KEGG   REACTION: R04558
Entry
R04558                      Reaction                               

Name
5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate-lyase (L-glutamine-hydrolysing; 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide-forming)
Definition
N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide + L-Glutamine <=> D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + L-Glutamate
Equation
Comment
two-step reaction (see R00256+R12152)
Reaction class
RC00010  C00025_C00064
RC01190  C04677_C04916
RC01943  C04666_C04916
Enzyme
Pathway
rn00340  Histidine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Module
M00026  Histidine biosynthesis, PRPP => histidine
Orthology
K01663  imidazole glycerol-phosphate synthase [EC:4.3.2.10]
K02500  imidazole glycerol-phosphate synthase subunit HisF [EC:4.3.2.10]
K02501  imidazole glycerol-phosphate synthase subunit HisH [EC:4.3.2.10]
Other DBs
RHEA: 24796

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