KEGG   PATHWAY: rn00350
Entry
rn00350                     Pathway                                

Name
Tyrosine metabolism
Class
Metabolism; Amino acid metabolism
Pathway map
rn00350  Tyrosine metabolism
rn00350

Module
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:rn00350]
M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:rn00350]
M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:rn00350]
M00533  Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:rn00350]
Other DBs
GO: 0006570
Reaction
R00031  1,2-benzenediol:oxygen oxidoreductase
R00042  4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
R00045  3,4-dihydroxy-L-phenylalanine:oxygen oxidoreductase
R00713  succinate-semialdehyde:NAD+ oxidoreductase
R00714  succinate-semialdehyde:NADP+ oxidoreductase
R00728  L-tyrosine phenol-lyase (deaminating; pyruvate-forming)
R00729  L-Tyrosine:oxygen oxidoreductase (deaminating)
R00731  L-Tyrosine:oxygen oxidoreductase
R00734  L-tyrosine:2-oxoglutarate aminotransferase
R00736  L-tyrosine carboxy-lyase (tyramine-forming)
R00737  L-tyrosine ammonia-lyase (trans-p-hydroxycinnamate-forming)
R00739  L-Tyrosine 2,3-aminomutase
R01085  3-fumarylpyruvate fumarylhydrolase
R01364  4-fumarylacetoacetate fumarylhydrolase
R01647  2,4-dihydroxyhept-2-enedioate succinate-semialdehyde-lyase (pyruvate-forming)
R01815  L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
R02075  3,4-Dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)
R02076  3,4-Dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)
R02077  3,4-Dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase
R02078  L-Tyrosine,L-dopa:oxygen oxidoreductase
R02080  3,4-Dihydroxy-L-phenylalanine carboxy-lyase
R02382  Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing)
R02384  S-Adenosyl-L-methionine:tyramine N-methyltransferase
R02489  Gentisate carboxy-lyase
R02514  4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (1-hydroxylating)
R02516  4-hydroxyphenylacetate,NADPH:oxygen oxidoreductase (1-hydroxylating)
R02518   
R02519  Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
R02520   
R02521  4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)
R02532  4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
R02533  S-Adenosyl-L-methionine:phenylethanolamine N-methyltransferase
R02534  S-Adenosyl-L-methionine:catechol O-methyltransferase
R02535  dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
R02655  Gentisate aldehyde:NAD+ oxidoreductase
R02656  Gentisate:oxygen 1,2-oxidoreductase (decyclizing)
R02657   
R02695  4-Hydroxyphenylacetaldehyde:NAD+ oxidoreductase
R02697  4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
R02698  4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)
R02699  4-Hydroxyphenylacetate:CoA ligase (AMP-forming)
R02919  4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
R02920  S-Adenosyl-L-methionine:catechol O-methyltransferase
R02962   
R03181  4-Maleylacetoacetate cis-trans-isomerase
R03208   
R03299  3-Hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)
R03300  3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
R03302  3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
R03303  3,4-Dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)
R03304  S-Adenosyl-L-methionine:catechol O-methyltransferase
R03306  4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating)
R03337  (R)-3-(4-hydroxyphenyl)lactate:NAD+ 2-oxidoreductase
R03339  (R)-3-(4-hydroxyphenyl)lactate:NADP+ 2-oxidoreductase
R03341  4-hydroxyphenylpyruvate carboxy-lyase
R03342  3-(4-Hydroxyphenyl)pyruvate keto-enol-isomerase
R03373  4-hydroxyphenyllactate:NAD+ oxidoreductase
R03374  caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyltransferase
R03539   
R03672   
R03673  L-Dopachrome delta7-delta2-isomerase
R03674   
R03868  3-Maleylpyruvate cis-trans-isomerase
R03943   
R03953   
R03973   
R04132   
R04134   
R04300  4-(2-Aminoethyl)-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
R04301  S-Adenosyl-L-methionine:catechol O-methyltransferase
R04304  4-Hydroxyphenylethanol:NAD+ oxidoreductase
R04379  5-Carboxymethyl-2-hydroxymuconate delta2,delta4-2-oxo,delta3-isomerase
R04380  5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase
R04418  5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase
R04419  5-carboxymethyl-2-hydroxymuconic-semialdehyde:NADP+ oxidoreductase
R04598  3,4-Dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)
R04599  3,4-Dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)
R04600  3,4-Dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)
R04601  3,4-Dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)
R04776  Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
R04777   
R04880  3,4-dihydroxyphenylethyleneglycol:NAD+ oxidoreductase
R04881  S-Adenosyl-L-methionine:catechol O-methyltransferase
R04882  3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
R04883  3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
R04884  5,6-dihydroxyindole:oxygen oxidoreductase
R04886   
R04887  S-Adenosyl-L-methionine:catechol O-methyltransferase
R04888  3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase
R04889  3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase
R04890  3-Methoxytyramine:oxygen oxidoreductase (deaminating) (copper-containing)
R04891  3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
R04892  3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
R04893  L-Normetanephrine:oxygen oxidoreductase (deaminating) (copper-containing)
R04894  L-Metanephrine:oxygen oxidoreductase (deaminating) (flavin-containing)
R05083  UDP-glucose:4-hydroxyphenylethanol 1-O-beta-D-glucosyltransferase
R06612   
R06897  2,4-dihydroxyhept-2-enedioate hydro-lyase
R08846  3,4-dihydroxy-L-phenylalanine ammonia-lyase (3,4-dihydroxyphenylpropanoate-forming)
R08847   
R08848   
R08849   
R08920  3,4-dihydroxy-L-phenylalanine:oxygen oxidoreductase (deaminating)
R08965  5,6-Dihydroxyindole-2-carboxylate:oxygen oxidoreductase
R09254  L-tyrosine:pyruvate aminotransferase
R09830  L-Tyrosine:NAD+ oxidoreductase (deaminating)
R11257  (2Z)-4,6-dioxohept-2-enedioate acylhydrolase
R11916  L-dopa carboxy-lyase (oxidative-deaminating)
R11917  L-tyrosine carboxy-lyase (oxidative-deaminating)
R12252  (R)-3-(4-hydroxyphenyl)lactate:NADP+ oxidoreductase
R12611  L-tyrosine:hydrogen-peroxide oxidoreductase (L-dopa-forming)
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
rn00020  Citrate cycle (TCA cycle)
rn00360  Phenylalanine metabolism
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00620  Pyruvate metabolism
rn00621  Dioxin degradation
rn00650  Butanoate metabolism
rn00940  Phenylpropanoid biosynthesis
rn00950  Isoquinoline alkaloid biosynthesis
KO pathway
ko00350   

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