
                     /db_xref="dbSNP:1482089021"
     variation       593
                     /replace="a"
                     /db_xref="dbSNP:758352620"
     variation       594
                     /replace="f"
                     /db_xref="dbSNP:150317909"
     variation       594
                     /replace="s"
                     /db_xref="dbSNP:763995661"
     variation       595
                     /replace="k"
                     /db_xref="dbSNP:756143204"
     variation       596
                     /replace="g"
                     /db_xref="dbSNP:1430385041"
     variation       597
                     /replace="v"
                     /db_xref="dbSNP:374218903"
     variation       599
                     /replace="d"
                     /db_xref="dbSNP:368160512"
     variation       600
                     /replace="l"
                     /db_xref="dbSNP:138338075"
     variation       600
                     /replace="v"
                     /db_xref="dbSNP:779454180"
     variation       602
                     /replace="n"
                     /db_xref="dbSNP:1019739366"
     variation       603
                     /replace="d"
                     /db_xref="dbSNP:1255825344"
     variation       603
                     /replace="s"
                     /db_xref="dbSNP:565971727"
     variation       605
                     /replace="d"
                     /db_xref="dbSNP:371670771"
     variation       608
                     /replace="d"
                     /db_xref="dbSNP:773827445"
     variation       609
                     /replace="a"
                     /db_xref="dbSNP:146858711"
     variation       609
                     /replace="i"
                     /db_xref="dbSNP:1292539434"
     variation       610
                     /replace="f"
                     /db_xref="dbSNP:770356266"
     variation       610
                     /replace="l"
                     /db_xref="dbSNP:776136532"
     variation       610
                     /replace="p"
                     /db_xref="dbSNP:1277352900"
     variation       611
                     /replace="l"
                     /db_xref="dbSNP:867683047"
     variation       611
                     /replace="v"
                     /db_xref="dbSNP:1204453030"
     variation       614
                     /replace="i"
                     /db_xref="dbSNP:769385938"
     variation       614
                     /replace="v"
                     /db_xref="dbSNP:1451760406"
     variation       615
                     /replace="d"
                     /db_xref="dbSNP:1189669595"
     variation       616
                     /replace="l"
                     /db_xref="dbSNP:775310445"
     variation       616
                     /replace="q"
                     /db_xref="dbSNP:762703496"
     variation       617
                     /replace="l"
                     /db_xref="dbSNP:145921616"
     variation       617
                     /replace="l"
                     /db_xref="dbSNP:17160805"
     variation       617
                     /replace="q"
                     /db_xref="dbSNP:375990035"
     variation       618
                     /replace="l"
                     /db_xref="dbSNP:1164941964"
     variation       618
                     /replace="s"
                     /db_xref="dbSNP:138482854"
     variation       620
                     /replace="s"
                     /db_xref="dbSNP:753917448"
     variation       621
                     /replace="e"
                     /db_xref="dbSNP:779259044"
     variation       621
                     /replace="r"
                     /db_xref="dbSNP:755275955"
     variation       623
                     /replace="a"
                     /db_xref="dbSNP:149630964"
     variation       624
                     /replace="d"
                     /db_xref="dbSNP:3740717"
     variation       624
                     /replace="n"
                     /db_xref="dbSNP:143247748"
     variation       625
                     /replace="a"
                     /db_xref="dbSNP:745358718"
     variation       625
                     /replace="s"
                     /db_xref="dbSNP:148292877"
     variation       625
                     /replace="v"
                     /db_xref="dbSNP:780588118"
     variation       626
                     /replace="r"
                     /db_xref="dbSNP:1236282143"
     variation       628
                     /replace="l"
                     /db_xref="dbSNP:775117760"
     variation       629
                     /replace="a"
                     /db_xref="dbSNP:762795108"
     variation       630
                     /replace="t"
                     /db_xref="dbSNP:1359501044"
     variation       631
                     /replace="-"
                     /db_xref="dbSNP:1215188807"
     variation       631
                     /replace="i"
                     /db_xref="dbSNP:1272348908"
     variation       633
                     /replace="r"
                     /db_xref="dbSNP:1242387912"
     variation       635
                     /replace="r"
                     /db_xref="dbSNP:774129879"
     variation       637
                     /replace="d"
                     /db_xref="dbSNP:556328141"
     variation       638
                     /replace="t"
                     /db_xref="dbSNP:767442340"
     variation       640
                     /replace="i"
                     /db_xref="dbSNP:753916364"
     variation       640
                     /replace="n"
                     /db_xref="dbSNP:1446683615"
     variation       641
                     /replace="e"
                     /db_xref="dbSNP:765625381"
     variation       642
                     /replace="q"
                     /db_xref="dbSNP:752958955"
     variation       645
                     /replace="f"
                     /db_xref="dbSNP:1367347790"
     variation       647
                     /replace="q"
                     /db_xref="dbSNP:1285346806"
     variation       653
                     /replace="k"
                     /db_xref="dbSNP:767937636"
     variation       656
                     /replace="q"
                     /db_xref="dbSNP:766838458"
     variation       656
                     /replace="w"
                     /db_xref="dbSNP:141485507"
     variation       657
                     /replace="a"
                     /db_xref="dbSNP:150848472"
     variation       657
                     /replace="t"
                     /db_xref="dbSNP:753392564"
     variation       661
                     /replace="q"
                     /db_xref="dbSNP:867906957"
     variation       662
                     /replace="r"
                     /db_xref="dbSNP:139710564"
     variation       663
                     /replace="g"
                     /db_xref="dbSNP:1369637457"
     variation       663
                     /replace="q"
                     /db_xref="dbSNP:778493654"
     variation       665
                     /replace="a"
                     /db_xref="dbSNP:757943023"
     variation       665
                     /replace="s"
                     /db_xref="dbSNP:747838106"
     Site            666
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q13136.1)"
     variation       667
                     /replace="r"
                     /db_xref="dbSNP:1466673186"
     variation       668
                     /replace="r"
                     /db_xref="dbSNP:375771367"
     Site            668
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (Q13136.1)"
     variation       669
                     /replace="i"
                     /db_xref="dbSNP:1181170553"
     variation       669
                     /replace="l"
                     /db_xref="dbSNP:777745652"
     variation       670
                     /replace="d"
                     /db_xref="dbSNP:1473146007"
     variation       670
                     /replace="g"
                     /db_xref="dbSNP:200071935"
     variation       671
                     /replace="n"
                     /db_xref="dbSNP:1483500938"
     variation       671
                     /replace="s"
                     /db_xref="dbSNP:771043827"
     variation       674
                     /replace="c"
                     /db_xref="dbSNP:781264680"
     variation       674
                     /replace="h"
                     /db_xref="dbSNP:749396415"
