KEGG   PATHWAY: rn00730
Entry
rn00730                     Pathway                                

Name
Thiamine metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
rn00730  Thiamine metabolism
rn00730

Module
M00127  Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP [PATH:rn00730]
M00895  Thiamine biosynthesis, prokaryotes, AIR (+ DXP/glycine) => TMP/TPP [PATH:rn00730]
M00896  Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP [PATH:rn00730]
M00897  Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP [PATH:rn00730]
M00898  Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP [PATH:rn00730]
M00899  Thiamine salvage pathway, HMP/HET => TMP [PATH:rn00730]
Other DBs
GO: 0006772
Reaction
R00033  thiamine:oxygen 5-oxidoreductase
R00072  thiamine-aldehyde:oxygen 5-oxidoreductase
R00615  Thiamin diphosphate phosphohydrolase
R00616  ATP:thiamine-diphosphate phosphotransferase
R00617  ATP:thiamin-phosphate phosphotransferase
R00618  Thiamin-triphosphate phosphohydrolase
R00619  ATP:thiamine diphosphotransferase
R02133  Thiamin hydrolase
R02134  ATP:thiamine phosphotransferase
R02135  thiamin monophosphate phosphohydrolase
R02863  Thiamin:beta 2-methyl-4-aminopyrimidine-5-methenyltransferase
R03223  2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)-thiazole 2-methyl-4-aminopyridine-5-methenyltransferase
R03471  ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase
R03472  5-amino-1-(5-phospho-D-ribosyl)imidazole formate-lyase (decarboxylating, 4-amino-2-methyl-5-phosphomethylpyrimidine-forming)
R04448  ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase
R04509  ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase
R05636  1-Deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating)
R07459  ATP:[sulfur-carrier protein] adenylyltransferase
R07460  L-cysteine:[enzyme]-cysteine sulfurtransferase
R07461  [enzyme]-S-sulfanyl-L-cysteine:adenylyl-[sulfur-carrier protein] sulfurtransferase
R07463  glycine:oxygen oxidoreductase
R09977  2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate isomerase
R09993  4-amino-5-aminomethyl-2-methylpyrimidine aminohydrolase
R10246  L-tyrosine 4-methylphenol-lyase (2-iminoacetate-forming)
R10247  1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase
R10685  NAD+:glycine ADP-D-ribosyltransferase (dehydroalanine-producing)
R10686   
R10711   
R10712  2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate 2-methyl-4-aminopyrimidine-5-methenyltransferase
R11313  N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine amidohydrolase
R11314   
R11319  ADP:thiamin-diphosphate phosphotransferase
R12026  NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Compound
C00003  NAD+
C00018  Pyridoxal phosphate
C00022  Pyruvate
C00037  Glycine
C00068  Thiamin diphosphate
C00082  L-Tyrosine
C00097  L-Cysteine
C00118  D-Glyceraldehyde 3-phosphate
C00378  Thiamine
C01081  Thiamin monophosphate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C02892  Thiamine acetic acid
C03028  Thiamin triphosphate
C03373  Aminoimidazole ribotide
C04294  5-(2-Hydroxyethyl)-4-methylthiazole
C04327  4-Methyl-5-(2-phosphooxyethyl)thiazole
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C05856  Thiamine aldehyde
C11437  1-Deoxy-D-xylulose 5-phosphate
C15809  Iminoglycine
C15810  Sulfur-carrier protein
C15811  [Enzyme]-cysteine
C15812  [Enzyme]-S-sulfanylcysteine
C15813  Adenylyl-[sulfur-carrier protein]
C15814  Thiocarboxy-[sulfur-carrier protein]
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20246  2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C20267  4-Amino-5-aminomethyl-2-methylpyrimidine
C20784  ADP-5-ethyl-4-methylthiazole-2-carboxylate
Reference
  Authors
Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
  Title
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
  Journal
Curr Genet 47:156-62 (2005)
DOI:10.1007/s00294-004-0557-x
Reference
  Authors
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
  Title
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
  Journal
Biochemistry 42:12430-8 (2003)
DOI:10.1021/bi034902z
Reference
  Authors
Begley TP, Ealick SE, McLafferty FW
  Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
  Journal
Biochem Soc Trans 40:555-60 (2012)
DOI:10.1042/BST20120084
Reference
  Authors
Wightman R, Meacock PA
  Title
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
  Journal
Microbiology 149:1447-60 (2003)
DOI:10.1099/mic.0.26194-0
Reference
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
DOI:10.1038/nature10503
Reference
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
DOI:10.1146/annurev.biochem.78.072407.102340
Related
pathway
rn00010  Glycolysis / Gluconeogenesis
rn00230  Purine metabolism
rn00260  Glycine, serine and threonine metabolism
rn00270  Cysteine and methionine metabolism
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00750  Vitamin B6 metabolism
KO pathway
ko00730   

DBGET integrated database retrieval system