KEGG   REACTION: R00621Help
Entry
R00621                      Reaction                               

Definition
2-Oxoglutarate + Thiamin diphosphate <=> 3-Carboxy-1-hydroxypropyl-ThPP + CO2
Equation
Comment
2-oxoglutarate dehydrogenase complex: oxoglutarate dehydrogenase (see R01700)
TPP-dependent enzymatic reaction (see R00621+R03316)
subsequently R03316
Reaction class
RC00027  C00068_C05381
RC02743  C00026_C05381
Enzyme
Pathway
rn00020  Citrate cycle (TCA cycle)
rn01120  Microbial metabolism in diverse environments
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Orthology
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]

KEGG   REACTION: R03316Help
Entry
R03316                      Reaction                               

Definition
3-Carboxy-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + Thiamin diphosphate
Equation
Comment
2-oxoglutarate dehydrogenase complex: oxoglutarate dehydrogenase (see R01700)
TPP-dependent enzymatic reaction (see R00621+R03316)
following after R00621
Reaction class
RC00027  C00068_C05381
RC00627  C15972_C16254
RC02883  C05381_C16254
Enzyme
Pathway
rn00020  Citrate cycle (TCA cycle)
rn01120  Microbial metabolism in diverse environments
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Orthology
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]

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