     variation       675
                     /replace="c"
                     /db_xref="dbSNP:768787607"
     variation       676
                     /replace="s"
                     /db_xref="dbSNP:1390537565"
     variation       678
                     /replace="v"
                     /db_xref="dbSNP:113293089"
     variation       679
                     /replace="s"
                     /db_xref="dbSNP:1040461185"
     variation       680
                     /replace="c"
                     /db_xref="dbSNP:762117250"
     variation       681
                     /replace="si"
                     /db_xref="dbSNP:1317502668"
     variation       682
                     /replace="s"
                     /db_xref="dbSNP:773605824"
     variation       683
                     /replace="a"
                     /db_xref="dbSNP:761003247"
     variation       683
                     /replace="h"
                     /db_xref="dbSNP:147181972"
     variation       685
                     /replace="l"
                     /db_xref="dbSNP:1269221095"
     variation       685
                     /replace="s"
                     /db_xref="dbSNP:1228593922"
     variation       686
                     /replace="p"
                     /db_xref="dbSNP:759890553"
     variation       688
                     /replace="l"
                     /db_xref="dbSNP:748263753"
     variation       688
                     /replace="p"
                     /db_xref="dbSNP:764813079"
     variation       688
                     /replace="s"
                     /db_xref="dbSNP:372477702"
     variation       689
                     /replace="i"
                     /db_xref="dbSNP:758113105"
     variation       690
                     /replace="d"
                     /db_xref="dbSNP:1255445517"
     variation       691
                     /replace="g"
                     /db_xref="dbSNP:1475030811"
     variation       691
                     /replace="i"
                     /db_xref="dbSNP:1403467535"
     variation       692
                     /replace="f"
                     /db_xref="dbSNP:4635110"
     variation       693
                     /replace="f"
                     /db_xref="dbSNP:963382517"
     variation       693
                     /replace="s"
                     /db_xref="dbSNP:879849838"
     Site            693
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:19690332,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q13136.1)"
     variation       694
                     /replace="l"
                     /db_xref="dbSNP:777549211"
     variation       694
                     /replace="s"
                     /db_xref="dbSNP:1413942333"
     variation       695
                     /replace="a"
                     /db_xref="dbSNP:1157943563"
     variation       695
                     /replace="l"
                     /db_xref="dbSNP:140626007"
     variation       695
                     /replace="p"
                     /db_xref="dbSNP:199713917"
     variation       696
                     /replace="d"
                     /db_xref="dbSNP:1054156319"
     variation       699
                     /replace="c"
                     /db_xref="dbSNP:1331676479"
     variation       699
                     /replace="h"
                     /db_xref="dbSNP:149738073"
     variation       700
                     /replace="c"
                     /db_xref="dbSNP:145476630"
     variation       702
                     /replace="l"
                     /db_xref="dbSNP:1013173315"
     variation       702
                     /replace="p"
                     /db_xref="dbSNP:1237405808"
     variation       702
                     /replace="s"
                     /db_xref="dbSNP:779080896"
     variation       703
                     /replace="g"
                     /db_xref="dbSNP:1022841762"
     variation       703
                     /replace="q"
                     /db_xref="dbSNP:748144424"
     variation       705
                     /replace="f"
                     /db_xref="dbSNP:772327938"
     variation       708
                     /replace="g"
                     /db_xref="dbSNP:1278312890"
     variation       709
                     /replace="a"
                     /db_xref="dbSNP:773407607"
     variation       710
                     /replace="v"
                     /db_xref="dbSNP:1183166163"
     variation       711
                     /replace="q"
                     /db_xref="dbSNP:907134523"
     variation       711
                     /replace="r"
                     /db_xref="dbSNP:747188390"
     variation       711
                     /replace="w"
                     /db_xref="dbSNP:761091237"
     variation       712
                     /replace="q"
                     /db_xref="dbSNP:376495152"
     variation       715
                     /replace="g"
                     /db_xref="dbSNP:1377958898"
     variation       715
                     /replace="i"
                     /db_xref="dbSNP:552377365"
     variation       716
                     /replace="p"
                     /db_xref="dbSNP:762541792"
     variation       716
                     /replace="r"
                     /db_xref="dbSNP:769564172"
     variation       717
                     /replace="g"
                     /db_xref="dbSNP:148399004"
     variation       718
                     /replace="i"
                     /db_xref="dbSNP:751262599"
     variation       719
                     /replace="i"
                     /db_xref="dbSNP:756912702"
     variation       720
                     /replace="t"
                     /db_xref="dbSNP:1348310911"
     variation       722
                     /replace="l"
                     /db_xref="dbSNP:1212222049"
     variation       723
                     /replace="p"
                     /db_xref="dbSNP:1183625783"
     variation       724
                     /replace="l"
                     /db_xref="dbSNP:746313866"
     variation       724
                     /replace="s"
                     /db_xref="dbSNP:781261094"
     variation       729
                     /replace="v"
                     /db_xref="dbSNP:1305453243"
     variation       731
                     /replace="e"
                     /db_xref="dbSNP:775868490"
     variation       731
                     /replace="h"
                     /db_xref="dbSNP:770059890"
     variation       732
                     /replace="n"
                     /db_xref="dbSNP:749835491"
     variation       733
                     /replace="d"
                     /db_xref="dbSNP:1483858201"
     variation       734
                     /replace="i"
                     /db_xref="dbSNP:1438182118"
     variation       736
                     /replace="v"
                     /db_xref="dbSNP:769246589"
     variation       737
                     /replace="n"
                     /db_xref="dbSNP:1361559191"
     variation       737
                     /replace="r"
                     /db_xref="dbSNP:888913628"
     variation       738
                     /replace="c"
                     /db_xref="dbSNP:760426842"
     variation       738
                     /replace="s"
                     /db_xref="dbSNP:1292454990"
     variation       740
                     /replace="a"
                     /db_xref="dbSNP:761384781"
     variation       741
                     /replace="f"
                     /db_xref="dbSNP:1231556989"
     variation       741
                     /replace="s"
                     /db_xref="dbSNP:767256422"
     variation       742
                     /replace="l"
                     /db_xref="dbSNP:532117723"
     variation       742
                     /replace="p"
                     /db_xref="dbSNP:150538251"
     variation       742
                     /replace="s"
                     /db_xref="dbSNP:1192296885"
     variation       743
                     /replace="a"
                     /db_xref="dbSNP:1173136741"
     variation       744
                     /replace="f"
                     /db_xref="dbSNP:766098300"
     variation       746
                     /replace="l"
                     /db_xref="dbSNP:1015477738"
     variation       746
                     /replace="p"
                     /db_xref="dbSNP:963595622"
     variation       747
                     /replace="r"
