KEGG   REACTION: R01325
Entry
R01325                      Reaction                               

Name
citrate hydro-lyase (cis-aconitate-forming)
Definition
Citrate <=> cis-Aconitate + H2O
Equation
Reaction class
RC00498  C00158_C00417
Enzyme
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00630  Glyoxylate and dicarboxylate metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00012  Glyoxylate cycle
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
M00740  Methylaspartate cycle
Orthology
K01681  aconitate hydratase [EC:4.2.1.3]
K01682  aconitate hydratase 2 / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]
Other DBs
RHEA: 10231

KEGG   REACTION: R01900
Entry
R01900                      Reaction                               

Name
isocitrate hydro-lyase (cis-aconitate-forming)
Definition
Isocitrate <=> cis-Aconitate + H2O
Equation
Reaction class
RC00618  C00311_C00417
Enzyme
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00630  Glyoxylate and dicarboxylate metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00012  Glyoxylate cycle
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
M00740  Methylaspartate cycle
Orthology
K01681  aconitate hydratase [EC:4.2.1.3]
K01682  aconitate hydratase 2 / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]
Other DBs
RHEA: 22147

KEGG   REACTION: R00709
Entry
R00709                      Reaction                               

Name
isocitrate:NAD+ oxidoreductase (decarboxylating)
Definition
Isocitrate + NAD+ <=> 2-Oxoglutarate + CO2 + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00114  C00026_C00311
RC02801  C00011_C00311
Enzyme
1.1.1.41        1.1.1.286
Pathway
rn00020  Citrate cycle (TCA cycle)
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
Orthology
K00030  isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]
K17753  isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Other DBs
RHEA: 23635

KEGG   REACTION: R01325
Entry
R01325                      Reaction                               

Name
citrate hydro-lyase (cis-aconitate-forming)
Definition
Citrate <=> cis-Aconitate + H2O
Equation
Reaction class
RC00498  C00158_C00417
Enzyme
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00630  Glyoxylate and dicarboxylate metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00012  Glyoxylate cycle
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
M00740  Methylaspartate cycle
Orthology
K01681  aconitate hydratase [EC:4.2.1.3]
K01682  aconitate hydratase 2 / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]
Other DBs
RHEA: 10231

KEGG   REACTION: R01900
Entry
R01900                      Reaction                               

Name
isocitrate hydro-lyase (cis-aconitate-forming)
Definition
Isocitrate <=> cis-Aconitate + H2O
Equation
Reaction class
RC00618  C00311_C00417
Enzyme
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00630  Glyoxylate and dicarboxylate metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00012  Glyoxylate cycle
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
M00740  Methylaspartate cycle
Orthology
K01681  aconitate hydratase [EC:4.2.1.3]
K01682  aconitate hydratase 2 / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]
Other DBs
RHEA: 22147

KEGG   REACTION: R01899
Entry
R01899                      Reaction                               

Name
Isocitrate:NADP+ oxidoreductase
Definition
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
Equation
Comment
the first step of two-step reaction (see R00267, R01899+R00268)
subsequently R00268
Reaction class
RC00001  C00005_C00006
RC00084  C00311_C05379
Enzyme
Pathway
rn00020  Citrate cycle (TCA cycle)
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00740  Methylaspartate cycle
Orthology
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Other DBs
RHEA: 25591

KEGG   REACTION: R00268
Entry
R00268                      Reaction                               

Name
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Definition
Oxalosuccinate <=> 2-Oxoglutarate + CO2
Equation
Comment
the second step of two-step reaction (see R00267, R01899+R00268)
following after R01899
Reaction class
RC00626  C00026_C05379
Enzyme
Pathway
rn00020  Citrate cycle (TCA cycle)
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00740  Methylaspartate cycle
Orthology
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Other DBs
RHEA: 19384

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