KEGG   REACTION: R00351
Entry
R00351                      Reaction                               
Name
acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
Definition
Citrate + CoA <=> Acetyl-CoA + H2O + Oxaloacetate
Equation
C00158 + C00010 <=> C00024 + C00001 + C00036
Comment
(pro-S)-carboxymethyl-forming (ec 2.3.3.1)
(pro-R)-carboxymethyl-forming (ec 2.3.3.3)
unknown stereospecificity (ec 2.3.3.16)
Reaction class
RC00004  C00010_C00024
RC00067  C00036_C00158
Enzyme
2.3.3.1         2.3.3.3         2.3.3.5         2.3.3.16
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00630  Glyoxylate and dicarboxylate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00012  Glyoxylate cycle
M00740  Methylaspartate cycle
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.1
     R00351  Citrate + CoA <=> Acetyl-CoA + H2O + Oxaloacetate
    2.3.3.3
     R00351  Citrate + CoA <=> Acetyl-CoA + H2O + Oxaloacetate
    2.3.3.5
     R00351  Citrate + CoA <=> Acetyl-CoA + H2O + Oxaloacetate
    2.3.3.16
     R00351  Citrate + CoA <=> Acetyl-CoA + H2O + Oxaloacetate
Orthology
K01647  citrate synthase [EC:2.3.3.1]
K01659  2-methylcitrate synthase [EC:2.3.3.5]
K05942  citrate (Re)-synthase [EC:2.3.3.3]
K27797  2-methylcitrate synthase [EC:2.3.3.5]
Other DBs
RHEA: 16848

  All links  
Chemical reaction (1)   
   SABIO-RK (1)   
All databases (1)   

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