                     /db_xref="dbSNP:1008685716"
     variation       748
                     /replace="a"
                     /db_xref="dbSNP:754935628"
     variation       748
                     /replace="v"
                     /db_xref="dbSNP:753577052"
     variation       749
                     /replace="v"
                     /db_xref="dbSNP:565265508"
     variation       750
                     /replace="l"
                     /db_xref="dbSNP:142586381"
     variation       750
                     /replace="r"
                     /db_xref="dbSNP:376758739"
     variation       750
                     /replace="w"
                     /db_xref="dbSNP:374396970"
     variation       753
                     /replace="q"
                     /db_xref="dbSNP:370933248"
     variation       753
                     /replace="r"
                     /db_xref="dbSNP:780314303"
     variation       753
                     /replace="w"
                     /db_xref="dbSNP:184308703"
     variation       754
                     /replace="p"
                     /db_xref="dbSNP:749639299"
     variation       757
                     /replace="r"
                     /db_xref="dbSNP:769334632"
     variation       758
                     /replace="a"
                     /db_xref="dbSNP:200196757"
     variation       758
                     /replace="s"
                     /db_xref="dbSNP:779548626"
     variation       758
                     /replace="v"
                     /db_xref="dbSNP:139448605"
     variation       759
                     /replace="p"
                     /db_xref="dbSNP:1467564330"
     variation       761
                     /replace="a"
                     /db_xref="dbSNP:935212680"
     variation       761
                     /replace="t"
                     /db_xref="dbSNP:7943276"
     Site            761
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (Q13136.1)"
     variation       762
                     /replace="i"
                     /db_xref="dbSNP:149670968"
     variation       762
                     /replace="v"
                     /db_xref="dbSNP:17853270"
     Site            763
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q13136.1)"
     variation       764
                     /replace="h"
                     /db_xref="dbSNP:759317112"
     variation       765
                     /replace="-"
                     /db_xref="dbSNP:1225647381"
     variation       765
                     /replace="e"
                     /db_xref="dbSNP:1279212315"
     variation       765
                     /replace="k"
                     /db_xref="dbSNP:765227857"
     variation       766
                     /replace="a"
                     /db_xref="dbSNP:1406172639"
     variation       767
                     /replace="i"
                     /db_xref="dbSNP:1331350220"
     variation       768
                     /replace="r"
                     /db_xref="dbSNP:1166883624"
     variation       769
                     /replace="e"
                     /db_xref="dbSNP:762892289"
     variation       769
                     /replace="h"
                     /db_xref="dbSNP:752639532"
     variation       770
                     /replace="m"
                     /db_xref="dbSNP:1321062054"
     variation       771
                     /replace="r"
                     /db_xref="dbSNP:767518511"
     variation       774
                     /replace="i"
                     /db_xref="dbSNP:758864898"
     variation       774
                     /replace="t"
                     /db_xref="dbSNP:1203803555"
     variation       775
                     /replace="g"
                     /db_xref="dbSNP:778334587"
     variation       776
                     /replace="s"
                     /db_xref="dbSNP:1231048086"
     variation       778
                     /replace="d"
                     /db_xref="dbSNP:1183613976"
     variation       778
                     /replace="g"
                     /db_xref="dbSNP:746570763"
     variation       778
                     /replace="h"
                     /db_xref="dbSNP:1365301857"
     variation       779
                     /replace="g"
                     /db_xref="dbSNP:1442438158"
     variation       779
                     /replace="s"
                     /db_xref="dbSNP:1384051720"
     variation       780
                     /replace="l"
                     /db_xref="dbSNP:1402300211"
     variation       780
                     /replace="p"
                     /db_xref="dbSNP:531675653"
     variation       780
                     /replace="s"
                     /db_xref="dbSNP:756766672"
     variation       781
                     /replace="g"
                     /db_xref="dbSNP:1420735775"
     variation       781
                     /replace="m"
                     /db_xref="dbSNP:745544222"
     variation       782
                     /replace="i"
                     /db_xref="dbSNP:146597848"
     variation       782
                     /replace="s"
                     /db_xref="dbSNP:1168954700"
     variation       783
                     /replace="s"
                     /db_xref="dbSNP:1375331781"
     variation       784
                     /replace="r"
                     /db_xref="dbSNP:1308555892"
     variation       785
                     /replace="g"
                     /db_xref="dbSNP:1410024962"
     variation       786
                     /replace="g"
                     /db_xref="dbSNP:1408883929"
     variation       786
                     /replace="s"
                     /db_xref="dbSNP:1308226509"
     variation       787
                     /replace="g"
                     /db_xref="dbSNP:1337858619"
     variation       788
                     /replace="n"
                     /db_xref="dbSNP:1350614325"
     variation       788
                     /replace="s"
                     /db_xref="dbSNP:1336221814"
     variation       789
                     /replace="g"
                     /db_xref="dbSNP:775188324"
     variation       789
                     /replace="s"
                     /db_xref="dbSNP:1433235640"
     variation       790
                     /replace="s"
                     /db_xref="dbSNP:749088584"
     variation       791
                     /replace="r"
                     /db_xref="dbSNP:1349209557"
     variation       792
                     /replace="g"
                     /db_xref="dbSNP:1278242268"
     variation       792
                     /replace="n"
                     /db_xref="dbSNP:1213192217"
     variation       793
                     /replace="l"
                     /db_xref="dbSNP:768532805"
     variation       793
                     /replace="s"
                     /db_xref="dbSNP:550694136"
     variation       794
                     /replace="i"
                     /db_xref="dbSNP:1250290094"
     variation       794
                     /replace="l"
                     /db_xref="dbSNP:1213708101"
     variation       794
                     /replace="r"
                     /db_xref="dbSNP:979943168"
     variation       795
                     /replace="p"
                     /db_xref="dbSNP:1256101256"
     variation       795
                     /replace="y"
                     /db_xref="dbSNP:761586765"
     variation       796
                     /replace="k"
                     /db_xref="dbSNP:1268671989"
     variation       797
                     /replace="a"
                     /db_xref="dbSNP:1219015720"
     variation       798
                     /replace="s"
                     /db_xref="dbSNP:766578290"
     variation       800
                     /replace="r"
                     /db_xref="dbSNP:776800646"
     variation       801
                     /replace="k"
                     /db_xref="dbSNP:1325642898"
     variation       803
                     /replace="i"
                     /db_xref="dbSNP:1204186635"
     variation       807
                     /replace="i"
                     /db_xref="dbSNP:1242062438"
     variation       808
                     /replace="g"
                     /db_xref="dbSNP:1303318925"
     variation       808
                     /replace="s"
                     /db_xref="dbSNP:1440179640"
     variation       809
                     /replace="c"
                     /db_xref="dbSNP:1388528635"
