LOCUS       XP_006236465             746 aa            linear   ROD 11-JUN-2023
DEFINITION  histone-lysine N-methyltransferase EZH2 isoform X2 [Rattus
            norvegicus].
ACCESSION   XP_006236465
VERSION     XP_006236465.1
DBLINK      BioProject: PRJNA677964
DBSOURCE    REFSEQ: accession XM_006236403.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051339.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..746
                     /organism="Rattus norvegicus"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /sex="male"
                     /tissue_type="kidney"
                     /country="USA: Wisconsin, Milwaukee, Medical College of
                     Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     Protein         1..746
                     /product="histone-lysine N-methyltransferase EZH2 isoform
                     X2"
                     /calculated_mol_wt=85120
     Region          39..68
                     /region_name="EZH2_WD-Binding"
                     /note="WD repeat binding protein EZH2; pfam11616"
                     /db_xref="CDD:431961"
     Region          158..249
                     /region_name="PRC2_HTH_1"
                     /note="Polycomb repressive complex 2 tri-helical domain;
                     pfam18118"
                     /db_xref="CDD:436286"
     Region          559..590
                     /region_name="preSET_CXC"
                     /note="CXC domain; pfam18264"
                     /db_xref="CDD:408079"
     Region          609..728
                     /region_name="SET_EZH2"
                     /note="SET domain found in enhancer of zeste homolog 2
                     (EZH2) and similar proteins; cd19218"
                     /db_xref="CDD:380995"
     Site            order(613,615..618,620,624,627,629,679..680,683,703,719)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:380995"
     Site            order(621..624,641,648,651..652,655,659,662..668,685..689,
                     697,724,726..727)
                     /site_type="active"
                     /db_xref="CDD:380995"
     Site            order(623..624,657..658,661,663,665,678,685..689,726)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380995"
     Site            order(623..624,657..658,661,663,665,678,685..688)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:380995"
     Site            order(641,648,651..652,655,659,664,666..668,697,724,
                     726..728)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:380995"
     CDS             1..746
                     /gene="Ezh2"
                     /coded_by="XM_006236403.4:248..2488"
                     /db_xref="GeneID:312299"
                     /db_xref="RGD:1595860"
ORIGIN      
        1 mgqtgkksek gpvcwrkrvk seymrlrqlk rfrradevkt mfssnrqkil ertetlnqew
       61 kqrriqpvhi mtsvsslrgt recsvtsdld fpaqviplkt lnavasvpim yswsplqqnf
      121 mvedetvlhn ipymgdevld qdgtfieeli knydgkvhgd recgfindei fvelvnalgq
      181 yndddddddg ddpdereekq kdlddsrddk etcpprkfpa dkifeaissm fpdkgtaeel
      241 kekykelteq qlpgalppec tpnidgpnak svqreqslhs fhtlfcrrcf kydcflhpfh
      301 atpntykrkn tetaldnkpc gpqcyqhleg akefaaalta eriktppkrp ggrrrgrlpn
      361 nssrpstpti svleskdtds dreagtetgg enndkeeeek kdetssssea nsrcqtpikm
      421 kpnieppenv ewsgaeasmf rvligtyydn fcaiarligt ktcrqvyefr vkessiiapv
      481 ptedvdtppr kkkrkhrlwa ahcrkiqlkk dgssnhvyny qpcdhprqpc dsscpcviaq
      541 nfcekfcqcs secqnrfpgc rckaqcntkq cpcylavrec dpdlcltcga adhwdsknvs
      601 ckncsiqrgs kkhlllapsd vagwgifikd pvqknefise ycgeiisqde adrrgkvydk
      661 ymcsflfnln ndfvvdatrk gnkirfanhs vnpncyakvm mvngdhrigi fakraiqtge
      721 elffdyrysq adalkyvgie remeip
//