LOCUS       XP_001464885             470 aa            linear   INV 16-JUL-2015
DEFINITION  putative citrate synthase [Leishmania infantum JPCM5].
ACCESSION   XP_001464885
VERSION     XP_001464885.1
DBLINK      BioProject: PRJNA19187
DBSOURCE    REFSEQ: accession XM_001464848.1
KEYWORDS    RefSeq.
SOURCE      Leishmania infantum JPCM5
  ORGANISM  Leishmania infantum JPCM5
            Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
            Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
REFERENCE   1
  AUTHORS   Rogers,M.B., Hilley,J.D., Dickens,N.J., Wilkes,J., Bates,P.A.,
            Depledge,D.P., Harris,D., Her,Y., Herzyk,P., Imamura,H., Otto,T.D.,
            Sanders,M., Seeger,K., Dujardin,J.C., Berriman,M., Smith,D.F.,
            Hertz-Fowler,C. and Mottram,J.C.
  TITLE     Chromosome and gene copy number variation allow major structural
            change between species and strains of Leishmania
  JOURNAL   Genome Res. 21 (12), 2129-2142 (2011)
   PUBMED   22038252
REFERENCE   2
  AUTHORS   Peacock,C.S., Seeger,K., Harris,D., Murphy,L., Ruiz,J.C.,
            Quail,M.A., Peters,N., Adlem,E., Tivey,A., Aslett,M., Kerhornou,A.,
            Ivens,A., Fraser,A., Rajandream,M.A., Carver,T., Norbertczak,H.,
            Chillingworth,T., Hance,Z., Jagels,K., Moule,S., Ormond,D.,
            Rutter,S., Squares,R., Whitehead,S., Rabbinowitsch,E.,
            Arrowsmith,C., White,B., Thurston,S., Bringaud,F., Baldauf,S.L.,
            Faulconbridge,A., Jeffares,D., Depledge,D.P., Oyola,S.O.,
            Hilley,J.D., Brito,L.O., Tosi,L.R., Barrell,B., Cruz,A.K.,
            Mottram,J.C., Smith,D.F. and Berriman,M.
  TITLE     Comparative genomic analysis of three Leishmania species that cause
            diverse human disease
  JOURNAL   Nat. Genet. 39 (7), 839-847 (2007)
   PUBMED   17572675
REFERENCE   3  (residues 1 to 470)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JUL-2015) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   4  (residues 1 to 470)
  AUTHORS   Aslett,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-JAN-2011) to the INSDC. Aslett M., Pathogen
            Sequencing Unit, Wellcome Trust Sanger Institute, Wellcome Trust
            Genome Campus, Hinxton, Cambridge, Cambridgeshire, CB10 1SA, UNITED
            KINGDOM
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to CAM67122.
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Leishmania infantum JPCM5"
                     /strain="JPCM5"
                     /db_xref="taxon:435258"
                     /chromosome="18"
     Protein         1..470
                     /product="putative citrate synthase"
                     /calculated_mol_wt=52061
     Region          25..461
                     /region_name="ScCS-like"
                     /note="Saccharomyces cerevisiae (Sc) citrate synthase
                     (CS)-like. CS catalyzes the condensation of acetyl
                     coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate
                     and coenzyme A (CoA), the first step in the citric acid
                     cycle (TCA or Krebs cycle). Some CS...; cd06103"
                     /db_xref="CDD:99857"
     Site            order(63..64,67..73,160,164,167,261,266,269..270,273..274,
                     277..279,283,290..291,294..296,352,449..457)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:99857"
     Site            order(65,261,265,295..298,300,303,345..352,355,360,401,
                     404,406,428,432,449,452)
                     /site_type="active"
                     /db_xref="CDD:99857"
     Site            order(65,295..297,300,303,345..352,355,401,404,406,449)
                     /site_type="other"
                     /note="coenzyme A binding site [chemical binding]"
                     /db_xref="CDD:99857"
     Site            order(65,261,265,296..297,345..346,348..352,360,404,432)
                     /site_type="other"
                     /note="citrylCoA binding site [chemical binding]"
                     /db_xref="CDD:99857"
     Site            order(261,265,297..298,351..352,360,406,428,432,452)
                     /site_type="other"
                     /note="oxalacetate/citrate binding site [chemical
                     binding]"
                     /db_xref="CDD:99857"
     Site            order(297,351,406)
                     /site_type="active"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:99857"
     CDS             1..470
                     /locus_tag="LINJ_18_0690"
                     /old_locus_tag="LinJ18_0690"
                     /coded_by="XM_001464848.1:1..1413"
                     /db_xref="GeneID:5068291"
                     /db_xref="GOA:A4HXU4"
                     /db_xref="InterPro:IPR002020"
                     /db_xref="InterPro:IPR016141"
                     /db_xref="InterPro:IPR016142"
                     /db_xref="InterPro:IPR016143"
                     /db_xref="InterPro:IPR019810"
                     /db_xref="UniProtKB/Swiss-Prot:A4HXU4"
ORIGIN      
        1 mralrcsiir gvaglrmass vldemkeqml rrskedhkki gdlrkkhghe klcdatidav
       61 yggmrgitgl vyepslldsa egirfrglti lecqemlpka pggkeplpea mfwllmtgev
      121 pteeqargln aelhrrvdpe aiaaaqkaia alpknahpmt afsvgvlalq tyskfaaaya
      181 agksnkktyw eyaledsldm lartpavaam iynretkgqv elaapsnsdl dwaanfakml
      241 gfqdeefrec mrlylsvhad heggnvsaht ttlvasalsd pylafsagln glagplhgla
      301 nqevlkylfs mqervkadgv nvhdeaalek altkytwell nsgqvvpgyg havlrkvdpr
      361 ytcqrnfclr hnfqddlfkl vntiymimpg ilkehgktkn pypnvdahsg vllqhyglte
      421 qnyytvlfgl srqmgvlagv vwdrlqgrpl erpksittem lakkylcnsl
//