KEGG   REACTION: R00209
Entry
R00209                      Reaction                               
Name
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating);
pyruvate dehydrogenase complex
Definition
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
Equation
C00022 + C00010 + C00003 <=> C00024 + C00011 + C00004 + C00080
Comment
multienzyme system: ec 1.2.4.1, ec 2.3.1.12 and ec 1.8.1.4
multi-step reaction (see R01699+R02569+R07618)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00024
RC02742  C00022_C00024
Enzyme
1.2.1.104
Pathway
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
Module
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.104
     R00209  Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
Orthology
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
K00627  pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]
Other DBs
RHEA: 28045

  All links  
Chemical reaction (1)   
   SABIO-RK (1)   
All databases (1)   

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