KEGG   REACTION: R03202
Entry
R03202                      Reaction                               

Name
(S)-6-hydroxynicotine:oxygen oxidoreductase
Definition
(S)-6-Hydroxynicotine + H2O + Oxygen <=> 6-Hydroxypseudooxynicotine + Hydrogen peroxide
Equation
Comment
two-step reaction (see R11048+R11049)
Reaction class
RC00875  C01056_C01297
RC02755  C00007_C00027
Enzyme
Orthology
K19826  (S)-6-hydroxynicotine oxidase [EC:1.5.3.5]
Other DBs
RHEA: 11883

KEGG   REACTION: R11048
Entry
R11048                      Reaction                               

Definition
(S)-6-Hydroxynicotine + Oxygen <=> 5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + Hydrogen peroxide
Equation
Comment
first step of two-step reaction (see R03202, R11048+R11049)
Reaction class
RC02755  C00007_C00027
RC03336  C01056_C21075
Enzyme
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Module
M00810  Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde
Orthology
K19826  (S)-6-hydroxynicotine oxidase [EC:1.5.3.5]
Other DBs
RHEA: 46999

KEGG   REACTION: R11049
Entry
R11049                      Reaction                               

Definition
5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O <=> 6-Hydroxypseudooxynicotine
Equation
Comment
spontaneous
second step of two-step reaction (see R03202, R11048+R11049)
second step of two-step reaction (see R07170, R11050+R11049)
Reaction class
RC02086  C01297_C21075
Enzyme
1.5.3.5         1.5.3.6
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Module
M00810  Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde

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