KEGG   REACTION: R00209Help
Entry
R00209                      Reaction                               

Name
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating);
pyruvate dehydrogenase complex
Definition
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
Equation
Comment
multi-step reaction (see R01699+R02569+R07618)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00024
RC02742  C00022_C00024
Enzyme
1.2.4.1         1.8.1.4         2.3.1.12
Pathway
rn01100  Metabolic pathways
rn01200  Carbon metabolism
Module
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Orthology
K00161  pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
K00627  pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12]
Other DBs
RHEA: 28045

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