LOCUS NP_861516 150 aa linear PRI 01-JAN-2024
DEFINITION ubiquitin-conjugating enzyme E2 C isoform 3 [Homo sapiens].
ACCESSION NP_861516
VERSION NP_861516.1
DBSOURCE REFSEQ: accession NM_181800.3
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 150)
AUTHORS Ong KH, Lai HY, Sun DP, Chen TJ, Huang SK, Tian YF, Chou CL, Shiue
YL, Chan TC, Li CF and Kuo YH.
TITLE Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator
for cholangiocarcinoma
JOURNAL Eur J Med Res 28 (1), 593 (2023)
PUBMED 38102624
REMARK GeneRIF: Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic
indicator for cholangiocarcinoma.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 150)
AUTHORS Domentean S, Paisana E, Cascao R and Faria CC.
TITLE Role of UBE2C in Brain Cancer Invasion and Dissemination
JOURNAL Int J Mol Sci 24 (21), 15792 (2023)
PUBMED 37958776
REMARK GeneRIF: Role of UBE2C in Brain Cancer Invasion and Dissemination.
Review article
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 150)
AUTHORS Liu D, Guan X, Liu W, Jia Y, Zhou H, Xi C, Zhao M, Fang Y, Wu L and
Li K.
TITLE Identification of transcriptome characteristics of granulosa cells
and the possible role of UBE2C in the pathogenesis of premature
ovarian insufficiency
JOURNAL J Ovarian Res 16 (1), 203 (2023)
PUBMED 37848988
REMARK GeneRIF: Identification of transcriptome characteristics of
granulosa cells and the possible role of UBE2C in the pathogenesis
of premature ovarian insufficiency.
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 150)
AUTHORS Li X, Ma Z and Mei L.
TITLE Comprehensive analysis of UBE2C expression and its potential roles
and mechanisms in hepatocellular carcinoma
JOURNAL Aging (Albany NY) 15 (15), 7397-7407 (2023)
PUBMED 37580802
REMARK GeneRIF: Comprehensive analysis of UBE2C expression and its
potential roles and mechanisms in hepatocellular carcinoma.
REFERENCE 5 (residues 1 to 150)
AUTHORS Huang R, Guo L, Chen C, Xiang Y, Li G, Zheng J, Wu Y, Yuan X, Zhou
J, Gao W and Xiang S.
TITLE System analysis identifies UBE2C as a novel oncogene target for
adrenocortical carcinoma
JOURNAL PLoS One 18 (8), e0289418 (2023)
PUBMED 37535572
REMARK GeneRIF: System analysis identifies UBE2C as a novel oncogene
target for adrenocortical carcinoma.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 150)
AUTHORS Okamoto Y, Ozaki T, Miyazaki K, Aoyama M, Miyazaki M and Nakagawara
A.
TITLE UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme
JOURNAL Cancer Res 63 (14), 4167-4173 (2003)
PUBMED 12874022
REMARK GeneRIF: UbcH10 is highly expressed in various human primary tumors
and UbcH10 has an ability to promote cell growth and malignant
transformation.
REFERENCE 7 (residues 1 to 150)
AUTHORS Yurchenko V, Xue Z and Sadofsky M.
TITLE The RAG1 N-terminal domain is an E3 ubiquitin ligase
JOURNAL Genes Dev 17 (5), 581-585 (2003)
PUBMED 12629039
REFERENCE 8 (residues 1 to 150)
AUTHORS Lin Y, Hwang WC and Basavappa R.
TITLE Structural and functional analysis of the human mitotic-specific
ubiquitin-conjugating enzyme, UbcH10
JOURNAL J Biol Chem 277 (24), 21913-21921 (2002)
PUBMED 11927573
REFERENCE 9 (residues 1 to 150)
AUTHORS Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, Deisenhofer J
and Yu H.
TITLE APC2 Cullin protein and APC11 RING protein comprise the minimal
ubiquitin ligase module of the anaphase-promoting complex
JOURNAL Mol Biol Cell 12 (12), 3839-3851 (2001)
PUBMED 11739784
REFERENCE 10 (residues 1 to 150)
AUTHORS Townsley FM, Aristarkhov A, Beck S, Hershko A and Ruderman JV.
TITLE Dominant-negative cyclin-selective ubiquitin carrier protein
E2-C/UbcH10 blocks cells in metaphase
JOURNAL Proc Natl Acad Sci U S A 94 (6), 2362-2367 (1997)
PUBMED 9122200
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB062573.1, CK904708.1 and
BC007656.2.
Summary: The modification of proteins with ubiquitin is an
important cellular mechanism for targeting abnormal or short-lived
proteins for degradation. Ubiquitination involves at least three
classes of enzymes: ubiquitin-activating enzymes,
ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This
gene encodes a member of the E2 ubiquitin-conjugating enzyme
family. The encoded protein is required for the destruction of
mitotic cyclins and for cell cycle progression, and may be involved
in cancer progression. Multiple transcript variants encoding
different isoforms have been found for this gene. Pseudogenes of
this gene have been defined on chromosomes 4, 14, 15, 18, and 19.
[provided by RefSeq, Aug 2013].
Transcript Variant: This variant (3) lacks an in-frame exon in the
central coding region, compared to variant 1. The encoded isoform
(3) is shorter, compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR7346977.698492.1, BF684237.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..150
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="20"
/map="20q13.12"
Protein 1..150
/product="ubiquitin-conjugating enzyme E2 C isoform 3"
/EC_number="2.3.2.23"
/EC_number="2.3.2.24"
/note="ubiquitin-protein ligase C; cyclin-selective
ubiquitin carrier protein; mitotic-specific
ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating
enzyme C; (E3-independent) E2 ubiquitin-conjugating enzyme
C; ubiquitin conjugating enzyme E2C"
/calculated_mol_wt=16545
Site order(33,61..62,95..96)
/site_type="active"
/note="E3 interaction residues [active]"
/db_xref="CDD:238117"
Region <44..141
/region_name="UQ_con"
/note="Ubiquitin-conjugating enzyme; pfam00179"
/db_xref="CDD:395127"
Site order(72..73,77..78,80,84..86,88..89,93..94,97,102,105,
108,111..112,114,116..117)
/site_type="active"
/note="Ub thioester intermediate interaction residues
[active]"
/db_xref="CDD:238117"
Site 85
/site_type="active"
/note="active site cysteine"
/db_xref="CDD:238117"
CDS 1..150
/gene="UBE2C"
/gene_synonym="dJ447F3.2; UBCH10"
/coded_by="NM_181800.3:53..505"
/note="isoform 3 is encoded by transcript variant 3"
/db_xref="CCDS:CCDS13372.1"
/db_xref="GeneID:11065"
/db_xref="HGNC:HGNC:15937"
/db_xref="MIM:605574"
ORIGIN
1 masqnrdpaa tsvaaarkga epsggaargp vgkrlqqelm tlmvyedlry klslefpsgy
61 pynaptvkfl tpcyhpnvdt qgnicldilk ekwsalydvr tillsiqsll gepnidspln
121 thaaelwknp tafkkylqet yskqvtsqep
//
