KEGG   REACTION: R01933
Entry
R01933                      Reaction                               

Name
2-oxoadipate dehydrogenase complex
Definition
2-Oxoadipate + CoA + NAD+ <=> Glutaryl-CoA + CO2 + NADH + H+
Equation
Comment
2-oxoglutarate dehydrogenase complex (see R08549)
multi-step reaction (see R01940+R02571+R07618)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00527
RC02833  C00322_C00527
Enzyme
1.2.4.2         1.8.1.4         2.3.1.61
Pathway
rn00310  Lysine degradation
rn00380  Tryptophan metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Orthology
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
K00658  2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
K15791  probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 [EC:1.2.4.2]
Other DBs
RHEA: 30798

KEGG   REACTION: R01940
Entry
R01940                      Reaction                               

Name
2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating)
Definition
2-Oxoadipate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine + CO2
Equation
Comment
2-oxoglutarate dehydrogenase complex:dihydrolipoyllysine-residue succinyltransferase
a part of multi-step reaction (see R01933, R01940+R02571+R07618)
subsequently R02571
Reaction class
RC00627  C06157_C15972
RC02833  C00322_C06157
Enzyme
Orthology
K15791  probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 [EC:1.2.4.2]
Other DBs
RHEA: 12191

KEGG   REACTION: R02571
Entry
R02571                      Reaction                               

Name
Glutaryl-CoA:dihydrolipoamide S-succinyltransferase
Definition
Glutaryl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
Equation
Comment
2-oxoglutarate dehydrogenase complex:dihydrolipoyllysine-residue succinyltransferase
a part of multi-step reaction (see R01933, R01940+R02571+R07618)
following after R01940
Reaction class
RC00004  C00010_C00527  C06157_C15973
RC02727  C00527_C06157
Enzyme
Orthology
K00658  2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]

KEGG   REACTION: R07618
Entry
R07618                      Reaction                               

Name
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Definition
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
Equation
Comment
Oxo-acid dehydrogenase complexes, dihydrolipoyl dehydrogenase
Reaction class
RC00001  C00003_C00004
RC00583  C15972_C15973
Enzyme
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Orthology
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
Other DBs
RHEA: 15048

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