KEGG   REACTION: R01221
Entry
R01221                      Reaction                               
Name
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding);
glycine cleavage system
Definition
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
Equation
C00037 + C00101 + C00003 <=> C00143 + C00014 + C00011 + C00004 + C00080
Comment
multienzyme system
multi-step reaction (see R03425+R04125+R03815)
Reaction class
RC00001  C00003_C00004
RC00022  C00101_C00143
RC02834  C00014_C00037
Enzyme
1.4.1.27
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn00670  One carbon pool by folate
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01200  Carbon metabolism
Module
M00532  Photorespiration
M00621  Glycine cleavage system
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.27
     R01221  Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
Orthology
K00281  glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2]
K00282  glycine cleavage system P protein (glycine dehydrogenase) subunit 1 [EC:1.4.4.2]
K00283  glycine cleavage system P protein (glycine dehydrogenase) subunit 2 [EC:1.4.4.2]
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
K00605  glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10]
K02437  glycine cleavage system H protein
Other DBs
RHEA: 27761

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (12)   
   KEGG PATHWAY (10)   
   KEGG MODULE (2)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG RCLASS (3)   
   SABIO-RK (1)   
Gene (45496)   
   KEGG ORTHOLOGY (6)   
   KEGG GENES (45490)   
All databases (45522)   

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