GenomeNet

Database: RefSeq
Entry: NP_990229
LinkDB: NP_990229
Original site: NP_990229 
LOCUS       NP_990229                224 aa            linear   VRT 16-FEB-2019
DEFINITION  thymidine kinase, cytosolic [Gallus gallus].
ACCESSION   NP_990229 XP_420091
VERSION     NP_990229.1
DBSOURCE    REFSEQ: accession NM_204898.1
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (residues 1 to 224)
  AUTHORS   Mutahir Z, Clausen AR, Andersson KM, Wisen SM, Munch-Petersen B and
            Piskur J.
  TITLE     Thymidine kinase 1 regulatory fine-tuning through tetramer
            formation
  JOURNAL   FEBS J. 280 (6), 1531-1541 (2013)
   PUBMED   23351158
REFERENCE   2  (residues 1 to 224)
  AUTHORS   Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong
            WT, Tickle C, Brown WR, Wilson SA and Hubbard SJ.
  TITLE     A comprehensive collection of chicken cDNAs
  JOURNAL   Curr. Biol. 12 (22), 1965-1969 (2002)
   PUBMED   12445392
REFERENCE   3  (residues 1 to 224)
  AUTHORS   Merrill,G.F. and Tufaro,F.D.
  TITLE     Structural and functional analysis of an alternatively spliced
            chicken TK messenger RNA
  JOURNAL   Nucleic Acids Res. 14 (15), 6281-6297 (1986)
   PUBMED   3755819
REFERENCE   4  (residues 1 to 224)
  AUTHORS   Merrill,G.F., Harland,R.M., Groudine,M. and McKnight,S.L.
  TITLE     Genetic and physical analysis of the chicken tk gene
  JOURNAL   Mol. Cell. Biol. 4 (9), 1769-1776 (1984)
   PUBMED   6092937
REFERENCE   5  (residues 1 to 224)
  AUTHORS   Kwoh,T.J. and Engler,J.A.
  TITLE     The nucleotide sequence of the chicken thymidine kinase gene and
            the relationship of its predicted polypeptide to that of the
            vaccinia virus thymidine kinase
  JOURNAL   Nucleic Acids Res. 12 (9), 3959-3971 (1984)
   PUBMED   6328447
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BU439002.1.
            On Oct 9, 2004 this sequence version replaced XP_420091.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU439002.1, AJ451815.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..224
                     /organism="Gallus gallus"
                     /db_xref="taxon:9031"
                     /chromosome="18"
                     /map="18"
     Protein         1..224
                     /product="thymidine kinase, cytosolic"
                     /EC_number="2.7.1.21"
                     /note="thymidine kinase 1, soluble"
                     /calculated_mol_wt=24741
     Region          18..208
                     /region_name="TK"
                     /note="Thymidine kinase; cl23762"
                     /db_xref="CDD:304919"
     Region          173..177
                     /region_name="Substrate binding. {ECO:0000250}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P04047.1)"
     CDS             1..224
                     /gene="TK1"
                     /gene_synonym="TK"
                     /coded_by="NM_204898.1:15..689"
                     /db_xref="CGNC:5434"
                     /db_xref="GeneID:395719"
ORIGIN      
        1 mncltvpgvh pgspgrprgq iqvifgpmfs gkstelmrrv rrfqlaqyrc llvkyakdtr
       61 ycttgvsthd rntmearpac alqdvyqeal gsavigideg qffpdivefc ekmantgktv
      121 ivaaldgtfq rkafgsilnl vplaesvvkl navcmecyre asytkrlgae reveviggad
      181 kyhsvcracy fqkrpqqlgs enkenvpmgv kqldmpasrk ifas
//
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