LOCUS YP_002790881 3419 aa linear VRL 01-AUG-2019
DEFINITION polyprotein [Zika virus].
ACCESSION YP_002790881
VERSION YP_002790881.1
DBLINK BioProject: PRJNA485481
DBSOURCE REFSEQ: accession NC_012532.1
KEYWORDS RefSeq.
SOURCE Zika virus
ORGANISM Zika virus
Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
Amarillovirales; Flaviviridae; Orthoflavivirus; Orthoflavivirus
zikaense.
REFERENCE 1 (residues 1 to 3419)
AUTHORS Kuno,G. and Chang,G.-J.J.
TITLE Full-length sequencing and genomic characterization of Bagaza,
Kedougou, and Zika viruses
JOURNAL Arch Virol. 152 (4), 687-696 (2007)
PUBMED 17195954
REFERENCE 2 (residues 1 to 3419)
AUTHORS Kuno,G. and Chang,G.J.
TITLE Biological transmission of arboviruses: reexamination of and new
insights into components, mechanisms, and unique traits as well as
their evolutionary trends
JOURNAL Clin. Microbiol. Rev. 18 (4), 608-637 (2005)
PUBMED 16223950
REFERENCE 3 (residues 1 to 3419)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (06-APR-2009) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 4 (residues 1 to 3419)
AUTHORS Kuno,G. and Chang,G.-J.J.
TITLE Direct Submission
JOURNAL Submitted (01-AUG-2006) Division of Vector-Borne Infect. Dis., CDC,
P.O. Box 2087, Fort Collins, CO 80522-2087, USA
REMARK Sequence update by submitter
REFERENCE 5 (residues 1 to 3419)
AUTHORS Kuno,G., Chang,G.-J.J. and Tsuchiya,K.R.
TITLE Direct Submission
JOURNAL Submitted (21-MAY-2004) Arbovirus Diseases Branch, Division of
Vector-Borne Infectious Diseases, Centers for Disease Control and
Prevention, P.O. Box 2087, Fort Collins, CO 80522, USA
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AAV34151.
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..3419
/organism="Zika virus"
/strain="MR 766"
/host="sentinel monkey"
/db_xref="taxon:64320"
/country="Uganda"
/note="mosquito-borne flavivirus"
Protein 1..3419
/product="polyprotein"
/calculated_mol_wt=378607
mat_peptide 1..122
/product="anchored capsid protein ancC"
/protein_id="YP_009227206.1"
/calculated_mol_wt=13562
mat_peptide 1..104
/product="capsid protein C"
/protein_id="YP_009227196.1"
/calculated_mol_wt=11862
Region 12..122
/region_name="Flavi_capsid"
/note="Flavivirus capsid protein C; pfam01003"
/db_xref="CDD:366413"
mat_peptide 123..290
/product="membrane glycoprotein precursor prM"
/protein_id="YP_009227197.1"
/calculated_mol_wt=19012
mat_peptide 123..215
/product="protein pr"
/protein_id="YP_009227207.1"
/calculated_mol_wt=10515
Region 127..203
/region_name="Flavi_propep"
/note="Flavivirus polyprotein propeptide; pfam01570"
/db_xref="CDD:366710"
mat_peptide 216..290
/product="membrane glycoprotein M"
/protein_id="YP_009227208.1"
/calculated_mol_wt=8515
Region 216..290
/region_name="Flavi_M"
