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| Name |
6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase
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| Definition |
6-Lactoyl-5,6,7,8-tetrahydropterin + NADP+ <=> 6-Pyruvoyltetrahydropterin + NADPH + H+
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| Brite |
Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.21
R04285 6-Lactoyl-5,6,7,8-tetrahydropterin + NADP+ <=> 6-Pyruvoyltetrahydropterin + NADPH + H+
1.1.1.184
R04285 6-Lactoyl-5,6,7,8-tetrahydropterin + NADP+ <=> 6-Pyruvoyltetrahydropterin + NADPH + H+
1.1.1.220
R04285 6-Lactoyl-5,6,7,8-tetrahydropterin + NADP+ <=> 6-Pyruvoyltetrahydropterin + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
1. Oxidoreductase reactions
1.1.1.184
R03557 Secondary alcohol <=> Ketone
R04285 6-Lactoyl-5,6,7,8-tetrahydropterin <=> 6-Pyruvoyltetrahydropterin
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| Orthology |
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| Reference |
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| Authors |
Werner ER, Blau N, Thony B |
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| Title |
Tetrahydrobiopterin: biochemistry and pathophysiology. |
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Auerbach G, Herrmann A, Gutlich M, Fischer M, Jacob U, Bacher A, Huber R. |
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The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters. |
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| Reference |
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Takikawa S, Curtius HC, Redweik U, Leimbacher W, Ghisla S. |
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Biosynthesis of tetrahydrobiopterin. Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from human liver. |
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