KEGG   REACTION: R01978
Entry
R01978                      Reaction                               
Name
acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Definition
(S)-3-Hydroxy-3-methylglutaryl-CoA + CoA <=> Acetyl-CoA + H2O + Acetoacetyl-CoA
Equation
C00356 + C00010 <=> C00024 + C00001 + C00332
Comment
possibly two-step reaction (acetoacetyl-CoA-lyase, thioester-hydrolysing)
Reaction class
RC00004  C00010_C00024
RC00503  C00332_C00356
Enzyme
2.3.3.10
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn00650  Butanoate metabolism
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00088  Ketone body biosynthesis, acetyl-CoA => acetoacetate/3-hydroxybutyrate/acetone
M00095  C5 isoprenoid biosynthesis, mevalonate pathway
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.10
     R01978  (S)-3-Hydroxy-3-methylglutaryl-CoA + CoA <=> Acetyl-CoA + H2O + Acetoacetyl-CoA
Orthology
K01641  hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
Other DBs
RHEA: 10191

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (13)   
   KEGG PATHWAY (10)   
   KEGG MODULE (3)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
   SABIO-RK (1)   
Gene (3171)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (3170)   
All databases (3194)   

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