LOCUS       WP_062706185            1273 aa            linear   BCT 28-NOV-2019
DEFINITION  multifunctional oxoglutarate decarboxylase/oxoglutarate
            dehydrogenase thiamine pyrophosphate-binding
            subunit/dihydrolipoyllysine-residue succinyltransferase subunit
            [Streptomyces regalis].
ACCESSION   WP_062706185
VERSION     WP_062706185.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces regalis
  ORGANISM  Streptomyces regalis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (residues 1 to 1273)
  AUTHORS   Tian,J., Bryk,R., Itoh,M., Suematsu,M. and Nathan,C.
  TITLE     Variant tricarboxylic acid cycle in Mycobacterium tuberculosis:
            identification of alpha-ketoglutarate decarboxylase
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 102 (30), 10670-10675 (2005)
   PUBMED   16027371
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF008907.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK12270
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Streptomyces regalis"
                     /db_xref="taxon:68262"
     Protein         1..1273
                     /product="multifunctional oxoglutarate
                     decarboxylase/oxoglutarate dehydrogenase thiamine
                     pyrophosphate-binding subunit/dihydrolipoyllysine-residue
                     succinyltransferase subunit"
                     /EC_number="4.1.1.71"
                     /GO_function="GO:0004591 - oxoglutarate dehydrogenase
                     (succinyl-transferring) activity [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /calculated_mol_wt=138986
     Region          23..1273
                     /region_name="kgd"
                     /note="multifunctional oxoglutarate
                     decarboxylase/oxoglutarate dehydrogenase thiamine
                     pyrophosphate-binding subunit/dihydrolipoyllysine-residue
                     succinyltransferase subunit; PRK12270"
                     /db_xref="CDD:237030"
ORIGIN      
        1 mspqspsnss istdtdqagk npaaafgpne wlvdeiyqqy lqdpnsvdra wwdffadykp
       61 gapaasapag taaagaagtt tapaapaaap aapaapaapp apapapaapk paaaapaapa
      121 papaaakpaa papaakpaqp kkaepaaaaa egpefvtlrg psaavaknmn aslevptats
      181 vravpvkllf dnrivinnhl krarggkisf thligyamvq aikampsmny sfaekdgkpt
      241 lvkpehinfg laidlvkpng drqlvvagik kaetlnffef wqayedivrr ardgklgmdd
      301 ftgvtvsltn pgglgtvhsv prlmpgqsvi mgvgsmdypa efqgtsqdtl nklgiskvmt
      361 ltstydhrvi qgaasgeflr ivanlllges nfydeifeal ripyepvrwl kdidashddd
      421 vtkaarvfel ihsyrvrghv madtdpleyr qrkhpdldit ehgltlwdle refavggfsg
      481 kslmklrdil gvlrdsycrt tgiefmhiqd pkqrkwiqdr ierphtkper eeqlrilrrl
      541 naaeafetfl qtkyvgqkrf sleggesvip lldavldsaa esrldevvig mahrgrlnvl
      601 anivgksyaq ifrefegnld pksmhgsgdv kyhlgaqgif tgldgeqitv slaanpshle
      661 tvdpviegia rakqdiinkg gtdftvlpva lhgdaafagq gvvaetlnms qlrgyrtggt
      721 vhivinnqvg ftaapessrs smyatdvarm ieapifhvng ddpeavvrva rlafefrqaf
      781 nkdvvidlic yrrrghnesd npaftqplmy dlidkkrsvr klytesligr gditleeaeq
      841 alqdyqgqle kvftevreav saqpaagpvs dpqaefpvav htaissevvk riaesqvnip
      901 dtfhvhprll pqlqrratmv edgtidwgmg etlavgslll egtpvrlsgq dsqrgtfgqr
      961 havlinretg eeytplqyla edqarynvyn sllseyavmg feygyslarp dalvmweaqf
     1021 gdfvngaqtv vdeyisaaeq kwgqlsgvtl llphgyegqg pdhssarver flqlcaqnnm
     1081 tvamptlpsn yfhllrwqvh nphhkplvvf tpksmlrlka aaskteefts gqfrpvigda
     1141 tvdpaavrkv vfvagklyyd leaerqkrgv tdtaiirier lyplpgaeiq aeiakyanae
     1201 kylwaqeepa nqgawpfial nlidhldlav gadiphgerl rrisrphgss pavgsakrhq
     1261 aeqeqlvrev fea
//