KEGG   REACTION: R00937Help
Entry
R00937                      Reaction                               

Name
5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Definition
Tetrahydrofolate + 2 NAD+ <=> Folate + 2 NADH + 2 H+
Equation
C00101 + 2 C00003 <=> C00504 + 2 C00004 + 2 C00080
Comment
two-step reaction (see R00936+R02235)
NADP+ (see R00940)
Reaction class
RC00001  C00003_C00004
RC00110  C00101_C00504
Enzyme
Pathway
rn00670  One carbon pool by folate
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
Orthology
K00287  dihydrofolate reductase [EC:1.5.1.3]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]

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