KEGG   REACTION: R02101
Entry
R02101                      Reaction                               
Name
5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
Definition
dUMP + 5,10-Methylenetetrahydrofolate <=> Dihydrofolate + dTMP
Equation
C00365 + C00143 <=> C00415 + C00364
Reaction class
RC00219  C00143_C00415
RC00332  C00364_C00365
Enzyme
2.1.1.45
Pathway
rn00240  Pyrimidine metabolism
rn00670  One carbon pool by folate
rn01100  Metabolic pathways
rn01232  Nucleotide metabolism
Module
M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45
     R02101  dUMP + 5,10-Methylenetetrahydrofolate <=> Dihydrofolate + dTMP
Orthology
K00560  thymidylate synthase [EC:2.1.1.45]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Other DBs
RHEA: 12107

  All links  
Chemical reaction (1)   
   SABIO-RK (1)   
All databases (1)   

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