     variation       809
                     /replace="r"
                     /db_xref="dbSNP:1391631879"
     variation       812
                     /replace="r"
                     /db_xref="dbSNP:1194892973"
     variation       813
                     /replace="k"
                     /db_xref="dbSNP:1456630727"
     variation       814
                     /replace="k"
                     /db_xref="dbSNP:1242268998"
     variation       817
                     /replace="g"
                     /db_xref="dbSNP:145603046"
     variation       817
                     /replace="v"
                     /db_xref="dbSNP:1054758842"
     variation       818
                     /replace="q"
                     /db_xref="dbSNP:1455531285"
     variation       818
                     /replace="r"
                     /db_xref="dbSNP:1457050276"
     variation       822
                     /replace="p"
                     /db_xref="dbSNP:201925057"
     variation       822
                     /replace="t"
                     /db_xref="dbSNP:753049351"
     variation       823
                     /replace="v"
                     /db_xref="dbSNP:1430031509"
     variation       824
                     /replace="r"
                     /db_xref="dbSNP:758790362"
     variation       826
                     /replace="a"
                     /db_xref="dbSNP:530047535"
     variation       826
                     /replace="t"
                     /db_xref="dbSNP:1399093824"
     variation       830
                     /replace="a"
                     /db_xref="dbSNP:1336585423"
     variation       830
                     /replace="d"
                     /db_xref="dbSNP:751832580"
     variation       831
                     /replace="g"
                     /db_xref="dbSNP:762348894"
     variation       832
                     /replace="v"
                     /db_xref="dbSNP:556582393"
     variation       833
                     /replace="p"
                     /db_xref="dbSNP:749993819"
     variation       833
                     /replace="s"
                     /db_xref="dbSNP:755615764"
     variation       834
                     /replace="k"
                     /db_xref="dbSNP:187027607"
     variation       835
                     /replace="m"
                     /db_xref="dbSNP:753540447"
     variation       835
                     /replace="t"
                     /db_xref="dbSNP:372351393"
     variation       836
                     /replace="g"
                     /db_xref="dbSNP:778796834"
     variation       837
                     /replace="n"
                     /db_xref="dbSNP:772180520"
     variation       841
                     /replace="h"
                     /db_xref="dbSNP:777837352"
     variation       845
                     /replace="l"
                     /db_xref="dbSNP:777350386"
     variation       848
                     /replace="f"
                     /db_xref="dbSNP:1359880961"
     variation       848
                     /replace="l"
                     /db_xref="dbSNP:769933389"
     variation       848
                     /replace="w"
                     /db_xref="dbSNP:775387061"
     variation       849
                     /replace="e"
                     /db_xref="dbSNP:1294086769"
     variation       849
                     /replace="g"
                     /db_xref="dbSNP:1415448713"
     variation       849
                     /replace="r"
                     /db_xref="dbSNP:541483000"
     variation       850
                     /replace="e"
                     /db_xref="dbSNP:762154302"
     variation       850
                     /replace="r"
                     /db_xref="dbSNP:375310513"
     variation       852
                     /replace="a"
                     /db_xref="dbSNP:768081341"
     variation       852
                     /replace="d"
                     /db_xref="dbSNP:966916811"
     variation       852
                     /replace="p"
                     /db_xref="dbSNP:1025987592"
     variation       855
                     /replace="s"
                     /db_xref="dbSNP:750933310"
     variation       856
                     /replace="h"
                     /db_xref="dbSNP:1258438687"
     variation       857
                     /replace="e"
                     /db_xref="dbSNP:761111315"
     variation       857
                     /replace="k"
                     /db_xref="dbSNP:765935116"
     variation       861
                     /replace="k"
                     /db_xref="dbSNP:1471218554"
     variation       862
                     /replace="h"
                     /db_xref="dbSNP:748301426"
     variation       862
                     /replace="y"
                     /db_xref="dbSNP:1308946267"
     variation       865
                     /replace="l"
                     /db_xref="dbSNP:770343166"
     variation       866
                     /replace="g"
                     /db_xref="dbSNP:17853271"
     variation       869
                     /replace="g"
                     /db_xref="dbSNP:201951162"
     variation       869
                     /replace="q"
                     /db_xref="dbSNP:761275496"
     variation       869
                     /replace="r"
                     /db_xref="dbSNP:1453325652"
     variation       870
                     /replace="r"
                     /db_xref="dbSNP:766761273"
     variation       872
                     /replace="d"
                     /db_xref="dbSNP:150266560"
     Region          875..945
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          875..941
                     /region_name="SAM"
                     /note="Sterile alpha motif; smart00454"
                     /db_xref="CDD:197735"
     variation       876
                     /replace="a"
                     /db_xref="dbSNP:765003842"
     variation       876
                     /replace="t"
                     /db_xref="dbSNP:139726690"
     variation       877
                     /replace="q"
                     /db_xref="dbSNP:752413559"
     variation       879
                     /replace="d"
                     /db_xref="dbSNP:111455193"
     variation       879
                     /replace="n"
                     /db_xref="dbSNP:1441526809"
     variation       880
                     /replace="r"
                     /db_xref="dbSNP:1464722210"
     variation       882
                     /replace="a"
                     /db_xref="dbSNP:764016850"
     variation       882
                     /replace="m"
                     /db_xref="dbSNP:149349390"
     variation       882
                     /replace="t"
                     /db_xref="dbSNP:1218307221"
     variation       884
                     /replace="a"
                     /db_xref="dbSNP:780978665"
     variation       884
                     /replace="m"
                     /db_xref="dbSNP:757268427"
     variation       885
                     /replace="i"
                     /db_xref="dbSNP:749453150"
     variation       887
                     /replace="l"
                     /db_xref="dbSNP:763262863"
     variation       889
                     /replace="v"
                     /db_xref="dbSNP:748194805"
     variation       890
                     /replace="c"
                     /db_xref="dbSNP:777954879"
     variation       890
                     /replace="r"
                     /db_xref="dbSNP:530179068"
     variation       890
                     /replace="s"
                     /db_xref="dbSNP:1318425948"
     variation       892
                     /replace="v"
                     /db_xref="dbSNP:12829"
     variation       895
                     /replace="t"
                     /db_xref="dbSNP:747470946"
     variation       895
                     /replace="v"
                     /db_xref="dbSNP:375004396"
     variation       897
                     /replace="y"
                     /db_xref="dbSNP:781575330"
     variation       898
                     /replace="a"
                     /db_xref="dbSNP:746396602"
     variation       899
                     /replace="g"
                     /db_xref="dbSNP:928691753"
     variation       901
                     /replace="c"
                     /db_xref="dbSNP:770397955"
     variation       902
                     /replace="q"
