KEGG   REACTION: R00918Help
Entry
R00918                      Reaction                               

Name
propanoyl-CoA:(2S)-methylmalonyl-CoA malonyltransferase (cyclizing);
propanoyl-CoA:(2S)-methylmalonyl-CoA 2-C-acyltransferase (decarboxylating, oxoacyl-reducing and cyclizing)
Definition
Propanoyl-CoA + 6 (S)-Methylmalonyl-CoA + 6 NADPH + 6 H+ <=> 6-Deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
Equation
C00100 + 6 C00683 + 6 C00005 + 6 C00080 <=> C03240 + 7 C00010 + 6 C00011 + C00001 + 6 C00006
Comment
EryA MegA
multi-step reaction
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00100  C00010_C00683
RC02825  C00100_C03240
RC02826  C00683_C03240
RC02828  C00683_C03240
RC02829  C00683_C03240
RC02830  C00683_C03240
RC02831  C00683_C03240
Enzyme
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00774  Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B
Orthology
K10817  6-deoxyerythronolide-B synthase [EC:2.3.1.94]
Reference
1  [PMID:11752428]
  Authors
Tsai SC, Miercke LJ, Krucinski J, Gokhale R, Chen JC, Foster PG, Cane DE, Khosla C, Stroud RM
  Title
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.
  Journal
Proc Natl Acad Sci U S A 98:14808-13 (2001)
DOI:10.1073/pnas.011399198
Other DBs
RHEA: 23071

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