LOCUS       WP_068554889             215 aa            linear   BCT 17-FEB-2025
DEFINITION  helix-turn-helix transcriptional regulator [Thermotalea
            metallivorans].
ACCESSION   WP_068554889
VERSION     WP_068554889.1
KEYWORDS    RefSeq.
SOURCE      Thermotalea metallivorans
  ORGANISM  Thermotalea metallivorans
            Bacteria; Bacillati; Bacillota; Clostridia; Peptostreptococcales;
            Thermotaleaceae; Thermotalea.
REFERENCE   1  (residues 1 to 215)
  AUTHORS   Stuffle,E.C., Johnson,M.S. and Watts,K.J.
  TITLE     PAS domains in bacterial signal transduction
  JOURNAL   Curr Opin Microbiol 61, 8-15 (2021)
   PUBMED   33647528
REFERENCE   2  (residues 1 to 215)
  AUTHORS   Henry,J.T. and Crosson,S.
  TITLE     Ligand-binding PAS domains in a genomic, cellular, and structural
            context
  JOURNAL   Annu Rev Microbiol 65, 261-286 (2011)
   PUBMED   21663441
REFERENCE   3  (residues 1 to 215)
  AUTHORS   Aravind,L., Anantharaman,V., Balaji,S., Babu,M.M. and Iyer,L.M.
  TITLE     The many faces of the helix-turn-helix domain: transcription
            regulation and beyond
  JOURNAL   FEMS Microbiol Rev 29 (2), 231-262 (2005)
   PUBMED   15808743
REFERENCE   4  (residues 1 to 215)
  AUTHORS   Hefti,M.H., Francoijs,K.J., de Vries,S.C., Dixon,R. and Vervoort,J.
  TITLE     The PAS fold. A redefinition of the PAS domain based upon
            structural prediction
  JOURNAL   Eur J Biochem 271 (6), 1198-1208 (2004)
   PUBMED   15009198
REFERENCE   5  (residues 1 to 215)
  AUTHORS   Rosinski,J.A. and Atchley,W.R.
  TITLE     Molecular evolution of helix-turn-helix proteins
  JOURNAL   J Mol Evol 49 (3), 301-309 (1999)
   PUBMED   10473770
REFERENCE   6  (residues 1 to 215)
  AUTHORS   Taylor,B.L. and Zhulin,I.B.
  TITLE     PAS domains: internal sensors of oxygen, redox potential, and light
  JOURNAL   Microbiol Mol Biol Rev 63 (2), 479-506 (1999)
   PUBMED   10357859
REFERENCE   7  (residues 1 to 215)
  AUTHORS   Ponting,C.P. and Aravind,L.
  TITLE     PAS: a multifunctional domain family comes to light
  JOURNAL   Curr Biol 7 (11), R674-R677 (1997)
   PUBMED   9382818
REFERENCE   8  (residues 1 to 215)
  AUTHORS   Wintjens,R. and Rooman,M.
  TITLE     Structural classification of HTH DNA-binding domains and
            protein-DNA interaction modes
  JOURNAL   J Mol Biol 262 (2), 294-313 (1996)
   PUBMED   8831795
REFERENCE   9  (residues 1 to 215)
  AUTHORS   Brennan,R.G. and Matthews,B.W.
  TITLE     The helix-turn-helix DNA binding motif
  JOURNAL   J Biol Chem 264 (4), 1903-1906 (1989)
   PUBMED   2644244
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11459460
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..215
                     /organism="Thermotalea metallivorans"
                     /db_xref="taxon:520762"
     Protein         1..215
                     /product="helix-turn-helix transcriptional regulator"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription
                     factor activity [Evidence IEA]"
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0140110 - transcription regulator
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /calculated_mol_wt=23751
     Region          1..212
                     /region_name="YheO"
                     /note="Predicted transcriptional regulator YheO, contains
                     PAS and DNA-binding HTH domains [Transcription]; COG2964"
                     /db_xref="CDD:442204"
ORIGIN      
        1 msneihpilk smipivegia ktfgkncevv lhdfknfqss iiaienghvt grslgspmte
       61 vglqairkgn tndniinytg kstdgralks stmfikdene hvigclcinf dmselivaqn
      121 aiqeltqtes kedvkqndyl tnsvndvlss ivsntleelg kpvaymskde kvnivkkldd
      181 qgaflikgai dyvakvlcvs rytiynylde irvnk
//