KEGG   PATHWAY: rn00622
Entry
rn00622                     Pathway                                

Name
Xylene degradation
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
rn00622  Xylene degradation
rn00622

Module
M00419  Cymene degradation, p-cymene => p-cumate [PATH:rn00622]
M00537  Xylene degradation, xylene => methylbenzoate [PATH:rn00622]
M00539  Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate [PATH:rn00622]
M00551  Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol [PATH:rn00622]
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA [PATH:rn00622]
Other DBs
GO: 0042184
UMBBD: mxy oxy pxy pcy tol
Reaction
R00228  acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)
R00750  4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)
R02601  4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)
R04089  3-methylcatechol:oxygen 2,3-oxidoreductase(decyclizing)
R05138  2-hydroxy-6-oxohepta-2,4-dienoate acetylhydrolase
R05232  p-cumic alcohol:NAD+ oxidoreductase
R05235  p-cumic aldehyde:NAD+ oxidoreductase
R05240  cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase
R05247  4-isopropylbenzoate:oxygen 2,3-oxidoreductase
R05248   
R05266  p-cymene,ferredoxin:oxygen oxidoreductase (methyl-hydroxylating)
R05282  4-Methylbenzyl alcohol:NAD+ oxidoreductase
R05288  p-xylene, ferredoxin:oxygen oxidoreductase (methyl-hydroxylating)
R05289  p-Methylbenzaldehyde:NADP+ oxidoreductase
R05290   
R05291   
R05292  cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)
R05293  cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NADP+ oxidoreductase (decarboxylating)
R05295  4-methylcatechol:oxygen 2,3-oxidoreductase(decyclizing)
R05298  4-hydroxy-2-oxohexanoate pyruvate-lyase (propanal-forming)
R05309  1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)
R05314  1,2-Dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)
R05347   
R05348   
R05353  2-hydroxy-5-methyl-cis,cis-muconic semialdehyde:NAD+ 6-oxidoreductase
R05364  2-Hydroxy-6-oxo-7-methylocta-2,4-dienoate acylhydrolase
R05374  2-Oxo-5-methyl-cis-muconate carboxy-lyase
R05377  2-Hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate carboxy-lyase
R05389  2-Hydroxy-5-methyl-cis,cis-muconate 2-Oxo-5-methyl-cis-muconate isomerase
R05428   
R05442  o-Xylene, ferredoxin:oxygen oxidoreductase (methyl-hydroxylating)
R05443  m-xylene, ferredoxin:oxygen oxidoreductase (methyl-hydroxylating)
R05663   
R05664   
R05665   
R05864  4-Hydroxy-2-oxohexanoate hydro-lyase
R05865  2-Hydroxy-5-methyl-cis,cis-muconic-semialdehyde formylhydrolase
R09097  propanal:NAD+ oxidoreductase (CoA-propanoylating)
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00084  Acetaldehyde
C00100  Propanoyl-CoA
C00479  Propanal
C00596  2-Hydroxy-2,4-pentadienoate
C01454  Toluate
C02923  2,3-Dihydroxytoluene
C03589  4-Hydroxy-2-oxopentanoate
C06210  2-Hydroxy-6-keto-2,4-heptadienoate
C06575  p-Cymene
C06576  p-Cumic alcohol
C06577  4-Isopropylbenzaldehyde
C06578  p-Cumate
C06579  cis-2,3-Dihydroxy-2,3-dihydro-p-cumate
C06580  2,3-Dihydroxy-p-cumate
C06581  2-Hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate
C06582  2-Hydroxy-6-oxo-7-methylocta-2,4-dienoate
C06720  1,6-Dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate
C06729  cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate
C06730  4-Methylcatechol
C06731  1,2-Dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate
C06756  p-Xylene
C06757  4-Methylbenzyl alcohol
C06758  p-Tolualdehyde
C06760  2-Hydroxy-5-methyl-cis,cis-muconic semialdehyde
C06762  4-Hydroxy-2-oxohexanoic acid
C07208  m-Xylene
C07209  3-Methylbenzaldehyde
C07211  m-Methylbenzoate
C07212  o-Xylene
C07213  2-Methylbenzyl alcohol
C07214  2-Methylbenzaldehyde
C07215  o-Toluate
C07216  3-Methylbenzyl alcohol
C07478  2-Hydroxy-5-methyl-cis,cis-muconate
C07479  2-Oxo-5-methyl-cis-muconate
C11354  2-Hydroxy-cis-hex-2,4-dienoate
Reference
  Authors
Haddad S, Eby DM, Neidle EL.
  Title
Cloning and expression of the benzoate dioxygenase genes from Rhodococcus sp. strain 19070.
  Journal
Appl Environ Microbiol 67:2507-14 (2001)
DOI:10.1128/AEM.67.6.2507-2514.2001
Reference
PMID:7768806
  Authors
Kim E, Zylstra GJ
  Title
Molecular and biochemical characterization of two meta-cleavage dioxygenases involved in biphenyl and m-xylene degradation by Beijerinckia sp. strain B1.
  Journal
J Bacteriol 177:3095-103 (1995)
DOI:10.1128/JB.177.11.3095-3103.1995
Reference
  Authors
Morasch B, Schink B, Tebbe CC, Meckenstock RU
  Title
Degradation of o-xylene and m-xylene by a novel sulfate-reducer belonging to the genus Desulfotomaculum.
  Journal
Arch Microbiol 181:407-17 (2004)
DOI:10.1007/s00203-004-0672-6
Reference
PMID:9150211
  Authors
Eaton RW.
  Title
p-Cymene catabolic pathway in Pseudomonas putida F1: cloning and characterization of DNA encoding conversion of p-cymene to p-cumate.
  Journal
J Bacteriol 179:3171-80 (1997)
DOI:10.1128/JB.179.10.3171-3180.1997
Reference
PMID:8631713
  Authors
Eaton RW.
  Title
p-Cumate catabolic pathway in Pseudomonas putida Fl: cloning and characterization of DNA carrying the cmt operon.
  Journal
J Bacteriol 178:1351-62 (1996)
DOI:10.1128/JB.178.5.1351-1362.1996
Related
pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00623  Toluene degradation
rn00640  Propanoate metabolism
KO pathway
ko00622   

DBGET integrated database retrieval system