KEGG   REACTION: R00209Help
Entry
R00209                      Reaction                               

Name
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating);
pyruvate dehydrogenase complex
Definition
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
Equation
Comment
multi-step reaction (see R01699+R02569+R07618)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00024
RC02742  C00022_C00024
Enzyme
1.2.4.1         1.8.1.4         2.3.1.12
Pathway
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01130  Biosynthesis of antibiotics
rn01200  Carbon metabolism
Module
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Orthology
K00161  pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
K00627  pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12]
Other DBs
RHEA: 28045

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