                     /db_xref="dbSNP:1209704268"
     variation       902
                     /replace="r"
                     /db_xref="dbSNP:775192688"
     variation       904
                     /replace="n"
                     /db_xref="dbSNP:1285048270"
     variation       907
                     /replace="s"
                     /db_xref="dbSNP:199727700"
     variation       908
                     /replace="g"
                     /db_xref="dbSNP:1214747817"
     variation       910
                     /replace="v"
                     /db_xref="dbSNP:768490757"
     variation       911
                     /replace="l"
                     /db_xref="dbSNP:960105575"
     variation       911
                     /replace="t"
                     /db_xref="dbSNP:972799705"
     variation       912
                     /replace="*"
                     /db_xref="dbSNP:200102101"
     variation       912
                     /replace="s"
                     /db_xref="dbSNP:993610403"
     variation       913
                     /replace="a"
                     /db_xref="dbSNP:566685349"
     variation       914
                     /replace="l"
                     /db_xref="dbSNP:1348932786"
     variation       914
                     /replace="m"
                     /db_xref="dbSNP:1028047773"
     variation       915
                     /replace="s"
                     /db_xref="dbSNP:147023636"
     variation       916
                     /replace="n"
                     /db_xref="dbSNP:750191381"
     variation       919
                     /replace="l"
                     /db_xref="dbSNP:760645629"
     variation       921
                     /replace="h"
                     /db_xref="dbSNP:1375753525"
     variation       921
                     /replace="s"
                     /db_xref="dbSNP:1297009052"
     variation       922
                     /replace="a"
                     /db_xref="dbSNP:1416229708"
     variation       924
                     /replace="g"
                     /db_xref="dbSNP:766281671"
     variation       925
                     /replace="m"
                     /db_xref="dbSNP:1425736865"
     variation       926
                     /replace="t"
                     /db_xref="dbSNP:752829584"
     variation       927
                     /replace="i"
                     /db_xref="dbSNP:758463797"
     variation       927
                     /replace="y"
                     /db_xref="dbSNP:1161935987"
     variation       928
                     /replace="p"
                     /db_xref="dbSNP:1008214319"
     variation       929
                     /replace="l"
                     /db_xref="dbSNP:1280595944"
     variation       929
                     /replace="q"
                     /db_xref="dbSNP:757462723"
     variation       931
                     /replace="g"
                     /db_xref="dbSNP:1363810360"
     variation       931
                     /replace="k"
                     /db_xref="dbSNP:141190011"
     variation       935
                     /replace="r"
                     /db_xref="dbSNP:746224320"
     variation       935
                     /replace="r"
                     /db_xref="dbSNP:770481833"
     variation       937
                     /replace="g"
                     /db_xref="dbSNP:1017905922"
     variation       937
                     /replace="t"
                     /db_xref="dbSNP:868313093"
     variation       938
                     /replace="t"
                     /db_xref="dbSNP:1180544088"
     variation       939
                     /replace="r"
                     /db_xref="dbSNP:1213209170"
     variation       940
                     /replace="d"
                     /db_xref="dbSNP:780702280"
     variation       941
                     /replace="s"
                     /db_xref="dbSNP:1471404364"
     variation       942
                     /replace="t"
                     /db_xref="dbSNP:749747481"
     variation       943
                     /replace="s"
                     /db_xref="dbSNP:966284236"
     variation       944
                     /replace="l"
                     /db_xref="dbSNP:976213456"
     variation       944
                     /replace="m"
                     /db_xref="dbSNP:1182233221"
     variation       944
                     /replace="p"
                     /db_xref="dbSNP:768296527"
     variation       944
                     /replace="r"
                     /db_xref="dbSNP:931499743"
     variation       945
                     /replace="t"
                     /db_xref="dbSNP:1329442359"
     variation       946
                     /replace="g"
                     /db_xref="dbSNP:1437745396"
     variation       946
                     /replace="s"
                     /db_xref="dbSNP:773861035"
     variation       947
                     /replace="a"
                     /db_xref="dbSNP:761400948"
     variation       947
                     /replace="l"
                     /db_xref="dbSNP:771724048"
     variation       947
                     /replace="p"
                     /db_xref="dbSNP:181643615"
     variation       949
                     /replace="d"
                     /db_xref="dbSNP:1395857183"
     variation       949
                     /replace="s"
                     /db_xref="dbSNP:1400539599"
     variation       950
                     /replace="l"
                     /db_xref="dbSNP:201742446"
     variation       950
                     /replace="p"
                     /db_xref="dbSNP:138402193"
     variation       950
                     /replace="s"
                     /db_xref="dbSNP:760445433"
     variation       951
                     /replace="l"
                     /db_xref="dbSNP:1308635925"
     variation       952
                     /replace="a"
                     /db_xref="dbSNP:1322000875"
     variation       954
                     /replace="g"
                     /db_xref="dbSNP:1348636940"
     variation       955
                     /replace="m"
                     /db_xref="dbSNP:143895504"
     variation       956
                     /replace="a"
                     /db_xref="dbSNP:147198550"
     variation       956
                     /replace="i"
                     /db_xref="dbSNP:150101926"
     variation       956
                     /replace="t"
                     /db_xref="dbSNP:112958017"
     variation       957
                     /replace="f"
                     /db_xref="dbSNP:1215343566"
     variation       957
                     /replace="l"
                     /db_xref="dbSNP:775502696"
     variation       957
                     /replace="p"
                     /db_xref="dbSNP:769690451"
     variation       958
                     /replace="a"
                     /db_xref="dbSNP:1232544010"
     variation       958
                     /replace="p"
                     /db_xref="dbSNP:140483365"
     variation       959
                     /replace="c"
                     /db_xref="dbSNP:773387801"
     variation       959
                     /replace="n"
                     /db_xref="dbSNP:190661944"
     variation       960
                     /replace="e"
                     /db_xref="dbSNP:1434925282"
     variation       960
                     /replace="w"
                     /db_xref="dbSNP:761016829"
     variation       961
                     /replace="g"
                     /db_xref="dbSNP:932457258"
     variation       961
                     /replace="y"
                     /db_xref="dbSNP:1317856169"
     Region          962..1027
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     variation       962
                     /replace="t"
                     /db_xref="dbSNP:1304030164"
     variation       963
                     /replace="s"
                     /db_xref="dbSNP:751253424"
     variation       964
                     /replace="h"
                     /db_xref="dbSNP:115304320"
     variation       965
                     /replace="k"
                     /db_xref="dbSNP:754312016"
     variation       967
                     /replace="i"
                     /db_xref="dbSNP:755366130"
     variation       967
                     /replace="v"
                     /db_xref="dbSNP:1358186776"
     variation       968
                     /replace="s"
                     /db_xref="dbSNP:765449768"
