KEGG   REACTION: R00014Help
Entry
R00014                      Reaction                               

Name
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Definition
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
Equation
Comment
2-oxoglutarate dehydrogenase complex: pyruvate dehydrogenase (see R01699), subsequently R03270
TPP-dependent enzymatic reaction (see R00006), subsequently R03050
TPP-dependent enzymatic reaction (see R00226), subsequently R04672
TPP-dependent enzymatic reaction (see R00224), subsequently R00755
TPP-dependent enzymatic reaction (see R08648), subsequently R04673
Reaction class
RC00027  C00068_C05125
RC02744  C00022_C05125
Enzyme
1.2.4.1         2.2.1.6         4.1.1.1
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00620  Pyruvate metabolism
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01130  Biosynthesis of antibiotics
Orthology
K00161  pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K01568  pyruvate decarboxylase [EC:4.1.1.1]
K01652  acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
K01653  acetolactate synthase I/III small subunit [EC:2.2.1.6]
K11258  acetolactate synthase II small subunit [EC:2.2.1.6]

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