LOCUS NP_997507 1312 aa linear ROD 23-DEC-2018
DEFINITION angiotensin-converting enzyme isoform 1 precursor [Mus musculus].
ACCESSION NP_997507
VERSION NP_997507.1
DBSOURCE REFSEQ: accession NM_207624.5
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 1312)
AUTHORS Moraes OA, Flues K, Scapini KB, Mostarda C, Evangelista FS,
Rodrigues B, Dartora DR, Fiorino P, Angelis K and Irigoyen MC.
TITLE ACE gene dosage determines additional autonomic dysfunction and
increases renal angiotensin II levels in diabetic mice
JOURNAL Clinics (Sao Paulo) 73, e246 (2018)
PUBMED 30088535
REMARK GeneRIF: a small increase in angiotensin-converting enzyme activity
in diabetic animals leads to greater impairment of autonomic
function, as demonstrated by increased sympathetic modulation and
reduced cardiac vagal modulation along with increased renal
expression of Ang II.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 1312)
AUTHORS Srivillibhuthur M, Warder BN, Toke NH, Shah PP, Feng Q, Gao N,
Bonder EM and Verzi MP.
TITLE TFAM is required for maturation of the fetal and adult intestinal
epithelium
JOURNAL Dev. Biol. 439 (2), 92-101 (2018)
PUBMED 29684311
REFERENCE 3 (residues 1 to 1312)
AUTHORS Kohlstedt K, Trouvain C, Fromel T, Mudersbach T, Henschler R and
Fleming I.
TITLE Role of the angiotensin-converting enzyme in the G-CSF-induced
mobilization of progenitor cells
JOURNAL Basic Res. Cardiol. 113 (3), 18 (2018)
PUBMED 29549541
REMARK GeneRIF: ACE expression/phosphorylation in the bone-marrow niche
interface negatively regulates G-CSF-induced signaling and
hematopoietic progenitor cell mobilization.
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 1312)
AUTHORS Moran CS, Biros E, Krishna SM, Wang Y, Tikellis C, Morton SK, Moxon
JV, Cooper ME, Norman PE, Burrell LM, Thomas MC and Golledge J.
TITLE Resveratrol Inhibits Growth of Experimental Abdominal Aortic
Aneurysm Associated With Upregulation of Angiotensin-Converting
Enzyme 2
JOURNAL Arterioscler. Thromb. Vasc. Biol. 37 (11), 2195-2203 (2017)
PUBMED 28935757
REMARK GeneRIF: Resveratrol upregulated ACE2 and inhibited abdominal
aortic aneurysm growth in a mouse model.
REFERENCE 5 (residues 1 to 1312)
AUTHORS Song R, Lopez MLSS and Yosypiv IV.
TITLE Foxd1 is an upstream regulator of the renin-angiotensin system
during metanephric kidney development
JOURNAL Pediatr. Res. 82 (5), 855-862 (2017)
PUBMED 28665931
REFERENCE 6 (residues 1 to 1312)
AUTHORS Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D, Luc
G, Bard JM, Bara L, Ricard S et al.
TITLE Deletion polymorphism in the gene for angiotensin-converting enzyme
is a potent risk factor for myocardial infarction
JOURNAL Nature 359 (6396), 641-644 (1992)
PUBMED 1328889
REFERENCE 7 (residues 1 to 1312)
AUTHORS Langford KG, Shai SY, Howard TE, Kovac MJ, Overbeek PA and
Bernstein KE.
TITLE Transgenic mice demonstrate a testis-specific promoter for
angiotensin-converting enzyme
JOURNAL J. Biol. Chem. 266 (24), 15559-15562 (1991)
PUBMED 1651914
REFERENCE 8 (residues 1 to 1312)
AUTHORS Howard TE, Shai SY, Langford KG, Martin BM and Bernstein KE.
TITLE Transcription of testicular angiotensin-converting enzyme (ACE) is
initiated within the 12th intron of the somatic ACE gene
JOURNAL Mol. Cell. Biol. 10 (8), 4294-4302 (1990)
PUBMED 2164636
REFERENCE 9 (residues 1 to 1312)
AUTHORS Shai SY, Langford KG, Martin BM and Bernstein KE.
TITLE Genomic DNA 5' to the mouse and human angiotensin-converting enzyme
genes contains two distinct regions of conserved sequence
JOURNAL Biochem. Biophys. Res. Commun. 167 (3), 1128-1133 (1990)
PUBMED 2157425
REFERENCE 10 (residues 1 to 1312)
AUTHORS Bernstein KE, Martin BM, Edwards AS and Bernstein EA.
TITLE Mouse angiotensin-converting enzyme is a protein composed of two
homologous domains
JOURNAL J. Biol. Chem. 264 (20), 11945-11951 (1989)
PUBMED 2545691
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BY210311.1, AK161020.1 and AL731865.9.