     variation       969
                     /replace="n"
                     /db_xref="dbSNP:150795805"
     Region          970..1025
                     /region_name="SAM"
                     /note="Sterile alpha motif; smart00454"
                     /db_xref="CDD:197735"
     variation       970
                     /replace="d"
                     /db_xref="dbSNP:1191308041"
     variation       970
                     /replace="k"
                     /db_xref="dbSNP:754393522"
     variation       972
                     /replace="l"
                     /db_xref="dbSNP:1422576299"
     variation       973
                     /replace="l"
                     /db_xref="dbSNP:1475495318"
     variation       974
                     /replace="s"
                     /db_xref="dbSNP:777293078"
     variation       975
                     /replace="l"
                     /db_xref="dbSNP:751050245"
     variation       977
                     /replace="l"
                     /db_xref="dbSNP:1404288094"
     variation       978
                     /replace="l"
                     /db_xref="dbSNP:1362132616"
     variation       978
                     /replace="s"
                     /db_xref="dbSNP:756964774"
     variation       979
                     /replace="e"
                     /db_xref="dbSNP:780822312"
     variation       979
                     /replace="r"
                     /db_xref="dbSNP:1296743703"
     variation       981
                     /replace="h"
                     /db_xref="dbSNP:371651040"
     variation       983
                     /replace="c"
                     /db_xref="dbSNP:769646081"
     variation       983
                     /replace="n"
                     /db_xref="dbSNP:745445450"
     variation       983
                     /replace="y"
                     /db_xref="dbSNP:139065454"
     variation       986
                     /replace="e"
                     /db_xref="dbSNP:1354823335"
     variation       987
                     /replace="c"
                     /db_xref="dbSNP:267603161"
     variation       987
                     /replace="y"
                     /db_xref="dbSNP:749280540"
     variation       990
                     /replace="d"
                     /db_xref="dbSNP:768444929"
     variation       991
                     /replace="s"
                     /db_xref="dbSNP:760824140"
     variation       991
                     /replace="v"
                     /db_xref="dbSNP:549513152"
     variation       992
                     /replace="g"
                     /db_xref="dbSNP:1000846667"
     variation       992
                     /replace="s"
                     /db_xref="dbSNP:996610347"
     variation       993
                     /replace="t"
                     /db_xref="dbSNP:1189325443"
     variation       993
                     /replace="v"
                     /db_xref="dbSNP:1028528587"
     variation       995
                     /replace="d"
                     /db_xref="dbSNP:955142528"
     variation       995
                     /replace="n"
                     /db_xref="dbSNP:1235734603"
     variation       996
                     /replace="n"
                     /db_xref="dbSNP:1472421200"
     variation       998
                     /replace="p"
                     /db_xref="dbSNP:1315493672"
     variation       999
                     /replace="n"
                     /db_xref="dbSNP:1381556574"
     variation       999
                     /replace="r"
                     /db_xref="dbSNP:759615003"
     variation       1000
                     /replace="k"
                     /db_xref="dbSNP:1031275970"
     variation       1000
                     /replace="q"
                     /db_xref="dbSNP:1417517494"
     variation       1000
                     /replace="r"
                     /db_xref="dbSNP:1157626074"
     variation       1001
                     /replace="g"
                     /db_xref="dbSNP:765652511"
     variation       1001
                     /replace="t"
                     /db_xref="dbSNP:1426976388"
     variation       1002
                     /replace="f"
                     /db_xref="dbSNP:752961607"
     variation       1002
                     /replace="l"
                     /db_xref="dbSNP:763566088"
     variation       1003
                     /replace="g"
                     /db_xref="dbSNP:201453636"
     variation       1003
                     /replace="p"
                     /db_xref="dbSNP:1339285192"
     variation       1003
                     /replace="r"
                     /db_xref="dbSNP:764574554"
     variation       1004
                     /replace="e"
                     /db_xref="dbSNP:1431188951"
     variation       1004
                     /replace="g"
                     /db_xref="dbSNP:149879959"
     variation       1006
                     /replace="l"
                     /db_xref="dbSNP:11236038"
     variation       1007
                     /replace="k"
                     /db_xref="dbSNP:756768650"
     variation       1008
                     /replace="v"
                     /db_xref="dbSNP:1460321905"
     variation       1009
                     /replace="v"
                     /db_xref="dbSNP:767145487"
     variation       1010
                     /replace="g"
                     /db_xref="dbSNP:1423180490"
     variation       1010
                     /replace="n"
                     /db_xref="dbSNP:752611402"
     variation       1011
                     /replace="n"
                     /db_xref="dbSNP:1345975848"
     variation       1013
                     /replace="h"
                     /db_xref="dbSNP:1185928015"
     variation       1013
                     /replace="p"
                     /db_xref="dbSNP:750113798"
     variation       1014
                     /replace="g"
                     /db_xref="dbSNP:199839057"
     variation       1014
                     /replace="k"
                     /db_xref="dbSNP:779941815"
     variation       1015
                     /replace="d"
                     /db_xref="dbSNP:1199017285"
     variation       1017
                     /replace="f"
                     /db_xref="dbSNP:372415022"
     variation       1018
                     /replace="q"
                     /db_xref="dbSNP:1259964869"
     variation       1019
                     /replace="r"
                     /db_xref="dbSNP:1456382628"
     variation       1022
                     /replace="l"
                     /db_xref="dbSNP:763226106"
     variation       1023
                     /replace="y"
                     /db_xref="dbSNP:752073722"
     variation       1025
                     /replace="r"
                     /db_xref="dbSNP:373403571"
     variation       1026
                     /replace="w"
                     /db_xref="dbSNP:375948131"
     variation       1027
                     /replace="i"
                     /db_xref="dbSNP:1210829382"
     variation       1028
                     /replace="h"
                     /db_xref="dbSNP:749871604"
     variation       1028
                     /replace="k"
                     /db_xref="dbSNP:1171791720"
     variation       1028
                     /replace="s"
                     /db_xref="dbSNP:146411327"
     variation       1029
                     /replace="c"
                     /db_xref="dbSNP:765932463"
     variation       1030
                     /replace="d"
                     /db_xref="dbSNP:1464472374"
     variation       1031
                     /replace="q"
                     /db_xref="dbSNP:754825169"
     variation       1031
                     /replace="w"
                     /db_xref="dbSNP:377324495"
     variation       1032
                     /replace="n"
                     /db_xref="dbSNP:139875810"
     variation       1034
                     /replace="l"
                     /db_xref="dbSNP:919665558"
     variation       1034
                     /replace="p"
                     /db_xref="dbSNP:1321885777"
     variation       1036
                     /replace="g"
                     /db_xref="dbSNP:1330713195"
     variation       1038
                     /replace="k"
                     /db_xref="dbSNP:748118259"
     variation       1039
                     /replace="q"
                     /db_xref="dbSNP:1236363352"