/note="Flavivirus envelope glycoprotein M; cd17038"
/db_xref="CDD:341208"
Site order(216,218..227,229..231,233..234,243,273,284)
/site_type="other"
/note="glycoprotein E binding interface [polypeptide
binding]"
/db_xref="CDD:341208"
mat_peptide 291..790
/product="envelope protein E"
/protein_id="YP_009227198.1"
/calculated_mol_wt=54086
Region 292..588
/region_name="Flavi_glycoprot"
/note="Flavivirus glycoprotein, central and dimerization
domains; pfam00869"
/db_xref="CDD:395698"
Region 597..689
/region_name="Flavi_E_C"
/note="Immunoglobulin-like domain III (C-terminal domain)
of Flavivirus envelope glycoprotein E; cd12149"
/db_xref="CDD:213392"
Site order(602..603,605..606,613..614,661)
/site_type="other"
/note="homodimer interface [polypeptide binding]"
/db_xref="CDD:213392"
Site order(609,626,645..648,650)
/site_type="other"
/note="low pH domain interface [polypeptide binding]"
/db_xref="CDD:213392"
Site order(610,626,643..645,665)
/site_type="other"
/note="low pH trimer interface [polypeptide binding]"
/db_xref="CDD:213392"
Region 694..790
/region_name="flavi_E_stem"
/note="flavivirus envelope glycoprotein E, stem/anchor
domain; TIGR04240"
/db_xref="CDD:213897"
mat_peptide 791..1142
/product="nonstructural protein NS1"
/protein_id="YP_009227199.1"
/calculated_mol_wt=40079
Region 793..1144
/region_name="Flavi_NS1"
/note="Flavivirus non-structural Protein NS1; pfam00948"
/db_xref="CDD:279316"
mat_peptide 1143..1368
/product="nonstructural protein NS2A"
/protein_id="YP_009227200.1"
/calculated_mol_wt=23965
Region 1154..1303
/region_name="Flavi_NS2A"
/note="Flavivirus non-structural protein NS2A; pfam01005"
/db_xref="CDD:279359"
mat_peptide 1369..1498
/product="nonstructural protein NS2B"
/protein_id="YP_009227201.1"
/calculated_mol_wt=13777
Region 1373..1498
/region_name="Flavi_NS2B"
/note="Flavivirus non-structural protein NS2B; pfam01002"
/db_xref="CDD:279357"
mat_peptide 1499..2115
/product="nonstructural protein NS3"
/protein_id="YP_009227202.1"
/calculated_mol_wt=68413
Region 1516..1665
/region_name="Peptidase_S7"
/note="Peptidase S7, Flavivirus NS3 serine protease;
pfam00949"
/db_xref="CDD:395758"
Region 1684..1829
/region_name="Flavi_DEAD"
/note="Flavivirus DEAD domain; pfam07652"
/db_xref="CDD:400138"
Site order(1694..1700,1783..1784)
/site_type="other"
/note="ATP binding site [chemical binding]"
/db_xref="CDD:350689"
Region 1831..1973
/region_name="SF2_C_viral"
/note="C-terminal helicase domain of viral helicase;
cd18806"
/db_xref="CDD:350193"
Site order(1838,1843,1846..1847,1934..1936)
/site_type="other"
/note="homodimer interface [polypeptide binding]"
/db_xref="CDD:350193"
Site order(1957,1960)
/site_type="other"
/note="putative ATP binding site [chemical binding]"
/db_xref="CDD:350193"
mat_peptide 2116..2242
