LOCUS       WP_015882533            1109 aa            linear   BCT 11-DEC-2019
DEFINITION  carbamoyl-phosphate synthase large subunit [Beutenbergia cavernae].
ACCESSION   WP_015882533
VERSION     WP_015882533.1
KEYWORDS    RefSeq.
SOURCE      Beutenbergia cavernae
  ORGANISM  Beutenbergia cavernae
            Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
            Beutenbergiaceae; Beutenbergia.
REFERENCE   1  (residues 1 to 1109)
  AUTHORS   Thoden,J.B., Huang,X., Kim,J., Raushel,F.M. and Holden,H.M.
  TITLE     Long-range allosteric transitions in carbamoyl phosphate synthetase
  JOURNAL   Protein Sci. 13 (9), 2398-2405 (2004)
   PUBMED   15322282
REFERENCE   2  (residues 1 to 1109)
  AUTHORS   Miles,B.W., Thoden,J.B., Holden,H.M. and Raushel,F.M.
  TITLE     Inactivation of the amidotransferase activity of carbamoyl
            phosphate synthetase by the antibiotic acivicin
  JOURNAL   J. Biol. Chem. 277 (6), 4368-4373 (2002)
   PUBMED   11729189
REFERENCE   3  (residues 1 to 1109)
  AUTHORS   Thoden,J.B., Raushel,F.M., Benning,M.M., Rayment,I. and Holden,H.M.
  TITLE     The structure of carbamoyl phosphate synthetase determined to 2.1 A
            resolution
  JOURNAL   Acta Crystallogr. D Biol. Crystallogr. 55 (Pt 1), 8-24 (1999)
   PUBMED   10089390
REFERENCE   4  (residues 1 to 1109)
  AUTHORS   Thoden,J.B., Holden,H.M., Wesenberg,G., Raushel,F.M. and Rayment,I.
  TITLE     Structure of carbamoyl phosphate synthetase: a journey of 96 A from
            substrate to product
  JOURNAL   Biochemistry 36 (21), 6305-6316 (1997)
   PUBMED   9174345
REFERENCE   5  (residues 1 to 1109)
  AUTHORS   Trotta,P.P., Pinkus,L.M., Haschemeyer,R.H. and Meister,A.
  TITLE     Reversible dissociation of the monomer of glutamine-dependent
            carbamyl phosphate synthetase into catalytically active heavy and
            light subunits
  JOURNAL   J. Biol. Chem. 249 (2), 492-499 (1974)
   PUBMED   4358555
REFERENCE   6  (residues 1 to 1109)
  AUTHORS   Khedouri,E., Anderson,P.M. and Meister,A.
  TITLE     Selective inactivation of the glutamine binding site of Escherichia
            coli carbamyl phosphate synthetase by
            2-amino-4-oxo-5-chloropentanoic acid
  JOURNAL   Biochemistry 5 (11), 3552-3557 (1966)
   PUBMED   5339592
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF003671.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK05294
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1109
                     /organism="Beutenbergia cavernae"
                     /db_xref="taxon:84757"
     gene            1..1109
                     /gene="carB"
     Protein         1..1109
                     /product="carbamoyl-phosphate synthase large subunit"
                     /EC_number="6.3.5.5"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006807 - nitrogen compound metabolic
                     process [Evidence IEA]"
                     /calculated_mol_wt=118324
     Region          1..1095
                     /region_name="carB"
                     /note="carbamoyl-phosphate synthase large subunit;
                     PRK05294"
                     /db_xref="CDD:235393"
ORIGIN      
        1 mprrtdltsv lvigsgpivi gqaaefdysg tqacrvlree glrvilvnsn patimtdpef
       61 adatyvepit pevvasiiak erpdallptl ggqtalntai alheagvlae ydveligani
      121 eaihlaedrd qfkgvvercg aesarshiah tieevleaar dlgyplvvrp sftmgglgsg
      181 iaydeadlrr iagaglhysp ttevlleesi lgwkeyelel mrdrndnvvv vcsienvdpv
      241 gvhtgdsitv apaltltdre yqrlrdvgia virevgvdtg gcniqfavhp dtgrvvviem
      301 nprvsrssal askatgfpia kiaarlavgy tldeipndit gstpasfept ldyvvvkvpr
      361 fafekfpaad plltttmksv geamalgrnf tealqkamrs idkagstfhw rgqapdpert
      421 aalvdaartp tegrlvqvqq airggatlee lfeataidpw fldqlfllee vagrlaavda
      481 ldagvlalak rhgfsdaqva eirdlgeatv reirhayglr pvyktvdtca aefeartpyh
      541 yssydaetev qprdrpavli lgsgpnrigq giefdyscvh aalalkgeye tvmvncnpet
      601 vstdydtadr lyfepltfed vlevyhaela vgpvagiivq lggqtplsla trladaglpi
      661 wgtppeaida aedrgvfgev lvaaglpapa fgtatslaqa ravadrigyp vlvrpsyvlg
      721 grgmeivydv eqltdyvrra tptdgpadap vfaspvlidr fldeaieidv dalydghelf
      781 lggvmehiee agihsgdsac vlppvtlsrr eierirtste aiargvgvrg llnvqfalss
      841 dvlyvleanp rasrtvpfva katgvplaka asllmagati adlrasghlp avdgtyahps
      901 spvavkeavl pfkrfrtrag tvvdtvlgpe mrstgevmgy dvdvpaafak sqaaaygglp
      961 tsgrvfvsva drdkrsivfp varlvelgfe ilattgtadv lrrygidsrv vrkasdgrgp
     1021 dgeltvvdli tageidmvvn tpngqgarad gydirtatta adkpivtttq qfaaavlgie
     1081 airrgpfava slqehdaara aretegvha
//