KEGG   REACTION: R03953
Entry
R03953                      Reaction                               
Definition
3-Iodo-L-tyrosine + 3,5-Diiodo-L-tyrosine + Hydrogen peroxide <=> Triiodothyronine + Dehydroalanine + 2 H2O
Equation
C02515 + C01060 + C00027 <=> C02465 + C02218 + 2 C00001
Comment
thyroid peroxidase, TPO
reaction on thyroglobulin [KO:K10809] (see R08522)
Reaction class
RC00878  C01060_C02465
RC01037  C02218_C02515
Enzyme
1.11.1.8
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
Module
M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.8
     R03953  3-Iodo-L-tyrosine + 3,5-Diiodo-L-tyrosine + Hydrogen peroxide <=> Triiodothyronine + Dehydroalanine + 2 H2O
Orthology
K00431  thyroid peroxidase [EC:1.11.1.8]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (541)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (540)   
All databases (556)   

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