KEGG   REACTION: R00237
Entry
R00237                      Reaction                               
Name
(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
Definition
(3S)-Citramalyl-CoA <=> Acetyl-CoA + Pyruvate
Equation
C01011 <=> C00024 + C00022
Comment
the second step of two-step reaction (R03153+R00237, R00325, ec 4.1.3.22)
Reaction class
RC00502  C00024_C01011
RC01205  C00022_C01011
Enzyme
4.1.3.25
Pathway
rn00660  C5-Branched dibasic acid metabolism
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00376  3-Hydroxypropionate bi-cycle
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.25
     R00237  (3S)-Citramalyl-CoA <=> Acetyl-CoA + Pyruvate
Overall reaction [br08210.html]
 Carbon fixation
  R00237
Orthology
K08691  malyl-CoA/(S)-citramalyl-CoA lyase [EC:4.1.3.24 4.1.3.25]
K18292  (S)-citramalyl-CoA lyase [EC:4.1.3.25]
Reference
1  [PMID:24657929]
  Authors
Sasikaran J, Ziemski M, Zadora PK, Fleig A, Berg IA
  Title
Bacterial itaconate degradation promotes pathogenicity.
  Journal
Nat Chem Biol 10:371-7 (2014)
DOI:10.1038/nchembio.1482
Other DBs
RHEA: 22615

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