LOCUS       XP_001243361            1271 aa            linear   PLN 02-MAY-2022
DEFINITION  histone-lysine N-methyltransferase, H3 lysine-4 specific
            [Coccidioides immitis RS].
ACCESSION   XP_001243361
VERSION     XP_001243361.1
DBLINK      BioProject: PRJNA16822
            BioSample: SAMN02953601
DBSOURCE    REFSEQ: accession XM_001243360.2
KEYWORDS    RefSeq.
SOURCE      Coccidioides immitis RS
  ORGANISM  Coccidioides immitis RS
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Onygenales; Onygenaceae;
            Coccidioides.
REFERENCE   1  (residues 1 to 1271)
  AUTHORS   Neafsey,D., Orbach,M., Henn,M.R., Cole,G.T., Galgiani,J.,
            Gardner,M.J., Kirkland,T.N., Taylor,J.W., Young,S.K., Zeng,Q.,
            Koehrsen,M., Alvarado,L., Berlin,A., Borenstein,D., Chapman,S.B.,
            Chen,Z., Engels,R., Freedman,E., Gellesch,M., Goldberg,J.,
            Griggs,A., Gujja,S., Heilman,E., Heiman,D., Howarth,C., Jen,D.,
            Larson,L., Mehta,T., Neiman,D., Park,D., Pearson,M., Richards,J.,
            Roberts,A., Saif,S., Shea,T., Shenoy,N., Sisk,P., Stolte,C.,
            Sykes,S., Walk,T., White,J., Yandava,C., Haas,B., Nusbaum,C. and
            Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease.
  TITLE     Annotation of Coccidioides immitis strain RS
  JOURNAL   Unpublished
REFERENCE   2  (residues 1 to 1271)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 1271)
  AUTHORS   Neafsey,D., Orbach,M.J., Cole,G.T., Galgiani,J.N., Gardner,M.J.,
            Kirkland,T.N., Taylor,J.W., Henn,M., Young,S.K., Kodira,C.D.,
            Zeng,Q., Koehrsen,M., Alvarado,L., Berlin,A., Borenstein,D.,
            Chen,Z., Engels,R., Freedman,E., Gellesch,M., Goldberg,J.,
            Griggs,A., Gujja,S., Heiman,D., Hepburn,T., Howarth,C., Jen,D.,
            Larson,L., Lewis,B., Mehta,T., Park,D., Pearson,M., Roberts,A.,
            Saif,S., Shea,T., Shenoy,N., Sisk,P., Stolte,C., Sykes,S., Walk,T.,
            White,J., Yandava,C., Galagan,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform
  TITLE     Direct Submission
  JOURNAL   Submitted (27-MAR-2009) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to EAS31778.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..1271
                     /organism="Coccidioides immitis RS"
                     /strain="RS"
                     /db_xref="taxon:246410"
                     /chromosome="Unknown"
     Protein         1..1271
                     /product="histone-lysine N-methyltransferase, H3 lysine-4
                     specific"
                     /calculated_mol_wt=141475
     Region          267..360
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     Region          467..535
                     /region_name="SET_assoc"
                     /note="Histone lysine methyltransferase SET associated;
                     pfam11767"
                     /db_xref="CDD:432058"
     Region          953..1123
                     /region_name="N-SET"
                     /note="COMPASS (Complex proteins associated with Set1p)
                     component N; pfam11764"
                     /db_xref="CDD:432057"
     Region          1117..1267
                     /region_name="SET_SET1"
                     /note="SET domain (including post-SET domain) found in
                     catalytic component of the Saccharomyces cerevisiae
                     COMPASS complex and similar proteins; cd20072"
                     /db_xref="CDD:380998"
     Site            order(1138..1141,1158,1184..1189,1203..1208,1216..1218,
                     1227,1243..1248,1258..1261)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380998"
     Site            order(1138..1141,1184,1204..1208,1245,1258..1261)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380998"
     Site            order(1210,1259,1261,1266)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:380998"
     CDS             1..1271
                     /locus_tag="CIMG_07257"
                     /coded_by="XM_001243360.2:405..4220"
                     /db_xref="GeneID:4562336"
ORIGIN      
        1 msrapagfad ffptapsvlq kkrskaaqdr haantpkaad plpnlglsst pdikggvgts
       61 adnpvravge rsaettlalg dtngatssss lstgssgffs asappgvakp ngisscaltp
      121 ltntdssppc kiesplgsks gstdaapqla ptceahggpe pvtitplhtp ptprvqarpa
      181 nsevkghkit ydpdldrkfp skarrrkpqy etfgvddekd pppcdprmai anytrgaack
      241 qktkyrptpy ilrpwaydpt tsvgpgpptq ivvtgfdplt piaaisalfs sfgdigeinn
      301 rtdpmtgrfl gvcsikykds rafrggisls asqavrrayl eckkeqrigt rrirveldrn
      361 gvvsgrmvak litaqkaefp sleesrkesv gdndnrlpig dgakkdneqs kdnlppstap
      421 kgpsgrsslh psllapdgpr avlkspvpsr ieetpilqqi krdpyifiah cyvpvlsttv
      481 phlerrlkly dwkavrcdkt gyyiifensr rgeleaercy rmchmtalft yvmnmecqpy
      541 gnpnyersps perikaekre kakrerlhre meldieeekr lrvenldpar ealsvliiel
      601 rdkllddvks rvaapalydf lepdrhnakr qqlgipapeg tgrpsfrida stdgtvvhsq
      661 pdaysrhhrp ggvsslnvla lprirkvkgf eqgnavyide rrrakprkre frplyhrlqq
      721 lheiedsddd qqvsfardte evesrplsrl ssesaesdne ddlmrkspsl ldakpldvpl
      781 peseslaggi eqsglpdrek siieelergi ntlptsskkr krlieelatr kkrkevdnlf
      841 eldakplesl veetaqealp adstdalrtv tpvlkdkkrk vkgqsgkqif eerqapkrke
      901 idstqpllfe esvellpege ieisepaiee lkpevewgvs tdeprptaed ddtivldldg
      961 wqslikdded inflkkalse hlaadignla awtwkhkeik ainrggdrgp vhsetridgy
     1021 yvpnpsgsar tegrkrires ekskylphri kvqkareerl akakndphaa aaeaarllaa
     1081 kslskstsrs trvnnrrlia dinaqkqalp mqngdsdvlr fnqlkkrkkp vrfarsaihn
     1141 wglyaeenis andmiieyvg ekvrqqvadm rerrylksgi gssylfride ntvidatkrg
     1201 giarfinhsc tpnctakiik vdgskriviy alrdidrdee ltydykfere wdsddripcl
     1261 cgsagckgfl n
//