GenomeNet

Database: RefSeq
Entry: NP_963285
LinkDB: NP_963285
Original site: NP_963285 
LOCUS       NP_963285                222 aa            linear   MAM 08-DEC-2018
DEFINITION  superoxide dismutase [Mn], mitochondrial precursor [Bos taurus].
ACCESSION   NP_963285 XP_618345
VERSION     NP_963285.2
DBSOURCE    REFSEQ: accession NM_201527.2
KEYWORDS    RefSeq.
SOURCE      Bos taurus (cattle)
  ORGANISM  Bos taurus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
            Pecora; Bovidae; Bovinae; Bos.
REFERENCE   1  (residues 1 to 222)
  AUTHORS   Lau A, Kollara A, St John E, Tone AA, Virtanen C, Greenblatt EM,
            King WA and Brown TJ.
  TITLE     Altered expression of inflammation-associated genes in oviductal
            cells following follicular fluid exposure: implications for ovarian
            carcinogenesis
  JOURNAL   Exp. Biol. Med. (Maywood) 239 (1), 24-32 (2014)
   PUBMED   24186266
  REMARK    GeneRIF: Exposure to follicular fluid transiently increased the
            transcript levels of IL8 and PTGS2, and decreased the expression of
            SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased
            while those of NAMPT were unaffected.
REFERENCE   2  (residues 1 to 222)
  AUTHORS   Brenner MP, Silva-Frade C, Ferrarezi MC, Garcia AF, Flores EF and
            Cardoso TC.
  TITLE     Evaluation of developmental changes in bovine in vitro produced
            embryos following exposure to bovine Herpesvirus type 5
  JOURNAL   Reprod. Biol. Endocrinol. 10, 53 (2012)
   PUBMED   22823939
  REMARK    GeneRIF: Data suggest that during ectogenesis of blastocysts
            infected with bovine Herpesvirus type 5, expression of SOD2 (Mn)
            remains high indicating intense mitochondrial activity; this effect
            may be involved in inhibition of apoptosis in infected embryos.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 222)
  AUTHORS   Combelles CM, Holick EA, Paolella LJ, Walker DC and Wu Q.
  TITLE     Profiling of superoxide dismutase isoenzymes in compartments of the
            developing bovine antral follicles
  JOURNAL   Reproduction 139 (5), 871-881 (2010)
   PUBMED   20197373
  REMARK    GeneRIF: expression profile of SOD2 in follicles: oocytes (SOD2
            restricted to ooplasm); cumulus cells (expressed some SOD2);
            follicular fluid (small follicles show increased amounts of SOD2 in
            comparison with large follicles)
REFERENCE   4  (residues 1 to 222)
  AUTHORS   Kienhofer J, Haussler DJ, Ruckelshausen F, Muessig E, Weber K,
            Pimentel D, Ullrich V, Burkle A and Bachschmid MM.
  TITLE     Association of mitochondrial antioxidant enzymes with mitochondrial
            DNA as integral nucleoid constituents
  JOURNAL   FASEB J. 23 (7), 2034-2044 (2009)
   PUBMED   19228881
  REMARK    GeneRIF: Heart mitochondrial nucleoids contained SOD2, aortic
            endothelial cell mitochondrial nucleoids did not
REFERENCE   5  (residues 1 to 222)
  AUTHORS   Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D,
            Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G,
            Roberts M, Subramanian P, Yorke JA and Salzberg SL.
  TITLE     A whole-genome assembly of the domestic cow, Bos taurus
  JOURNAL   Genome Biol. 10 (4), R42 (2009)
   PUBMED   19393038
REFERENCE   6  (residues 1 to 222)
  AUTHORS   Ai L, Rouhanizadeh M, Wu JC, Takabe W, Yu H, Alavi M, Li R, Chu Y,
            Miller J, Heistad DD and Hsiai TK.
  TITLE     Shear stress influences spatial variations in vascular Mn-SOD
            expression: implication for LDL nitration
  JOURNAL   Am. J. Physiol., Cell Physiol. 294 (6), C1576-C1585 (2008)
   PUBMED   18434620
  REMARK    GeneRIF: Shear stress influences spatial variations in vascular
            Mn-SOD expression with implications for LDL nitration.
REFERENCE   7  (residues 1 to 222)
  AUTHORS   Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling
            WM, Wiedmann RT, Van Tassell CP and Smith TP.
  TITLE     Characterization of 954 bovine full-CDS cDNA sequences
  JOURNAL   BMC Genomics 6, 166 (2005)
   PUBMED   16305752
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 222)
  AUTHORS   Ishiwata H, Katsuma S, Kizaki K, Patel OV, Nakano H, Takahashi T,
            Imai K, Hirasawa A, Shiojima S, Ikawa H, Suzuki Y, Tsujimoto G,
            Izaike Y, Todoroki J and Hashizume K.