/product="nonstructural protein NS4A"
/protein_id="YP_009227203.1"
/calculated_mol_wt=13697
Region 2121..2265
/region_name="Flavi_NS4A"
/note="Flavivirus non-structural protein NS4A; pfam01350"
/db_xref="CDD:279666"
mat_peptide 2243..2265
/product="protein 2K"
/protein_id="YP_009227209.1"
/calculated_mol_wt=2369
mat_peptide 2266..2516
/product="nonstructural protein NS4B"
/protein_id="YP_009227204.1"
/calculated_mol_wt=26944
Region 2266..2508
/region_name="Flavi_NS4B"
/note="Flavivirus non-structural protein NS4B; pfam01349"
/db_xref="CDD:279665"
mat_peptide 2517..3419
/product="RNA-dependent RNA polymerase NS5"
/protein_id="YP_009227205.1"
/calculated_mol_wt=103016
Region 2527..2757
/region_name="capping_2-OMTase_Flaviviridae"
/note="Cap-0 specific (nucleoside-2'-O-)-methyltransferase
of flaviviridae; cd20761"
/db_xref="CDD:394920"
Site order(2529,2532..2533,2535,2666..2667,2731)
/site_type="other"
/note="nucleic acid substrate binding site [nucleotide
binding]"
/db_xref="CDD:394920"
Site order(2597..2599,2602..2603,2620..2621,2646..2647,
2662..2663)
/site_type="other"
/note="SAM binding site [chemical binding]"
/db_xref="CDD:394920"
Site order(2662,2698,2734)
/site_type="active"
/db_xref="CDD:394920"
Region 2768..3412
/region_name="Flavi_NS5"
/note="Flavivirus RNA-directed RNA polymerase; pfam00972"
/db_xref="CDD:366396"
CDS 1..3419
/gene="POLY"
/locus_tag="ZIKV_gp1"
/coded_by="NC_012532.1:107..10366"
/db_xref="GeneID:7751225"
ORIGIN
1 mknpkeeirr irivnmlkrg varvnplggl krlpaglllg hgpirmvlai laflrftaik
61 pslglinrwg svgkkeamei ikkfkkdlaa mlriinarke rkrrgadtsi giigllltta
121 maaeitrrgs ayymyldrsd agkaisfatt lgvnkchvqi mdlghmcdat msyecpmlde
181 gvepddvdcw cnttstwvvy gtchhkkgea rrsrravtlp shstrklqtr sqtwlesrey
241 tkhlikvenw ifrnpgfalv avaiawllgs stsqkviylv milliapays ircigvsnrd
301 fvegmsggtw vdvvlehggc vtvmaqdkpt vdielvtttv snmaevrsyc yeasisdmas
361 dsrcptqgea yldkqsdtqy vckrtlvdrg wgngcglfgk gslvtcakft cskkmtgksi
421 qpenleyrim lsvhgsqhsg migyetdedr akvevtpnsp raeatlggfg slgldceprt
481 gldfsdlyyl tmnnkhwlvh kewfhdiplp whagadtgtp hwnnkealve fkdahakrqt
541 vvvlgsqega vhtalagale aemdgakgrl fsghlkcrlk mdklrlkgvs yslctaaftf
601 tkvpaetlhg tvtvevqyag tdgpckipvq mavdmqtltp vgrlitanpv itestenskm
661 mleldppfgd syivigvgdk kithhwhrsg stigkafeat vrgakrmavl gdtawdfgsv
721 ggvfnslgkg ihqifgaafk slfggmswfs qiligtllvw lglntkngsi sltclalggv
781 miflstavsa dvgcsvdfsk ketrcgtgvf iyndveawrd rykyhpdspr rlaaavkqaw
841 eegicgissv srmenimwks vegelnaile engvqltvvv gsvknpmwrg pqrlpvpvne
901 lphgwkawgk syfvraaktn nsfvvdgdtl kecplehraw nsflvedhgf gvfhtsvwlk
961 vredyslecd pavigtavkg reaahsdlgy wiesekndtw rlkrahliem ktcewpksht
1021 lwtdgveesd liipkslagp lshhntregy rtqvkgpwhs eeleirfeec pgtkvyveet
