KEGG   PATHWAY: rn00740
Entry
rn00740                     Pathway                                

Name
Riboflavin metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
rn00740  Riboflavin metabolism
rn00740

Module
M00125  Riboflavin biosynthesis, GTP => riboflavin/FMN/FAD [PATH:rn00740]
Other DBs
GO: 0006771
Reaction
R00066  6,7-Dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase
R00160  FAD nucleotidohydrolase
R00161  ATP:FMN adenylyltransferase
R00425  GTP 7,8-8,9-dihydrolase (diphosphate-forming)
R00548  riboflavin-5-phosphate phosphohydrolase
R00549  ATP:riboflavin 5'-phosphotransferase
R00550  D-Glucose-1-phosphate:riboflavin 5'-phosphotransferase
R01732  Riboflavin hydrolase
R03458  5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase
R03459  2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase
R04457  5-amino-6-(D-ribitylamino)uracil butanedionetransferase
R04458   
R05705  FMNH2:NAD+ oxidoreductase
R05706  FMNH2:NADP+ oxidoreductase
R05707  reduced-riboflavin:NADP+ oxidoreductase
R07280  5-amino-6-(5-phospho-D-ribitylamino)uracil phosphohydrolase
R07281  D-ribulose 5-phosphate formate-lyase (L-3,4-dihydroxybutan-2-one 4-phosphate-forming)
R07306  GTP 8,9-hydrolase (phosphate-forming)
R08574  CTP:riboflavin 5'-phosphotransferase
R09083   
R09374  2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one amidohydrolase
R09375  2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one:NAD+ 1'-oxidoreductase
R09376  2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one:NADP+ 1'-oxidoreductase
R09377  2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one 2-aminohydrolase
R09520  FADH2:NADP+ oxidoreductase
R09748  FADH2:NAD+ oxidoreductase
R09750  reduced-riboflavin:NAD+ oxidoreductase
Compound
C00016  FAD
C00044  GTP
C00061  FMN
C00199  D-Ribulose 5-phosphate
C00255  Riboflavin
C00474  Ribitol
C01007  Reduced riboflavin
C01268  5-Amino-6-(5'-phosphoribosylamino)uracil
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C01352  FADH2
C01727  Lumichrome
C01847  Reduced FMN
C03114  Dimethylbenzimidazole
C04332  6,7-Dimethyl-8-(D-ribityl)lumazine
C04454  5-Amino-6-(5'-phospho-D-ribitylamino)uracil
C04732  5-Amino-6-(1-D-ribitylamino)uracil
C05995  7-Hydroxy-6-methyl-8-ribityllumazine
C15556  L-3,4-Dihydroxybutan-2-one 4-phosphate
C15563  2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C18910  2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one
Reference
  Authors
Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS.
  Title
Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.
  Journal
Nucleic Acids Res 30:3141-51 (2002)
DOI:10.1093/nar/30.14.3141
Reference
  Authors
Fischer M, Haase I, Feicht R, Richter G, Gerhardt S, Changeux JP, Huber R, Bacher A.
  Title
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
  Journal
Eur J Biochem 269:519-26 (2002)
DOI:10.1046/j.0014-2956.2001.02674.x
Reference
  Authors
Haase I, Fischer M, Bacher A, Schramek N.
  Title
Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
  Journal
J Biol Chem 278:37909-15 (2003)
DOI:10.1074/jbc.M303090200
Reference
  Authors
Fischer M, Romisch W, Illarionov B, Eisenreich W, Bacher A.
  Title
Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.
  Journal
Biochem Soc Trans 33:780-4 (2005)
DOI:10.1042/BST0330780
Related
pathway
rn00030  Pentose phosphate pathway
rn00040  Pentose and glucuronate interconversions
rn00230  Purine metabolism
rn00860  Porphyrin and chlorophyll metabolism
KO pathway
ko00740   

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