Transcript Variant: This variant (1) encodes the longest isoform
(1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK154632.1, AK161020.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..1312
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="11"
/map="11 68.84 cM"
Protein 1..1312
/product="angiotensin-converting enzyme isoform 1
precursor"
/EC_number="3.4.15.1"
/note="dipeptidyl peptidase; kininase II; dipeptidyl
carboxypeptidase I; angiotensin-converting enzyme"
/calculated_mol_wt=147398
sig_peptide 1..34
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=3539
mat_peptide 35..1312
/product="Angiotensin-converting enzyme"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P09470.3)"
/calculated_mol_wt=147398
mat_peptide 35..1237
/product="Angiotensin-converting enzyme, soluble form"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P09470.3)"
/calculated_mol_wt=138974
Region 35..635
/region_name="Peptidase M2 1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P09470.3)"
Region 45..628
/region_name="Peptidase_M2"
/note="Angiotensin-converting enzyme; pfam01401"
/db_xref="CDD:279709"
Site order(365..367,395..396,399,423,469,523..525,530,532,535)
/site_type="active"
/db_xref="CDD:188999"
Site order(395,399,423)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:188999"
Region 636..1237
/region_name="Peptidase M2 2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P09470.3)"
Region 649..1226
/region_name="Peptidase_M2"
/note="Angiotensin-converting enzyme; pfam01401"
/db_xref="CDD:279709"
Site order(963..965,993..994,997,1021,1067,1121..1123,1128,
1130,1133)
/site_type="active"
/db_xref="CDD:188999"
Site order(993,997,1021)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:188999"
Site 1265..1281
/site_type="transmembrane region"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P09470.3)"
Site 1305
/site_type="other"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:21183079};
propagated from UniProtKB/Swiss-Prot (P09470.3)"
CDS 1..1312
/gene="Ace"
/gene_synonym="AW208573; CD143"
/coded_by="NM_207624.5:38..3976"
/note="isoform 1 precursor is encoded by transcript
variant 1"
/db_xref="CCDS:CCDS25543.1"
/db_xref="GeneID:11421"
/db_xref="MGI:MGI:87874"
ORIGIN
1 mgaasgqrgr wplsppllml sllvlllqps papaldpglq pgnfspdeag aqlfaesyns
61 saevvmfqst vaswahdtni teenarrqee aalvsqefae vwgkkakely esiwqnftds
121 klrriigsir tlgpanlpla qrqqynslls nmsriystgk vcfpnktatc wsldpeltni
181 lassrsyakl lfawegwhda vgiplkplyq dftaisneay rqddfsdtga fwrswyesps
241 feeslehiyh qleplylnlh ayvrralhrr ygdkyvnlrg pipahllgdm waqsweniyd
301 mvvpfpdkpn ldvtstmvqk gwnathmfrv seefftslgl spmppefwae smlekptdgr
361 evvchasawd fynrkdfrik qctrvtmeql atvhhemghv qyylqykdlh vslrrganpg
421 fheaigdvla lsvstpahlh kiglldhvtn diesdinyll kmalekiafl pfgylvdqwr
481 wgvfsgrtpp srynfdwwyl rtkyqgicpp varnethfda gakfhipnvt pyiryfvsfv
541 lqfqfhqalc keaghqgplh qcdiyqsaqa gaklkqvlqa gcsrpwqevl kdlvgsdald
601 akalleyfqp vsqwleeqnq rngevlgwpe nqwrpplpdn ypegidletd eakadrfvee
661 ydrtaqvlln eyaeanwqyn tnitiegski llekstevsn htlkygtrak tfdvsnfqns
721 sikriikklq nldravlppk eleeynqill dmettyslsn icytngtcmp lepdltnmma
781 tsrkyeellw awkswrdkvg railpffpky vefsnkiakl ngytdagdsw rslyesdnle
841 qdleklyqel qplylnlhay vrrslhrhyg seyinldgpi pahllgnmwa qtwsniydlv
901 apfpsapnid ateamikqgw tprrifkead nfftslgllp vppefwnksm lekptdgrev
961 vchpsawdfy ngkdfrikqc tsvnmedlvi ahhemghiqy fmqykdlpvt freganpgfh
1021 eaigdimals vstpkhlysl nllstegsgy eydinflmkm aldkiafipf sylidqwrwr
1081 vfdgsitken ynqewwslrl kyqglcppvp rsqgdfdpgs kfhvpanvpy vryfvsfiiq
1141 fqfhealcra aghtgplhkc diyqskeagk lladamklgy skpwpeamkl itgqpnmsas
1201 ammnyfkplt ewlvtenrrh getlgwpeyn wapntaraeg staesnrvnf lglylepqqa
1261 rvgqwvllfl gvallvatvg lahrlynirn hhslrrphrg pqfgsevelr hs
//
