LOCUS NP_989644 1080 aa linear VRT 23-SEP-2023
DEFINITION histone deacetylase 4 [Gallus gallus].
ACCESSION NP_989644
VERSION NP_989644.1
DBSOURCE REFSEQ: accession NM_204313.2
KEYWORDS RefSeq.
SOURCE Gallus gallus (chicken)
ORGANISM Gallus gallus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
REFERENCE 1 (residues 1 to 1080)
AUTHORS Tang H, Finn RD and Thomas PD.
TITLE TreeGrafter: phylogenetic tree-based annotation of proteins with
Gene Ontology terms and other annotations
JOURNAL Bioinformatics 35 (3), 518-520 (2019)
PUBMED 30032202
REFERENCE 2 (residues 1 to 1080)
AUTHORS Guan Y, Chen Q, Yang X, Haines P, Pei M, Terek R, Wei X, Zhao T and
Wei L.
TITLE Subcellular relocation of histone deacetylase 4 regulates growth
plate chondrocyte differentiation through Ca2+/calmodulin-dependent
kinase IV
JOURNAL Am J Physiol Cell Physiol 303 (1), C33-C40 (2012)
PUBMED 22442139
REMARK GeneRIF: findings indicate that HDAC4 nuclear-cytoplasmic shuttling
controls chondrocyte differentiation in the growth plate, which is
dependent on the Ca2 /calmodulin signaling pathway
REFERENCE 3 (residues 1 to 1080)
AUTHORS Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
TITLE Manual GO annotation of predictive protein signatures: the InterPro
approach to GO curation
JOURNAL Database (Oxford) 2012, bar068 (2012)
PUBMED 22301074
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 1080)
AUTHORS Hori T, Amano M, Suzuki A, Backer CB, Welburn JP, Dong Y, McEwen
BF, Shang WH, Suzuki E, Okawa K, Cheeseman IM and Fukagawa T.
TITLE CCAN makes multiple contacts with centromeric DNA to provide
distinct pathways to the outer kinetochore
JOURNAL Cell 135 (6), 1039-1052 (2008)
PUBMED 19070575
REFERENCE 5 (residues 1 to 1080)
AUTHORS Verdin E, Dequiedt F and Kasler HG.
TITLE Class II histone deacetylases: versatile regulators
JOURNAL Trends Genet 19 (5), 286-293 (2003)
PUBMED 12711221
REMARK Review article
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from
JAENSK010000235.1.
##Evidence-Data-START##
Transcript exon combination :: AB052839.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA103992290,
SAMEA103992323 [ECO:0006172]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..1080
/organism="Gallus gallus"
/db_xref="taxon:9031"
/chromosome="7"
/map="7"
Protein 1..1080
/product="histone deacetylase 4"
/EC_number="3.5.1.98"
/note="HD4; osteoblast regulatory factor 3A"
/calculated_mol_wt=119337
Region 1..25
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P83038.1)"
Region <91..151
/region_name="ClassIIa_HDAC4_Gln-rich-N"
/note="Glutamine-rich N-terminal helical domain of HDAC4,
a Class IIa histone deacetylase; cd10162"
/db_xref="CDD:197398"
Site order(93,97,108..109,112,118,122..123)
/site_type="other"
/note="dimer interface A, B [polypeptide binding]"
/db_xref="CDD:197398"
Region 132..165
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P83038.1)"
Region 205..312
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P83038.1)"
Region 348..353
/region_name="PxLPxI/L.
/evidence=ECO:0000250|UniProtKB:P56524"
/note="propagated from UniProtKB/Swiss-Prot (P83038.1)"
Region 506..527
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P83038.1)"
Region 558..579
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P83038.1)"
Region 622..646
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P83038.1)"
Region 645..1053
/region_name="HDAC4"
/note="Histone deacetylase 4; cd10006"
/db_xref="CDD:212530"
Region 651..1080
/region_name="Histone deacetylase"
/note="propagated from UniProtKB/Swiss-Prot (P83038.1)"
Site order(798..799,807..808,836,838,930,970)
/site_type="active"
/db_xref="CDD:212530"
Region 1055..1080
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P83038.1)"
CDS 1..1080
/gene="HDAC4"
/coded_by="NM_204313.2:359..3601"
/db_xref="CGNC:49084"
/db_xref="GeneID:374207"
ORIGIN
1 mssqshpdgl sgrdqpvell npprvnhmps svdvstalpl qvaptsvpmd lrldhqfpmp
61 vteptlreqq lqqellalkq kqqiqrqili aefqrqheql srqheaqlhe hikqqemlam
121 khqqellehq rkleqhrqeq elekqhreqk lqqlknkekg kesavastev kmklqefvln
181 kkkalahrnl nhcissdprf wygktqhssl dqssppqsgv sgtynhpvlg mydskddfpl
241 rktasepnlk lrsrlkqkva errsspllrr kdgpvvtalk krpldvtdsa cnsapgsgps
301 spnnssnnis aengitgsvt siqaetslah rlvnregsvt qlplytspsl pnitlglpat
361 gpssggsaqq daerlaipal qqrislfpgt hltpylsttt lerdggtahn pllqhmvlle
421 qptaqtplvt glplhaqslv ggervspsih klrqhrplgr tqsaplpqna qalqqlviqq
481 qhqqflekhk qqfqqqqlhi nkiiskpnep arqheshpee teeelrehqa lleepysdrv
541 ssqkevpgla nmvqvkqepi esdeeeaepq qelesgqrqa eqellfrqqa llleqqrihq
601 lrnyqaslea agmpvsfggh rplsraqssp asatfpmsvq epptkprftt glvydtlmlk
661 hqctcgntns hpehagriqs iwsrlqetgl rgkcecirgr katleelqtv hseahtllyg
721 tnplnrqkld skkllgslts mfvrlpcggv gvdsdtiwne vhssgaarla vgcvielvfk
781 vatgelkngf avvrppghha eestpmgfcy fnsvaiaakl lqqrlnvski livdwdvhhg
841 ngtqqafynd pnvlyislhr yddgnffpgs gapdevgtga gvgfnvnmaf tggldppmgd
901 teyltafrtv vmpianefap dvvlvssgfd aveghptplg gynlsakcfg yltkqlmgla
961 ggrvvlaleg ghdltaicda seacvsallg neldplpekv lqqrananav hsmekvieih
1021 skywhslqry astvgyslve aqkceneeae tvtamaslsv gvkpaekrpd depmeeeppl
//
