GenomeNet

Database: RefSeq
Entry: XP_011531985
LinkDB: XP_011531985
Original site: XP_011531985 
LOCUS       XP_011531985            2758 aa            linear   PRI 26-MAR-2018
DEFINITION  inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011531985
VERSION     XP_011531985.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011533683.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Homo sapiens Annotation Release 109
            Annotation Version          :: 109
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.0
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2758
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     Protein         1..2758
                     /product="inositol 1,4,5-trisphosphate receptor type 1
                     isoform X2"
                     /calculated_mol_wt=313800
     Region          4..225
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:285871"
     Region          231..287
                     /region_name="MIR"
                     /note="Domain in ryanodine and inositol trisphosphate
                     receptors and protein O-mannosyltransferases; smart00472"
                     /db_xref="CDD:197746"
     Region          232..433
                     /region_name="MIR"
                     /note="MIR domain; pfam02815"
                     /db_xref="CDD:280906"
     Region          294..>321
                     /region_name="MIR"
                     /note="Domain in ryanodine and inositol trisphosphate
                     receptors and protein O-mannosyltransferases; smart00472"
                     /db_xref="CDD:197746"
     Region          476..665
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:279676"
     Region          1209..1340
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:279676"
     Region          1973..2078
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:285630"
     Region          2350..2609
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:278921"
     CDS             1..2758
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /coded_by="XM_011533683.3:351..8627"
                     /db_xref="GeneID:3708"
                     /db_xref="HGNC:HGNC:6180"
                     /db_xref="MIM:147265"
ORIGIN      
        1 msdkmssflh igdicslyae gstngfistl glvddrcvvq petgdlnnpp kkfrdclfkl
       61 cpmnrysaqk qfwkaakpga nsttdavlln klhhaadlek kqnetenrkl lgtviqygnv
      121 iqllhlksnk yltvnkrlpa lleknamrvt ldeagnegsw fyiqpfyklr sigdsvvigd
      181 kvvlnpvnag qplhasshql vdnpgcnevn svncntswki vlfmkwsdnk ddilkggdvv
      241 rlfhaeqekf ltcdehrkkq hvflrttgrq satsatsska lwevevvqhd pcrggagywn
      301 slfrfkhlat ghylaaevdp dfeeeclefq psvdpdqdas rsrlrnaqek mvyslvsvpe
      361 gndissifel dpttlrggds lvprnsyvrl rhlctntwvh stnipidkee ekpvmlkigt
      421 spvkedkeaf aivpvspaev rdldfandas kvlgsiagkl ekgtitqner rsvtklledl
      481 vyfvtggtns gqdvlevvfs kpnrerqklm reqnilkqif kllqapftdc gdgpmlrlee
      541 lgdqrhapfr hicrlcyrvl rhsqqdyrkn qeyiakqfgf mqkqigydvl aedtitallh
      601 nnrkllekhi taaeidtfvs lvrknreprf ldylsdlcvs mnksipvtqe lickavlnpt
      661 nadilietkl vlsrfefegv sstgenalea gedeeevwlf wrdsnkeirs ksvrelaqda
      721 kegqkedrdv lsyyryqlnl farmcldrqy laineisgql dvdlilrcms denlpydlra
      781 sfcrlmlhmh vdrdpqeqvt pvkyarlwse ipseiaiddy dssgaskdei kerfaqtmef
      841 veeylrdvvc qrfpfsdkek nkltfevvnl arnliyfgfy nfsdllrltk illaildcvh
      901 vttifpiskm akgeenkgnn dveklkssnv mrsihgvgel mtqvvlrggg flpmtpmaaa
      961 pegnvkqaep ekedimvmdt klkiieilqf ilnvrldyri scllcifkre fdesnsqtse
     1021 tssgnssqeg psnvpgaldf ehieeqaegi fggseentpl dlddhggrtf lrvllhltmh
     1081 dypplvsgal qllfrhfsqr qevlqafkqv qllvtsqdvd nykqikqdld qlrsivekse
     1141 lwvykgqgpd etmdgasgen ehkkteegnn kpqkhestss ynyrvvkeil irlsklcvqe
     1201 sasvrksrkq qqrllrnmga havvlellqi pyekaedtkm qeimrlahef lqnfcagnqq
     1261 nqallhkhin lflnpgilea vtmqhifmnn fqlcseiner vvqhfvhcie thgrnvqyik
     1321 flqtivkaeg kfikkcqdmv maelvnsged vlvfyndras fqtliqmmrs erdrmdensp
     1381 lmyhihlvel lavctegknv yteikcnsll plddivrvvt hedcipevki ayinflnhcy
     1441 vdtevemkei ytsnhmwklf enflvdicra cnntsdrkha dsilekyvte ivmsivttff
     1501 sspfsdqstt lqtrqpvfvq llqgvfrvyh cnwlmpsqka svescirvls dvaksraiai
     1561 pvdldsqvnn lflkshsivq ktamnwrlsa rnaarrdsvl aasrdyrnii erlqdivsal
     1621 edrlrplvqa elsvlvdvlh rpellfpent darrkcesgg ficklikhtk qlleeneekl
     1681 cikvlqtlre mmtkdrgyge klisideldn aelppapdse nateelepsp plrqledhkr
     1741 gealrqvlvn ryygnvrpsg rresltsfgn gplsaggpgk pggggggsgs ssmsrgemsl
     1801 aevqchldke gasnlvidli mnassdrvfh esillaiall eggnttiqhs ffcrltedkk
     1861 sekffkvfyd rmkvaqqeik atvtvntsdl gnkkkddevd rdapsrkkak epttqiteev
     1921 rdqlleasaa trkafttfrr eadpddhyqp gegtqatadk akddlemsav itimqpilrf
     1981 lqllcenhnr dlqnflrcqn nktnynlvce tlqfldcicg sttgglgllg lyineknval
     2041 inqtleslte ycqgpchenq nciathesng idiitaliln dinplgkkrm dlvlelknna
     2101 sklllaimes rhdsenaeri lynmrpkelv evikkaymqg evefedgeng edgaasprnv
     2161 ghniyilahq larhnkelqs mlkpggqvdg dealefyakh taqieivrld rtmeqivfpv
     2221 psicefltke sklriyytte rdeqgskind fflrsedlfn emnwqkklra qpvlywcarn
     2281 msfwssisfn lavlmnllva ffypfkgvrg gtlephwsgl lwtamlisla ivialpkphg
     2341 iraliastil rlifsvglqp tlfllgafnv cnkiiflmsf vgncgtftrg yramvldvef
     2401 lyhllylvic amglfvheff yslllfdlvy reetllnvik svtrngrsii ltavlalilv
     2461 ylfsivgylf fkddfilevd rlpnetavpe tgeslasefl fsdvcrvesg encsspapre
     2521 elvpaeeteq dkehtcetll mcivtvlshg lrsgggvgdv lrkpskeepl faarviydll
     2581 fffmviiivl nlifgviidt fadlrsekqk keeilkttcf icglerdkfd nktvtfeehi
     2641 keehnmwhyl cfivlvkvkd steytgpesy vaemikernl dwfprmrams lvssdsegeq
     2701 nelrnlqekl estmklvtnl sgqlselkdq mteqrkqkqr igllghpphm nvnpqqpa
//
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