  TITLE     Characterization of gene expression profiles in early bovine
            pregnancy using a custom cDNA microarray
  JOURNAL   Mol. Reprod. Dev. 65 (1), 9-18 (2003)
   PUBMED   12658628
REFERENCE   9  (residues 1 to 222)
  AUTHORS   Sonstegard TS, Capuco AV, White J, Van Tassell CP, Connor EE, Cho
            J, Sultana R, Shade L, Wray JE, Wells KD and Quackenbush J.
  TITLE     Analysis of bovine mammary gland EST and functional annotation of
            the Bos taurus gene index
  JOURNAL   Mamm. Genome 13 (7), 373-379 (2002)
   PUBMED   12140684
REFERENCE   10 (residues 1 to 222)
  AUTHORS   Meyrick B and Magnuson MA.
  TITLE     Identification and functional characterization of the bovine
            manganous superoxide dismutase promoter
  JOURNAL   Am. J. Respir. Cell Mol. Biol. 10 (1), 113-121 (1994)
   PUBMED   8292376
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105378.1.
            On Feb 26, 2006 this sequence version replaced NP_963285.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03145413, SAMN03145414
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Bos taurus"
                     /db_xref="taxon:9913"
                     /chromosome="9"
                     /map="9"
                     /breed="mixed"
     Protein         1..222
                     /product="superoxide dismutase [Mn], mitochondrial
                     precursor"
                     /EC_number="1.15.1.1"
                     /note="superoxide dismutase [Mn], mitochondrial; manganous
                     superoxide dismutase; superoxide dismutase 2,
                     mitochondrial"
                     /calculated_mol_wt=22096
     transit_peptide 1..24
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Mitochondrion. {ECO:0000250}; propagated from
                     UniProtKB/Swiss-Prot (P41976.1)"
                     /calculated_mol_wt=2560
     Region          23..219
                     /region_name="SodA"
                     /note="Superoxide dismutase [Inorganic ion transport and
                     metabolism]; COG0605"
                     /db_xref="CDD:223678"
     mat_peptide     25..222
                     /product="Superoxide dismutase [Mn], mitochondrial"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P41976.1)"
                     /calculated_mol_wt=22096
     Region          25..106
                     /region_name="Sod_Fe_N"
                     /note="Iron/manganese superoxide dismutases, alpha-hairpin
                     domain; pfam00081"
                     /db_xref="CDD:278509"
     Site            58
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Nitrated tyrosine. {ECO:0000250|UniProtKB:P04179};
                     propagated from UniProtKB/Swiss-Prot (P41976.1)"
     Site            68
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000250|UniProtKB:P04179}; propagated from
                     UniProtKB/Swiss-Prot (P41976.1)"
     Site            68
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000250|UniProtKB:P09671}; propagated from
                     UniProtKB/Swiss-Prot (P41976.1)"
     Site            75
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000250|UniProtKB:P09671}; propagated from
                     UniProtKB/Swiss-Prot (P41976.1)"
     Site            75
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000250|UniProtKB:P09671}; propagated from
                     UniProtKB/Swiss-Prot (P41976.1)"
     Region          113..216
                     /region_name="Sod_Fe_C"
                     /note="Iron/manganese superoxide dismutases, C-terminal
                     domain; pfam02777"
                     /db_xref="CDD:280872"
     Site            122
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000250|UniProtKB:P09671}; propagated from
                     UniProtKB/Swiss-Prot (P41976.1)"
     Site            122
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000250|UniProtKB:P09671}; propagated from
                     UniProtKB/Swiss-Prot (P41976.1)"
     Site            130
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000250|UniProtKB:P04179}; propagated from
                     UniProtKB/Swiss-Prot (P41976.1)"
     Site            130
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000250|UniProtKB:P09671}; propagated from
                     UniProtKB/Swiss-Prot (P41976.1)"
     Site            202
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:P09671};
                     propagated from UniProtKB/Swiss-Prot (P41976.1)"
     CDS             1..222
                     /gene="SOD2"
                     /gene_synonym="MnSOD"
                     /coded_by="NM_201527.2:70..738"
                     /db_xref="BGD:BT29128"
                     /db_xref="GeneID:281496"
ORIGIN      
        1 mlsraacsts rrlvpalsvl gsrqkhslpd lpydygalep hinaqimqlh hskhhaayvn
       61 nlnvaeekyr ealekgdvta qialqpalkf nggghinhsi fwtnlspngg gepqgellea
      121 ikrdfgsfak fkekltavsv gvqgsgwgwl gfnkeqgrlq iaacsnqdpl qgttglipll
      181 gidvwehayy lqyknvrpdy lkaiwnvinw envtarytac sk
//
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