     variation       1041
                     /replace="g"
                     /db_xref="dbSNP:578217206"
     variation       1041
                     /replace="n"
                     /db_xref="dbSNP:1332485215"
     variation       1045
                     /replace="r"
                     /db_xref="dbSNP:932429743"
     Region          1047..1118
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     variation       1047
                     /replace="d"
                     /db_xref="dbSNP:143244039"
     variation       1047
                     /replace="g"
                     /db_xref="dbSNP:944574240"
     variation       1047
                     /replace="n"
                     /db_xref="dbSNP:758369593"
     Region          1048..1118
                     /region_name="SAM"
                     /note="Sterile alpha motif; smart00454"
                     /db_xref="CDD:197735"
     variation       1048
                     /replace="l"
                     /db_xref="dbSNP:746898657"
     variation       1050
                     /replace="l"
                     /db_xref="dbSNP:780133063"
     variation       1052
                     /replace="g"
                     /db_xref="dbSNP:749546767"
     variation       1053
                     /replace="n"
                     /db_xref="dbSNP:1384610058"
     variation       1055
                     /replace="g"
                     /db_xref="dbSNP:1420567908"
     variation       1055
                     /replace="q"
                     /db_xref="dbSNP:768838414"
     variation       1056
                     /replace="m"
                     /db_xref="dbSNP:1358835141"
     variation       1058
                     /replace="c"
                     /db_xref="dbSNP:774749536"
     variation       1058
                     /replace="h"
                     /db_xref="dbSNP:772700309"
     variation       1058
                     /replace="r"
                     /db_xref="dbSNP:773592905"
     variation       1060
                     /replace="i"
                     /db_xref="dbSNP:765828707"
     variation       1060
                     /replace="l"
                     /db_xref="dbSNP:761181753"
     variation       1063
                     /replace="t"
                     /db_xref="dbSNP:759301125"
     variation       1063
                     /replace="v"
                     /db_xref="dbSNP:1411029962"
     variation       1064
                     /replace="g"
                     /db_xref="dbSNP:764959408"
     variation       1065
                     /replace="l"
                     /db_xref="dbSNP:922713008"
     variation       1068
                     /replace="f"
                     /db_xref="dbSNP:946111792"
     variation       1069
                     /replace="a"
                     /db_xref="dbSNP:752607712"
     variation       1069
                     /replace="v"
                     /db_xref="dbSNP:1418179923"
     variation       1070
                     /replace="d"
                     /db_xref="dbSNP:146616671"
     variation       1071
                     /replace="s"
                     /db_xref="dbSNP:763892087"
     variation       1071
                     /replace="y"
                     /db_xref="dbSNP:897680679"
     variation       1072
                     /replace="f"
                     /db_xref="dbSNP:11236045"
     variation       1073
                     /replace="k"
                     /db_xref="dbSNP:149188477"
     variation       1073
                     /replace="v"
                     /db_xref="dbSNP:751474660"
     variation       1074
                     /replace="k"
                     /db_xref="dbSNP:1242628750"
     variation       1075
                     /replace="s"
                     /db_xref="dbSNP:764931404"
     variation       1078
                     /replace="h"
                     /db_xref="dbSNP:142482070"
     variation       1081
                     /replace="f"
                     /db_xref="dbSNP:1024457838"
     variation       1081
                     /replace="l"
                     /db_xref="dbSNP:1337210177"
     variation       1082
                     /replace="l"
                     /db_xref="dbSNP:11236046"
     variation       1082
                     /replace="l"
                     /db_xref="dbSNP:373783497"
     variation       1083
                     /replace="a"
                     /db_xref="dbSNP:151326607"
     variation       1084
                     /replace="-"
                     /db_xref="dbSNP:1227969578"
     variation       1084
                     /replace="l"
                     /db_xref="dbSNP:779100260"
     variation       1084
                     /replace="s"
                     /db_xref="dbSNP:765895097"
     variation       1087
                     /replace="i"
                     /db_xref="dbSNP:748299324"
     variation       1088
                     /replace="f"
                     /db_xref="dbSNP:778146650"
     variation       1088
                     /replace="l"
                     /db_xref="dbSNP:772332744"
     variation       1089
                     /replace="n"
                     /db_xref="dbSNP:747502376"
     variation       1090
                     /replace="f"
                     /db_xref="dbSNP:377513159"
     variation       1091
                     /replace="s"
                     /db_xref="dbSNP:776328290"
     variation       1092
                     /replace="a"
                     /db_xref="dbSNP:140582605"
     variation       1092
                     /replace="v"
                     /db_xref="dbSNP:759101873"
     variation       1093
                     /replace="v"
                     /db_xref="dbSNP:775297296"
     variation       1095
                     /replace="l"
                     /db_xref="dbSNP:755207984"
     variation       1096
                     /replace="l"
                     /db_xref="dbSNP:763827399"
     variation       1100
                     /replace="p"
                     /db_xref="dbSNP:17853272"
     variation       1100
                     /replace="s"
                     /db_xref="dbSNP:956189092"
     variation       1101
                     /replace="m"
                     /db_xref="dbSNP:138268030"
     variation       1101
                     /replace="t"
                     /db_xref="dbSNP:767431245"
     variation       1104
                     /replace="i"
                     /db_xref="dbSNP:1365124636"
     variation       1107
                     /replace="c"
                     /db_xref="dbSNP:1263553311"
     variation       1107
                     /replace="c"
                     /db_xref="dbSNP:374441977"
     variation       1107
                     /replace="h"
                     /db_xref="dbSNP:142464353"
     variation       1107
                     /replace="i"
                     /db_xref="dbSNP:1198441180"
     variation       1107
                     /replace="r"
                     /db_xref="dbSNP:765327851"
     variation       1108
                     /replace="t"
                     /db_xref="dbSNP:752790488"
     variation       1110
                     /replace="f"
                     /db_xref="dbSNP:1323089744"
     variation       1111
                     /replace="d"
                     /db_xref="dbSNP:758596861"
     variation       1111
                     /replace="g"
                     /db_xref="dbSNP:1166285723"
     variation       1113
                     /replace="*"
                     /db_xref="dbSNP:764363017"
     variation       1114
                     /replace="l"
                     /db_xref="dbSNP:1188705106"
     variation       1116
                     /replace="k"
                     /db_xref="dbSNP:1261425875"
     variation       1116
                     /replace="t"
                     /db_xref="dbSNP:1420628655"
     variation       1117
                     /replace="l"
                     /db_xref="dbSNP:146522399"
     variation       1118
                     /replace="l"
                     /db_xref="dbSNP:1268974436"
     variation       1118
                     /replace="l"
                     /db_xref="dbSNP:1341467438"
     variation       1118
                     /replace="w"
                     /db_xref="dbSNP:1402215779"
     variation       1119
                     /replace="a"
