KEGG   REACTION: R00267
Entry
R00267                      Reaction                               
Name
isocitrate:NADP+ oxidoreductase (decarboxylating)
Definition
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
Equation
C00311 + C00006 <=> C00026 + C00011 + C00005 + C00080
Comment
two-step reaction (see R01899+R00268)
Reaction class
RC00001  C00005_C00006
RC00114  C00026_C00311
RC02801  C00011_C00311
Enzyme
1.1.1.42
Pathway
rn00480  Glutathione metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.42
     R00267  Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
Overall reaction [br08210.html]
 Carbon fixation
  R00267
Orthology
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Other DBs
RHEA: 19632

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (17)   
   KEGG PATHWAY (14)   
   KEGG MODULE (3)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG RCLASS (3)   
   SABIO-RK (1)   
Gene (10315)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (10314)   
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KEGG   REACTION: R01899
Entry
R01899                      Reaction                               
Name
isocitrate:NADP+ oxidoreductase
Definition
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
Equation
C00311 + C00006 <=> C05379 + C00005 + C00080
Comment
the first step of two-step reaction (see R00267, R01899+R00268)
subsequently R00268
Reaction class
RC00001  C00005_C00006
RC00084  C00311_C05379
Enzyme
1.1.1.42
Pathway
rn00020  Citrate cycle (TCA cycle)
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00740  Methylaspartate cycle
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.42
     R01899  Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
Orthology
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Other DBs
RHEA: 25591

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (13)   
   KEGG PATHWAY (10)   
   KEGG MODULE (3)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
   SABIO-RK (1)   
Gene (10315)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (10314)   
All databases (10338)   

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KEGG   REACTION: R00268
Entry
R00268                      Reaction                               
Name
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Definition
Oxalosuccinate <=> 2-Oxoglutarate + CO2
Equation
C05379 <=> C00026 + C00011
Comment
the second step of two-step reaction (see R00267, R01899+R00268)
following after R01899
Reaction class
RC00626  C00026_C05379
Enzyme
1.1.1.42
Pathway
rn00020  Citrate cycle (TCA cycle)
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00740  Methylaspartate cycle
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.42
     R00268  Oxalosuccinate <=> 2-Oxoglutarate + CO2
Orthology
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Other DBs
RHEA: 19384

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (13)   
   KEGG PATHWAY (10)   
   KEGG MODULE (3)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (10315)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (10314)   
All databases (10334)   

Download RDF
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