KEGG   REACTION: R03444
Entry
R03444                      Reaction                               
Name
(R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase
Definition
(R)-2-Hydroxybutane-1,2,4-tricarboxylate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
Equation
C01251 <=> C04002 + C00001
Comment
first step of two-step reaction (see R09720, R03444+R04371)
Reaction class
RC00498  C01251_C04002
Enzyme
4.2.1.114       4.2.1.-
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.114
     R03444  (R)-2-Hydroxybutane-1,2,4-tricarboxylate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
    4.2.1.-
     R03444  (R)-2-Hydroxybutane-1,2,4-tricarboxylate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
Orthology
K16792  methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  methanogen homoaconitase small subunit [EC:4.2.1.114]
K17450  homoaconitase [EC:4.2.1.-]
Other DBs
RHEA: 26104

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (15)   
   KEGG PATHWAY (12)   
   KEGG MODULE (3)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
   SABIO-RK (1)   
Gene (532)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (529)   
All databases (554)   

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KEGG   REACTION: R04371
Entry
R04371                      Reaction                               
Name
homoisocitrate hydro-lyase
Definition
Homoisocitrate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
Equation
C05662 <=> C04002 + C00001
Comment
second step of two-step reaction (see R09720, R03444+R04371)
Reaction class
RC00618  C04002_C05662
Enzyme
4.2.1.36        4.2.1.114
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.36
     R04371  Homoisocitrate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
    4.2.1.114
     R04371  Homoisocitrate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
Orthology
K01705  homoaconitate hydratase [EC:4.2.1.36]
K16792  methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  methanogen homoaconitase small subunit [EC:4.2.1.114]
Other DBs
RHEA: 15488

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (15)   
   KEGG PATHWAY (12)   
   KEGG MODULE (3)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG RCLASS (1)   
   SABIO-RK (1)   
Gene (558)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (555)   
All databases (581)   

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