1081 cgtrgpslrs ttasgrviee wccrectmpp lsfrakdgcw ygmeirprke pesnlvrsmv
1141 tagstdhmdh fslgvlvill mvqeglkkrm ttkiimstsm avlvvmilgg fsmsdlaklv
1201 ilmgatfaem ntggdvahla lvaafkvrpa llvsfifran wtpresmlla lascllqtai
1261 salegdlmvl ingfalawla iramavprtd nialpilaal tplargtllv awraglatcg
1321 gimllslkgk gsvkknlpfv malgltavrv vdpinvvgll lltrsgkrsw ppsevltavg
1381 licalaggfa kadiemagpm aavgllivsy vvsgksvdmy ieragditwe kdaevtgnsp
1441 rldvaldesg dfslveedgp pmreiilkvv lmaicgmnpi aipfaagawy vyvktgkrsg
1501 alwdvpapke vkkgettdgv yrvmtrrllg stqvgvgvmq egvfhtmwhv tkgaalrsge
1561 grldpywgdv kqdlvsycgp wkldaawdgl sevqllavpp gerarniqtl pgifktkdgd
1621 igavaldypa gtsgspildk cgrviglygn gvvikngsyv saitqgkree etpvecfeps
1681 mlkkkqltvl dlhpgagktr rvlpeivrea ikkrlrtvil aptrvvaaem eealrglpvr
1741 ymttavnvth sgteivdlmc hatftsrllq pirvpnynln imdeahftdp ssiaargyis
1801 trvemgeaaa ifmtatppgt rdafpdsnsp imdtevevpe rawssgfdwv tdhsgktvwf
1861 vpsvrngnei aacltkagkr viqlsrktfe tefqktknqe wdfvittdis emganfkadr
1921 vidsrrclkp vildgervil agpmpvthas aaqrrgrigr npnkpgdeym ygggcaetde
1981 ghahwlearm lldniylqdg liaslyrpea dkvaaiegef klrteqrktf velmkrgdlp
2041 vwlayqvasa gitytdrrwc fdgttnntim edsvpaevwt kygekrvlkp rwmdarvcsd
2101 haalksfkef aagkrgaalg vmealgtlpg hmterfqeai dnlavlmrae tgsrpykaaa
2161 aqlpetleti mllgllgtvs lgiffvlmrn kgigkmgfgm vtlgasawlm wlseiepari
2221 acvlivvfll lvvlipepek qrspqdnqma iiimvavgll glitanelgw lertkndiah
2281 lmgrreegat mgfsmdidlr pasawaiyaa lttlitpavq havttsynny slmamatqag
2341 vlfgmgkgmp fmhgdlgvpl lmmgcysqlt pltlivaiil lvahymylip glqaaaaraa
2401 qkrtaagimk npvvdgivvt didtmtidpq vekkmgqvll iavaissavl lrtawgwgea
2461 galitaatst lwegspnkyw nsstatslcn ifrgsylaga sliytvtrna glvkrrgggt
2521 getlgekwka rlnqmsalef ysykksgite vcreearral kdgvatggha vsrgsakirw
2581 leergylqpy gkvvdlgcgr ggwsyyaati rkvqevrgyt kggpgheepm lvqsygwniv
2641 rlksgvdvfh maaepcdtll cdigessssp eveetrtlrv lsmvgdwlek rpgafcikvl
2701 cpytstmmet merlqrrhgg glvrvplcrn sthemywvsg aksniiksvs ttsqlllgrm
2761 dgprrpvkye edvnlgsgtr avascaeapn mkiigrrier irnehaetwf ldenhpyrtw
2821 ayhgsyeapt qgsasslvng vvrllskpwd vvtgvtgiam tdttpygqqr vfkekvdtrv
2881 pdpqegtrqv mnivsswlwk elgkrkrprv ctkeefinkv rsnaalgaif eeekewktav
2941 eavndprfwa lvdrerehhl rgechscvyn mmgkrekkqg efgkakgsra iwymwlgarf
3001 lefealgfln edhwmgrens gggveglglq rlgyileemn rapggkmyad dtagwdtris
3061 kfdleneali tnqmeeghrt lalavikyty qnkvvkvlrp aeggktvmdi isrqdqrgsg
3121 qvvtyalntf tnlvvqlirn meaeevlemq dlwllrkpek vtrwlqsngw drlkrmavsg
3181 ddcvvkpidd rfahalrfln dmgkvrkdtq ewkpstgwsn weevpfcshh fnklylkdgr
3241 sivvpcrhqd eligrarvsp gagwsireta claksyaqmw qllyfhrrdl rlmanaicsa
3301 vpvdwvptgr ttwsihgkge wmttedmlmv wnrvwieend hmedktpvtk wtdipylgkr
3361 edlwcgslig hrprttwaen ikdtvnmvrr iigdeekymd ylstqvrylg eegstpgvl
//