                     /db_xref="dbSNP:757711467"
     variation       1120
                     /replace="l"
                     /db_xref="dbSNP:781650105"
     variation       1121
                     /replace="g"
                     /db_xref="dbSNP:746409569"
     variation       1121
                     /replace="r"
                     /db_xref="dbSNP:1292048563"
     variation       1122
                     /replace="p"
                     /db_xref="dbSNP:756659057"
     variation       1122
                     /replace="s"
                     /db_xref="dbSNP:1263657126"
     variation       1123
                     /replace="d"
                     /db_xref="dbSNP:748821982"
     variation       1123
                     /replace="g"
                     /db_xref="dbSNP:779763702"
     variation       1124
                     /replace="g"
                     /db_xref="dbSNP:768262846"
     variation       1124
                     /replace="t"
                     /db_xref="dbSNP:1241513650"
     variation       1125
                     /replace="-"
                     /db_xref="dbSNP:1342835899"
     variation       1125
                     /replace="k"
                     /db_xref="dbSNP:995953384"
     variation       1125
                     /replace="s"
                     /db_xref="dbSNP:774054292"
     variation       1129
                     /replace="n"
                     /db_xref="dbSNP:371497911"
     variation       1130
                     /replace="d"
                     /db_xref="dbSNP:749694662"
     variation       1131
                     /replace="n"
                     /db_xref="dbSNP:1325108363"
     Site            1133
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q13136.1)"
     variation       1135
                     /replace="r"
                     /db_xref="dbSNP:777822253"
     variation       1136
                     /replace="k"
                     /db_xref="dbSNP:1310059797"
     variation       1139
                     /replace="l"
                     /db_xref="dbSNP:1379410982"
     variation       1142
                     /replace="e"
                     /db_xref="dbSNP:772772815"
     variation       1142
                     /replace="r"
                     /db_xref="dbSNP:778234301"
     variation       1143
                     /replace="m"
                     /db_xref="dbSNP:1345514814"
     variation       1143
                     /replace="n"
                     /db_xref="dbSNP:1055932267"
     variation       1144
                     /replace="f"
                     /db_xref="dbSNP:747862011"
     variation       1145
                     /replace="g"
                     /db_xref="dbSNP:771678024"
     variation       1148
                     /replace="d"
                     /db_xref="dbSNP:915693018"
     variation       1148
                     /replace="n"
                     /db_xref="dbSNP:773039303"
     variation       1150
                     /replace="h"
                     /db_xref="dbSNP:199879101"
     variation       1152
                     /replace="f"
                     /db_xref="dbSNP:1277263770"
     variation       1153
                     /replace="a"
                     /db_xref="dbSNP:1440375622"
     variation       1153
                     /replace="t"
                     /db_xref="dbSNP:12172761"
     variation       1154
                     /replace="a"
                     /db_xref="dbSNP:1217491565"
     variation       1155
                     /replace="g"
                     /db_xref="dbSNP:770919807"
     variation       1156
                     /replace="-"
                     /db_xref="dbSNP:774023781"
     variation       1156
                     /replace="s"
                     /db_xref="dbSNP:1262265732"
     Site            1159
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000244|PubMed:19690332};
                     propagated from UniProtKB/Swiss-Prot (Q13136.1)"
     variation       1161
                     /replace="p"
                     /db_xref="dbSNP:1207677474"
     variation       1162
                     /replace="a"
                     /db_xref="dbSNP:144543406"
     variation       1162
                     /replace="e"
                     /db_xref="dbSNP:776633301"
     variation       1163
                     /replace="d"
                     /db_xref="dbSNP:1377819323"
     variation       1163
                     /replace="n"
                     /db_xref="dbSNP:1478582666"
     variation       1164
                     /replace="c"
                     /db_xref="dbSNP:1174669752"
     variation       1165
                     /replace="q"
                     /db_xref="dbSNP:894067451"
     variation       1165
                     /replace="r"
                     /db_xref="dbSNP:770901115"
     variation       1165
                     /replace="w"
                     /db_xref="dbSNP:373954004"
     variation       1166
                     /replace="e"
                     /db_xref="dbSNP:762176048"
     variation       1166
                     /replace="m"
                     /db_xref="dbSNP:375719549"
     variation       1167
                     /replace="p"
                     /db_xref="dbSNP:946918498"
     variation       1168
                     /replace="a"
                     /db_xref="dbSNP:1364501986"
     variation       1169
                     /replace="-"
                     /db_xref="dbSNP:745743813"
     variation       1170
                     /replace="v"
                     /db_xref="dbSNP:1045260662"
     variation       1172
                     /replace="s"
                     /db_xref="dbSNP:374468603"
     variation       1173
                     /replace="p"
                     /db_xref="dbSNP:750888185"
     variation       1173
                     /replace="r"
                     /db_xref="dbSNP:1331897165"
     variation       1173
                     /replace="s"
                     /db_xref="dbSNP:1328484968"
     variation       1174
                     /replace="y"
                     /db_xref="dbSNP:761127513"
     variation       1175
                     /replace="t"
                     /db_xref="dbSNP:1219124697"
     variation       1175
                     /replace="v"
                     /db_xref="dbSNP:149297474"
     variation       1178
                     /replace="n"
                     /db_xref="dbSNP:1432034327"
     variation       1179
                     /replace="-"
                     /db_xref="dbSNP:1259458204"
     variation       1179
                     /replace="n"
                     /db_xref="dbSNP:778522652"
     variation       1179
                     /replace="q"
                     /db_xref="dbSNP:377595494"
     variation       1179
                     /replace="r"
                     /db_xref="dbSNP:547523713"
     variation       1181
                     /replace="r"
                     /db_xref="dbSNP:370637836"
     variation       1182
                     /replace="i"
                     /db_xref="dbSNP:758105098"
     variation       1183
                     /replace="d"
                     /db_xref="dbSNP:200466484"
     CDS             1..1185
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="NM_177423.2:216..3773"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS31628.1"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alskaeerhg nieerlrqme
      421 aqleeknqel qrarqrekmn eehnkrlsdt vdkllsesne rlqlhlkerm aaledknsll
      481 revesakkql eetqhdkdql vlniealrae ldhmrlrgas lhhgrphlgs vpdfrfpmad
      541 ghtdsystsa vlrrpqkgrl aalrdepskv qtlneqdwer aqqasvlanv aqafesdadv
      601 sdgeddrdtl lssvdllsps gqadahtlam mlqeqldain keirliqeek enteqraeei
      661 esrvgsgsld nlgrfrsmss ippypassla sssppgsgrs tprriphspa revdrlgvmt
      721 llppsreevr ddkttikcet sppsspralr ldrlhkgalh tvshedirdi rnstgsqdgp
      781 vsnpsssnss qdslhkapkk kgikssigrl fgkkekgrpg qtgkealgqa gvsetdnssq
      841 dalglsklgg qaeknrklqk khelleearr qglpfaqwdg ptvvvwlelw vgmpawyvaa
      901 cranvksgai msalsdteiq reigisnplh rlklrlaiqe imsltspsap ptsrttlayg
      961 dmnhewigne wlpslglpqy rsyfmeclvd armldhltkk dlrgqlkmvd sfhrnsfqcg
     1021 imclrrlnyd rkelerkree sqseikdvlv wsndrvirwi lsiglkeyan nliesgvhga
     1081 llaldetfdf salalllqip tqntqaravl erefnnllvm gtdrrfdedd dksfrrapsw
     1141 rkkfrpkdir glaagsaetl panfrvtssm sspsmqpkkm qmdgm
//
DBGET integrated database retrieval system