LOCUS       XP_008757141            1499 aa            linear   ROD 11-JUN-2023
DEFINITION  rho GTPase-activating protein 35 isoform X1 [Rattus norvegicus].
ACCESSION   XP_008757141
VERSION     XP_008757141.1
DBLINK      BioProject: PRJNA677964
DBSOURCE    REFSEQ: accession XM_008758919.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051336.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1499
                     /organism="Rattus norvegicus"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="kidney"
                     /country="USA: Wisconsin, Milwaukee, Medical College of
                     Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     Protein         1..1499
                     /product="rho GTPase-activating protein 35 isoform X1"
                     /calculated_mol_wt=170350
     Region          <158..250
                     /region_name="RAS"
                     /note="Ras subfamily of RAS small GTPases; smart00173"
                     /db_xref="CDD:214541"
     Region          261..340
                     /region_name="RhoGAP-FF1"
                     /note="p190-A and -B Rho GAPs FF domain; pfam16512"
                     /db_xref="CDD:435388"
     Region          371..422
                     /region_name="FF"
                     /note="Contains two conserved F residues; smart00441"
                     /db_xref="CDD:128718"
     Region          431..483
                     /region_name="FF"
                     /note="Contains two conserved F residues; smart00441"
                     /db_xref="CDD:128718"
     Region          486..539
                     /region_name="FF"
                     /note="Contains two conserved F residues; smart00441"
                     /db_xref="CDD:128718"
     Region          558..1251
                     /region_name="RhoGAP_pG1_pG2"
                     /note="p190RhoGAP, pG1 and pG2 domains; pfam19518"
                     /db_xref="CDD:437350"
     Region          1247..1431
                     /region_name="RhoGAP_p190"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of p190-like proteins. p190, also
                     named RhoGAP5, plays a role in neuritogenesis and axon
                     branch stability. p190 shows a preference for Rho, over
                     Rac and Cdc42, and consists of an...; cd04373"
                     /db_xref="CDD:239838"
     Site            order(1284,1322,1326,1395,1398..1399,1422)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239838"
     Site            1284
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239838"
     CDS             1..1499
                     /gene="Arhgap35"
                     /gene_synonym="Grlf1; p190RhoGAP"
                     /coded_by="XM_008758919.2:315..4814"
                     /db_xref="GeneID:306400"
                     /db_xref="RGD:1308738"
ORIGIN      
        1 mmmarkqdvr iptynisvvg lsgtekekgq cgigksclcn rfvrpsadef hldhtsvlst
       61 sdfggrvvnn dhflywgevs rsledcveck mhiveqtefi ddqtfqphrs talqpyikra
      121 aatklasaek lmyfctdqlg leqdfeqkqm pdgkllvdgf llgidvsrgm nrnfddqlkf
      181 vsnlynqlak tkkpivivlt kcdegveryi rdahtfalsk knlqvvetsa rsnvnvdlaf
      241 stlvqlidks rgktkiipyf ealkqqsqqi atakdkyewl vsrivkshne nwlsvsrkmq
      301 aspeyqdyvy legtqkakkl flqhihrlkh ehierrrkly laalplafea lipnldevdh
      361 lscikakkll etkpeflkwf vvleetpwde tshidnmene ripfdlmdtv paeqlyethl
      421 eklrnerkra emrrafkenl etspfitpgk pweearsfim nedfyqwlee svymdiygkh
      481 qkqiidrake efqellleys elfyelelda kpskekmgvi qdvlgeeqrf kalqklqaer
      541 dalilkhihf vyhptketcp scpacvdaki ehlissrfir psdrnqknsl sdpnidrinl
      601 vilgkdglar elaneiralc tnddkyvidg kmyelslrpi egnvrlpvns fqtptfqphg
      661 clclynskes lsyvvesiek srestlgrrd nhlvhlpltl ilvnkrgdts getlhsliqq
      721 gqqiasklqc vfldpasagi gygrninekq isqvlkglld skrnlnlvss tasikdladv
      781 dlrivmclmc gdpfsaddil spvlqsqtck sshcgssnsv llelpigvhk krielsvlsy
      841 hssfsirksr lvhgyivfys akrkaslaml raflcevqdi ipiqlvaltd gaidvldndl
      901 sreqltegee iaqeidgrft sipcsqpqhk lelfhpffkd vvekkniiea thmydnvaea
      961 cstteevfns pragsplcns nlqdseedve ppsyhlfred atlpslskdh skfsmelegn
     1021 dglsfimsnf esklnnkvpp pvkpkppvhf eitkdlsyld qghregqrks mssspwmpqd
     1081 gfdpsdyaep mdavvkprne eeniysvphd stqgkiitir ninkaqsngs gngsdsemdt
     1141 sslergrkvs avskpvlyrt rctrlgrfas yrtsfsvgsd delgpirkke edqasqgykg
     1201 dnavipyetd edprrrnilr slrrntkkpk pkprpsitka twesnyfgvp lttvvtpekp
     1261 ipifiercie yieatglste giyrvsgnks emeslqrqfd qdhnldlaek dftvntvaga
     1321 mksffselpd plvpysmqid lveahkindr eqklhalkev lkkfpkenhe vfkyvishln
     1381 rvshnnkvnl mtsenlsicf wptlmrpdfs smdaltatrs yqtiielfiq qcpfffynrp
     1441 iseppgaapg spsamaptvp fltstpatsq psppqspppt pqspmqplls sqlqaehtl
//